Abnormal Bile Acid Metabolism is an Important Feature of Gut Microbiota and Fecal Metabolites in Patients with Slow Transit Constipation

2021 ◽  
Author(s):  
Yadong Fan ◽  
Chen Xu ◽  
Lulu Xie ◽  
Ying Wang ◽  
Shan Zhu ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Slow Transit Constipation ◽  
Slow Transit ◽  
Transit Constipation

Combined use of epigallocatechin-3-gallate (EGCG) and caffeine in low doses exhibits marked anti-obesity synergy through regulation of gut microbiota and bile acid metabolism

2021 ◽  
Author(s):  
Ming-zhi Zhu ◽  
Fang Zhou ◽  
Jian Ouyang ◽  
Qi-ye Wang ◽  
Yi-long Li ◽  
...  
Keyword(s):  
Bile Acid ◽  
Synergistic Effect ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Low Doses ◽  
Combined Use

Combined use of epigallocatechin-3-gallate (EGCG) and caffeine in low doses exhibits marked anti-obesity synergy. The synergistic effect may be attributed to regulation of gut microbiota and BA metabolism.

scholarly journals Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism

2019 ◽  
Vol 64 (1) ◽  
pp. 1900789 ◽  
Author(s):  
Yang Zhang ◽  
Gerd Bobe ◽  
Johana S. Revel ◽  
Richard R. Rodrigues ◽  
Thomas J. Sharpton ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Bile Acid ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism

Capsaicin improves glucose homeostasis by enhancing glucagon‐like peptide‐1 secretion through the regulation of bile acid metabolism via the remodeling of the gut microbiota in male mice

2020 ◽  
Vol 34 (6) ◽  
pp. 8558-8573 ◽  
Author(s):  
Suocheng Hui ◽  
Li Huang ◽  
Xiaolan Wang ◽  
Xiaohui Zhu ◽  
Min Zhou ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Glucose Homeostasis ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Male Mice ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Gut Microbiota Alterations from Three-Strain Yogurt Formulation Treatments in Slow-Transit Constipation

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Xiao-Ran Li ◽  
Chen-Jian Liu ◽  
Xiao-Dan Tang ◽  
He-Ming Zhang ◽  
Yi-Yong Luo ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gut Microbiota ◽  
Short Chain Fatty Acid ◽  
Intestinal Bacteria ◽  
Chain Fatty Acid ◽  
Slow Transit Constipation ◽  
Butanoic Acid ◽  
Treatment Groups ◽  
Slow Transit ◽  
Transit Constipation

The objective of this study was to evaluate the effects of a three-strain yogurt formulation in slow-transit constipation (STC) patients. Each individual in both treatment groups consumed 250 mL of the formulated yogurt daily for a week (7 days), and fecal samples were collected for gut microbiota and short-chain fatty acid (SCFA) analyses. A significant increase in the defection frequency (p<0.001) and bacterial diversity (p=0.027) at the 100% sequence homology level and a decrease in the concentrations of acetic acid (p=0.014), propionic acid (p=0.019), and butanoic acid (p=0.005) were observed after the STC patients consumed three-strain yogurt formulation. In addition, the consumption of the three-strain yogurt formulation significantly altered the composition of the intestinal bacteria in the STC patients. The relative abundances of 23 genera in the top dominating genera were altered significantly after the STC patients consumed the yogurt. In summary, the consumption of 250 mL day− the three-strain yogurt formulation described in this study can play a role in improving the symptoms of STC.

scholarly journals Functional microbiomics: Evaluation of gut microbiota-bile acid metabolism interactions in health and disease

Methods ◽  
2018 ◽  
Vol 149 ◽  
pp. 49-58 ◽  
Author(s):  
Benjamin H. Mullish ◽  
Alexandros Pechlivanis ◽  
Grace F. Barker ◽  
Mark R. Thursz ◽  
Julian R. Marchesi ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Health And Disease

Qiang-Gan formula extract improves non-alcoholic steatohepatitis via regulating bile acid metabolism and gut microbiota in mice

2020 ◽  
Vol 258 ◽  
pp. 112896
Author(s):  
Qiong Li ◽  
Meng Li ◽  
Fenghua Li ◽  
Wenjun Zhou ◽  
Yanqi Dang ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Alcoholic Steatohepatitis

scholarly journals Gut Microbiota Dysbiosis Associated with Bile Acid Metabolism in Neonatal Cholestasis Disease

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Meng Li ◽  
Sixiang Liu ◽  
Mingying Wang ◽  
Hongwei Hu ◽  
Jianwen Yin ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Neonatal Cholestasis ◽  
Gut Microbiota Dysbiosis

scholarly journals Clinical relevance of the relationship between changes in gut microbiota and bile acid metabolism in patients with intrahepatic cholangiocarcinoma

2020 ◽  
Vol 9 (2) ◽  
pp. 211-214
Author(s):  
Elisa Herraez ◽  
Marta R. Romero ◽  
Rocio I. R. Macias ◽  
Maria J. Monte ◽  
Jose J. G. Marin
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Intrahepatic Cholangiocarcinoma ◽  
Clinical Relevance ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
The Relationship

The influence of rosuvastatin on the gastrointestinal microbiota and host gene expression profiles

2017 ◽  
Vol 312 (5) ◽  
pp. G488-G497 ◽  
Author(s):  
J. A. Nolan ◽  
P. Skuse ◽  
K. Govindarajan ◽  
E. Patterson ◽  
N. Konstantinidou ◽  
...  
Keyword(s):  
Gene Expression ◽  
Community Structure ◽  
Bile Acid ◽  
Microbial Community ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Bile Acid Metabolism ◽  
Gastrointestinal Microbiota

Statins are the most widely prescribed medications worldwide for the treatment of hypercholesterolemia. They inhibit the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-R), an enzyme involved in cholesterol synthesis in higher organisms and in isoprenoid biosynthesis in some bacteria. We hypothesized that statins may influence the microbial community in the gut through either direct inhibition or indirect mechanisms involving alterations to host responses. We therefore examined the impact of rosuvastatin (RSV) on the community structure of the murine gastrointestinal microbiota. RSV was orally administered to mice and the effects on the gut microbiota, host bile acid profiles, and markers of inflammation were analyzed. RSV significantly influenced the microbial community in both the cecum and feces, causing a significant decrease in α-diversity in the cecum and resulting in a reduction of several physiologically relevant bacterial groups. RSV treatment of mice significantly affected bile acid metabolism and impacted expression of inflammatory markers known to influence microbial community structure (including RegIIIγ and Camp) in the gut. This study suggests that a commonly used statin (RSV) leads to an altered gut microbial composition in normal mice with attendant impacts on local gene expression profiles, a finding that should prompt further studies to investigate the implications of statins for gut microbiota stability and health in humans. NEW & NOTEWORTHY This work demonstrates that rosuvastatin administration in mice affects the gastrointestinal microbiota, influences bile acid metabolism, and alters transcription of genes encoding factors involved in gut homeostasis and immunity in the gastrointestinal tract.

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