scholarly journals A GSH-Responsive Nanoprodrug System Based on Self-Assembly of Lactose Modified Camptothecin for Targeted Drug Delivery and Combination Chemotherapy

2020 ◽  
Vol Volume 15 ◽  
pp. 10417-10424
Author(s):  
Chenxi Hou ◽  
Ning Ma ◽  
Ziyan Shen ◽  
Guanyu Chi ◽  
Shuang Chao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Combination Chemotherapy ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Targeted Drug

Anti-Glioma Effect with Targeting Therapy Using Folate Modified Nano-Micelles Delivery Curcumin

2020 ◽  
Vol 16 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Yihong He ◽  
Cong Wu ◽  
Jiayu Duan ◽  
Junming Miao ◽  
Hongyu Ren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Targeting Therapy ◽  
Tumor Bearing ◽  
Clinical Benefits ◽  
Targeted Drug ◽  
Novel Drug ◽  
Targeted Drug Delivery Systems

Targeted drug delivery systems have currently demonstrated considerable potential clinical benefits in cancer treatment. Curcumin has become a candidate anti-tumor drug for the therapy of glioblastoma multiforme (GBM) by increasing cell apoptosis and suppressing cell proliferation. In current research, we explored a novel targeted drug delivery system with a self-assembly measure by curcumin, MPEG-PLA and Fa-PEG-PLA. Compared with free curcumin and Cur/MPEG-PLA, Cur/Fa-PEG-PLA can remarkably suppress the growth of GL261 cells and promote apoptotic rate. Moreover, after the procession of tumor-bearing mice with curcumin/Fa-PEG-PLA complex, tumor growth in subcutaneous and intracranial tumor models were repressed via suppressing angiogenesis and facilitating apoptosis in vivo. The Curcumin/Fa-PEG-PLA nanoparticle may be a novel drug for the therapy of GBM.

scholarly journals H2S gasotransmitter-responsive polymer vesicles

2016 ◽  
Vol 7 (3) ◽  
pp. 2100-2105 ◽  
Author(s):  
Qiang Yan ◽  
Wei Sang
Keyword(s):  
Drug Delivery ◽  
Hydrogen Sulfide ◽  
Cell Signaling ◽  
Diblock Copolymer ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Signaling Molecule ◽  
Polymer Vesicles ◽  
Responsive Polymer ◽  
Targeted Drug

A type of new polymeric vesicle self-assembly byo-azidomethylbenzoate-containing diblock copolymer can respond to the cell signaling molecule hydrogen sulfide (H2S). The intracellular H2S gasotransmitter can trigger biomimetic polymersome disruption for targeted drug delivery.

Self-Assembly of Morphology-Tunable Architectures from Tetraarylmethane Derivatives for Targeted Drug Delivery

Langmuir ◽  
2013 ◽  
Vol 29 (10) ◽  
pp. 3223-3233 ◽  
Author(s):  
Xinhua Huang ◽  
Young-Il Jeong ◽  
Byeong Kyu Moon ◽  
Lidong Zhang ◽  
Dae Hwan Kang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Targeted Drug

scholarly journals Pillar[5]arene-based amphiphilic supramolecular brush copolymers: fabrication, controllable self-assembly and application in self-imaging targeted drug delivery

2016 ◽  
Vol 7 (40) ◽  
pp. 6178-6188 ◽  
Author(s):  
Guocan Yu ◽  
Run Zhao ◽  
Dan Wu ◽  
Fuwu Zhang ◽  
Li Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Targeted Drug

Here we construct the first pillararene-based amphiphilic supramolecular brush copolymer, which can be utilized as a targeting self-imaging drug delivery vehicle.

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