Direct and Indirect Effect of Honey as a Functional Food Against Metabolic Syndrome and Its Skeletal Complications

Abstract Background Metabolic syndrome (MetS) is associated with an increased risk of morbidity and mortality in almost all chronic diseases. The most frequent methods for the calculation of a continuous MetS (cMetS) score have used the standardized residuals in linear regression (z-score). Recently, emerging data suggest that one of the main genetic targets is the CAV1, which plays a crucial role in regulating body fat distribution. This study is designed to investigate the relationship between CAV1 rs3807992 genotypes and cMetS, and to determine whether body fat distribution plays a mediating role in this regard. Methods The current cross-sectional study was conducted on 386 overweight and obese females. The CAV1 rs3807992 and body composition were measured by the PCR–RFLP method and bioelectrical impedance analysis, respectively. Serum profile of HDL-C, TGs, FPG, and Insulin were measured by standard protocols. Results GG allele carriers had significantly lowered Z-MAP (p = 0.02), total cMetS (p = 0.03) and higher Z-HDL (p = 0.001) compared with (A) allele carriers. There was a significant specific indirect effect (standardized coefficient = 0.19; 95% CI 0.01–0.4) of Visceral fat level (VFL). Although, total body fat was significantly associated with CAV1 rs3807992 and cMetS, the specific indirect effect was not significant (standardized coefficient = 0.21; 95% CI − 0.006, 0.44). VFL contributed to significant indirect effects of 35% on the relationship between CAV1 and cMetS. Conclusion Higher visceral adipose tissue may affect the relationship between CAV1 and cMetS. Although CAV1 rs3807992 is linked to VFL in our study, the influence of this polymorphism on MetS is not via total fat.

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Composition, polyphenol bioavailability, and health benefits of aronia berry: a review

Journal of Food Bioactives ◽

10.31665/10.31665/jfb.2020.11235 ◽

2020 ◽

Vol 11 ◽

Author(s):

Erica S. King ◽

Bradley W. Bolling

Keyword(s):

Metabolic Syndrome ◽

Molecular Weight ◽

Neurological Disease ◽

Functional Food ◽

Health Benefits ◽

Low Molecular Weight ◽

Aronia Melanocarpa ◽

Berry Composition ◽

Preclinical And Clinical Studies ◽

The Impact

Aronia berries (Aronia melanocarpa and Aronia mitschurinii) are underutilized functional food, rich in bioactives. Aronia berries have abundant levels of anthocyanins, proanthocyanidins, flavonols, and phenolic acids that may reduce the risk of non-communicable diseases such as diabetes, metabolic syndrome, and neurological disease. Aronia polyphenols are bioavailable, and the majority are transformed into low molecular-weight phenolics. The impact of biotransformation on aronia polyphenols health effects is not fully understood. The objective of this review is to analyze aronia berry composition, including polyphenols nutrients. Additionally, this review summarizes recent preclinical and clinical studies on the polyphenol bioavailability and health benefits upon aronia berry consumption to better understand its potential as a functional food.

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Mediation Role of Body Fat Distribution (FD) on the Relationship Between CAV-1 rs3807992 Polymorphism and Metabolic Syndrome in Overweight and Obese Women

10.21203/rs.3.rs-105868/v1 ◽

2020 ◽

Author(s):

Faezeh Abaj ◽

Said Abdul Ghafour Saeedy ◽

Khadijeh Mirzaei

Keyword(s):

Metabolic Syndrome ◽

Body Fat ◽

Indirect Effect ◽

Visceral Fat ◽

Bioelectrical Impedance ◽

Allele Carrier ◽

Obese Women ◽

Cross Sectional ◽

Increased Risk ◽

The Relationship

Abstract Background: Metabolic syndrome (MetS) carries increased risk of the mortality of almost all chronic diseases. The most frequently used methods for calculation of a continuous MetS (cMetS) score have used the MetS severity z- score. Caveolin-1 (CAV-1(is one of the gens that is suggested by some authors that has a great effect on the visceral fat. This study was designed to investigate the relationship between CAV-1 markers and cMetS, the associations between CAV-1 rs3807992 and FD; and to assess FD mediators of the predicted association between CAV-1 and cMetS. Methods: The current cross-sectional study was conducted on 404 overweight and obese females. The CAV-1 rs3807992 and anthropometric data were measured by the PCR-RFLP method and bioelectrical impedance analysis (BIA), respectively. Serum profiles (HDL-C, TG, FPG, and Insulin) were measured by standard protocols. Results: Individuals with GG allele had significantly lowered (Z-MAP (p=0.02), total cMetS (p=0.03)) and higher Z-HDL (p=0.001) compared with A allele carrier. There was a significant specific indirect effect (standardized coefficient = 0.19; 95% CI: 0.01–0.4) of VFL. Although, total body fat was significantly associated with CAV-1 rs3807992 and cMetS, the specific indirect effect was not significant (standardized coefficient = 0.21; 95% CI: (-0.006,0.44). Visceral fat level contributed to significant indirect effects of 35% on the relationship between CAV-1 and cMetS. Conclusion: Higher visceral adipose tissue may affect the relationship between CAV-1 and MetS. Although CAV-1 rs3807992 is linked to visceral fat in our study, the influence of this polymorphism on MetS is not via total fat.

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