scholarly journals Costly Multidimensional Screening

2021 ◽  
Author(s):  
Frank Yang
Keyword(s):  
Multidimensional Screening

scholarly journals Reaction Discovery Using Microfluidic-Based Multidimensional Screening of Polycyclic Iminium Ethers

2010 ◽  
Vol 75 (6) ◽  
pp. 2028-2038 ◽  
Author(s):  
Jennifer L. Treece ◽  
John R. Goodell ◽  
David Vander Velde ◽  
John A. Porco ◽  
Jeffrey Aubé
Keyword(s):  
Reaction Discovery ◽  
Multidimensional Screening

scholarly journals Multidimensional Screening Platform for Simultaneously Targeting Oncogenic KRAS and Hypoxia-Inducible Factors Pathways in Colorectal Cancer

2016 ◽  
Vol 11 (5) ◽  
pp. 1322-1331 ◽  
Author(s):  
Michelle S. Bousquet ◽  
Jia Jia Ma ◽  
Ranjala Ratnayake ◽  
Pamela A. Havre ◽  
Jin Yao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hypoxia Inducible Factors ◽  
Multidimensional Screening ◽  
Screening Platform

The adolescent health review: a brief, multidimensional screening instrument

2001 ◽  
Vol 29 (2) ◽  
pp. 131-139 ◽  
Author(s):  
Patricia A Harrison ◽  
Timothy J Beebe ◽  
Eunkyung Park
Keyword(s):  
Adolescent Health ◽  
Screening Instrument ◽  
Multidimensional Screening ◽  
Health Review

Ironing, Sweeping, and Multidimensional Screening

Econometrica ◽  
1998 ◽  
Vol 66 (4) ◽  
pp. 783 ◽  
Author(s):  
Jean-Charles Rochet ◽  
Philippe Chone
Keyword(s):  
Multidimensional Screening

scholarly journals Discovery of EDA-Complex Photocatalyzed Reactions Using Multidimensional Image Processing: Iminophosphorane Synthesis as a Case Study

2021 ◽  
Author(s):  
Rodrigo Silva ◽  
Gabriel Batista ◽  
Timothy Brocksom ◽  
Kleber de Oliveira
Keyword(s):  
Image Processing ◽  
Digital Image Processing ◽  
Digital Image ◽  
Color Change ◽  
Visible Spectrum ◽  
Screening Strategy ◽  
Multidimensional Screening ◽  
Eda Complex ◽  
Tlc Analysis

Abstract Herein, we report a multidimensional screening strategy for the discovery of EDA-complex photocatalyzed reactions using only photographic devices (webcam, cellphone) and TLC analysis. An algorithm was designed to identify automatically EDA-complex reactive mixtures in solution from digital image processing in a 96-wells microplate and by TLC-analysis. The code highlights the region of absorption of the mixture in the visible spectrum, and the quantity of the color change through grayscale values. Furthermore, the code identifies automatically the blurs on the TLC plate and classifies the mixture as colorimetric reactions, non-reactive or potentially reactive EDA mixtures. This strategy allowed us to discover and then optimize a new EDA-mediated approach for obtaining iminophosphoranes in up to 90% yield.

scholarly journals Diseño y análisis psicométrico de una escala para evaluar riesgo suicida en adolescentes argentinos

2021 ◽  
Vol 26 (3) ◽  
pp. 203-216
Author(s):  
Aixa Lidia Galarza ◽  
Mercedes Fernández-Liporace ◽  
Claudia Castañeiras ◽  
Agustín Freiberg-Hoffmann
Keyword(s):  
Suicide Risk ◽  
Discriminant Validity ◽  
Face Validity ◽  
Public Health Issue ◽  
Psychometric Analysis ◽  
Convergent And Discriminant Validity ◽  
Specific Dimension ◽  
Apoyo Social ◽  
Factores De Riesgo ◽  
Multidimensional Screening

Design and psychometric analysis of a suicide risk scale for Argentinean adolescents and young people Abstract: Suicidal behavior in adolescents and youth has become a public health issue which requires improving the available scales in order to enable the early detection of risk cases. Therefore, for this purpose, this study presents the design and psychometric analysis of the Argentinean Scale of Suicidality for Adolescents (EASA-I by its Spanish acronym) Screening. It measures a specific dimension of suicidal ideation and five risk factors: low self-esteem, negative perspective of the future, low emotion regulation, difficulties in problem-solving and lack of social support. This study was aimed at analyzing content construct and face validity, as well as convergent and discriminant validity evidence with external measures. Internal consistency of the scores was also examined. The sample was composed of 291 adolescents and young adults. Results suggest that the EASA-I constitutes a short and simple scale with adequate psychometric properties suitable to be used in different areas of application and research. Keywords: adolescents; youth; suicide risk; multidimensional assessment; screening. Resumen: Los comportamientos suicidas en la adolescencia y la juventud constituyen un problema de salud pública que exige mejorar las herramientas de evaluación disponibles, de cara a detectar precozmente casos en riesgo. Se presenta el diseño y análisis psicométrico de la Escala Argentina de Suicidalidad para Adolescentes EASA-I Screening. Su objetivo reside en la medición de una dimensión específica, i.e., la ideación suicida, más cinco factores de riesgo: baja autoestima, perspectiva negativa del futuro, baja regulación emocional, dificultades para la resolución de problemas y falta de apoyo social. Basándonos en una muestra de 291 adolescentes y jóvenes, se analizaron evidencias de validez de contenido, aparente y de constructo, así como de validez convergente y discriminante con medidas externas. Se examinó, además, la consistencia interna de las puntuaciones obtenidas. Los resultados indican que la EASA-I posee adecuadas propiedades técnicas para su uso en población local en diferentes ámbitos de aplicación e investigación. Palabras clave: adolescentes; jóvenes; riesgo suicida; evaluación multidimensional; screening.

scholarly journals Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Yuri Takada ◽  
Hiroaki Itoh ◽  
Atmika Paudel ◽  
Suresh Panthee ◽  
Hiroshi Hamamoto ◽  
...  
Keyword(s):  
Ion Channel ◽  
Large Scale ◽  
Antibacterial Activities ◽  
Gramicidin A ◽  
Ion Concentration ◽  
Peptide Antibiotic ◽  
Structure Activity ◽  
Common Ion ◽  
Multidimensional Screening ◽  
The Common

Abstract Gramicidin A (1) is a peptide antibiotic that disrupts the transmembrane ion concentration gradient by forming an ion channel in a lipid bilayer. Although long used clinically, it is limited to topical application because of its strong hemolytic activity and mammalian cytotoxicity, likely arising from the common ion transport mechanism. Here we report an integrated high-throughput strategy for discovering analogues of 1 with altered biological activity profiles. The 4096 analogue structures are designed to maintain the charge-neutral, hydrophobic, and channel forming properties of 1. Synthesis of the analogues, tandem mass spectrometry sequencing, and 3 microscale screenings enable us to identify 10 representative analogues. Re-synthesis and detailed functional evaluations find that all 10 analogues share a similar ion channel function, but have different cytotoxic, hemolytic, and antibacterial activities. Our large-scale structure-activity relationship studies reveal the feasibility of developing analogues of 1 that selectively induce toxicity toward target organisms.

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