scholarly journals Formulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride

2018 ◽  
Vol Volume 12 ◽  
pp. 349-364 ◽  
Author(s):  
Rouf Akram ◽  
Mahmood Ahmad ◽  
Asad Abrar ◽  
Rai Muhammad Sarfraz ◽  
Asif Mahmood
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Matrix Diffusion ◽  
Design And Development ◽  
Formulation Design ◽  
Diffusion Controlled

scholarly journals Paediatric Formulation: Design and Development

2020 ◽  
Vol 21 (19) ◽  
pp. 7118
Author(s):  
Antonio Lopalco ◽  
Nunzio Denora
Keyword(s):  
Drug Delivery ◽  
Patient Population ◽  
State Of The Art ◽  
Original Research ◽  
Special Issue ◽  
Formulation Development ◽  
Design And Development ◽  
Formulation Design ◽  
Age Appropriate ◽  
Paediatric Formulation

The development of medicines designed for children can be challenging since this distinct patient population requires specific needs. A formulation designed for paediatric patients must consider the following aspects: patient population variability; dose flexibility; route of administration; patient compliance; drug and excipient tolerability. The purpose of this Special Issue entitled “Paediatric Formulation: Design and Development” is to provide an update on both state-of-the-art methodology and operational challenges in the design and development of paediatric formulations. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients. This editorial, briefly, summarizes the objects of nine original research and review papers published in this Special Issue.

Optimization and Formulation Design of Gels of Diclofenac and Curcumin for Transdermal Drug Delivery by Box-Behnken Statistical Design

2011 ◽  
Vol 100 (2) ◽  
pp. 580-593 ◽  
Author(s):  
Hema Chaudhary ◽  
Kanchan Kohli ◽  
Saima Amin ◽  
Permender Rathee ◽  
Vikash Kumar
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Statistical Design ◽  
Formulation Design

scholarly journals In vitro Transdermal Delivery of Metformin from a HPMC/ PVA Based TDS-patch at Different pH

2011 ◽  
Vol 3 (3) ◽  
pp. 651-657 ◽  
Author(s):  
L. Jahan ◽  
R. Ferdaus ◽  
S. M. Shaheen ◽  
M. Z. Sultan ◽  
M. A. Mazid
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Sustained Release ◽  
Release Rate ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Neutral Ph ◽  
Skin Ph ◽  
Diffusion Controlled

In order to evaluate the pHs effect on the transdermal drug delivery, HPMC/PVA based TDS-patch was prepared. In vitro transdermal dissolution was performed at 32 oC at different pHs.  Comparatively higher release rate was found in case of pH 7.4 than those of others. pHs 5.4 and 8 showed almost the same release pattern. The release fashion was Higuchi type of diffusion controlled release. This result showed that neutral pH would accumulate the maximum drug from such a TDS patch, where the skin pH (around 5.4)  does not support such a release. Sustained release of drug from such a patch prefers skin pH rather than neutral pH.Keywords: Transdermal drug delivery; Higuchi diffusion; Release rate; Metformin.© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi:10.3329/jsr.v3i3.7422               J. Sci. Res. 3 (3), 661-667 (2011)

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