scholarly journals Antiarthritic effect of aqueous and ethanolic leaf extracts of Pistia stratiotes in adjuvant-induced arthritis in Sprague-Dawley rats

2012 ◽  
pp. 41
Author(s):  
George Koffuor ◽  
Kyei ◽  
Boampong
Keyword(s):  
Pistia Stratiotes ◽  
Sprague Dawley ◽  
Leaf Extracts ◽  
Adjuvant Induced Arthritis ◽  
Sprague Dawley Rats

scholarly journals Therapeutic Effect of Saponin Rich Fraction ofAchyranthes asperaLinn. on Adjuvant-Induced Arthritis in Sprague-Dawley Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Pankaj S. Kothavade ◽  
Vipin D. Bulani ◽  
Dnyaneshwar M. Nagmoti ◽  
Padmini S. Deshpande ◽  
Nitin B. Gawali ◽  
...  
Keyword(s):  
Bone Destruction ◽  
Therapeutic Benefit ◽  
Stair Climbing ◽  
Sprague Dawley ◽  
Necrosis Factor Alpha ◽  
Achyranthes Aspera ◽  
Adjuvant Induced Arthritis ◽  
Sprague Dawley Rats ◽  
Antioxidant Parameters

Objective. Achyranthes asperaLinn. (AA) is used in folklore for the treatment of various inflammatory ailments and arthritis like conditions. Anti-inflammatory activity of saponin rich (SR) fraction of AA has been previously reported. The objective of this study was to assess the antiarthritic effect of SR fraction ofAchyranthes asperain adjuvant-induced arthritic rats.Methods.Arthritis was assessed by arthritis score, paw volume, changes in tibiotarsal joint thickness, hyperalgesic parameters, and spleen and thymus index. Haematological, serum, biochemical, and inflammatory cytokine andin vivoantioxidant parameters were measured on the last day of the study.Results.SR fraction significantly suppressed paw swelling and arthritic score and improved the pain threshold in motility and stair climbing tests. There was a reversal in the levels of altered parameters, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and antioxidant parameters like superoxide dismutase, catalase, glutathione, malondialdehyde, and nitric oxide. SR fraction significantly decreased plasma levels of tumor necrosis factor-alpha and interleukin-6. Moreover, histopathology revealed a significant reduction in synovial hyperplasia, inflammatory cell infiltration, and bone destruction in the joints.Conclusion.These observations explain the therapeutic benefit of SR fraction of AA in suppressing the progression of adjuvant-induced arthritis in rats.

scholarly journals Prophylactic or therapeutic administration of Holarrhena floribunda hydro ethanol extract suppresses Complete Freund’s Adjuvant-induced arthritis in Sprague-Dawley rats    

2020 ◽  
Author(s):  
Stephen Antwi ◽  
Daniel Oduro-Mensah ◽  
David Darko Obiri ◽  
Clara Lewis ◽  
Ebenezer Oduro-Mensah ◽  
...  
Keyword(s):  
Immune Response ◽  
Inflammatory Response ◽  
Ethanol Extract ◽  
Stem Bark ◽  
Sprague Dawley ◽  
Adjuvant Induced Arthritis ◽  
Sprague Dawley Rats ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant

Abstract Ethnopharmacological relevance In Ghanaian folk medicine, Holarrhena floribunda has anecdotal use for the treatment of inflammatory conditions. A hydro ethanol extract of the stem bark has previously been shown to be effective in the management of acute inflammation and anaphylaxis in rodents.Aim of the study This study was aimed at evaluating the usefulness of H. floribunda stem bark hydro ethanol extract (HFE) for the management of chronic inflammation in a murine model.Materials and Methods Anti-arthritic effect of the extract was evaluated using Complete Freund’s Adjuvant-induced arthritis in male Sprague-Dawley rats. Using both prophylactic and therapeutic treatment models, parameters assessed included oedema, serology of inflammatory response, radiology, bone tissue histology and haematology. Data were analysed by ANOVA followed by Tukey’s multiple comparisons post hoc test.Results HFE at 50–500 mg/kg dose-dependently [P ≥ 0.0354 (prophylactic) and P ≥ 0.0001 (therapeutic)] inhibited swelling of the injected paw upon prophylactic [≤ 81.26 % (P < 0.0001)] or therapeutic [≤ 67.92 % (P < 0.01)] administration — and prevented spread of arthritis to the contralateral paw. Inflammation alleviation activity of HFE was further demonstrated by decrease in arthritis score, radiologic score and erythrocyte sedimentation rate. HFE at all doses significantly reduced serum IL-1α (P < 0.0197), and 500 mg/kg HFE reduced serum IL-6 (P = 0.0032). In contrast, serum concentrations of IL-10, protein kinase A and cyclic adenosine monophosphate were enhanced (P ≤ 0.0436). HFE consistently showed better prophylactic activity than when administered therapeutically.Conclusions The data demonstrate that HFE suppresses CFA-induced arthritis and modulates regulators of inflammation; including IL-1α, -6 and -10 which also play mediatory roles in several immune response pathways. These make HFE a strong candidate for development as an agent for management and modulation of inflammation and the inflammatory response, including immune response-related adverse events such as seen in severe COVID-19.

Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne

2019 ◽  
Vol 235 ◽  
pp. 460-471 ◽  
Author(s):  
Umme Habiba Hassan ◽  
Alamgeer ◽  
Muhammad Shahzad ◽  
Arham Shabbir ◽  
Shah Jahan ◽  
...  
Keyword(s):  
Inflammatory Mediators ◽  
Sprague Dawley ◽  
Adjuvant Induced Arthritis ◽  
Sprague Dawley Rats

scholarly journals Fertility enhancing effects of methanolic leaf extract of Dracaena arborea in albino rats (Rattus norvegicus)

2013 ◽  
Vol 58 (No. 11) ◽  
pp. 520-524 ◽  
Author(s):  
S.O. Ekere ◽  
C.N. Okoye ◽  
A.F. Udoumoh
Keyword(s):  
Leaf Extract ◽  
Albino Rats ◽  
Epididymal Sperm ◽  
Sprague Dawley ◽  
Leaf Extracts ◽  
Sprague Dawley Rats ◽  
Testicular Weight ◽  
Testicular Morphology ◽  
Group A ◽  
Testicular Histology

The effects of methanolic extract of Dracaena arborea on mean testicular weight, mean cauda epididymal sperm reserve, and testicular morphology were evaluated. A total of sixty mature male Sprague Dawley rats were divided into three equal groups. The first group (A) received distilled water while the other two groups (B and C) received orally the methanolic leaf extracts of Dracaena arborea in two doses (100&nbsp;and 500 mg/kg, respectively) daily for 84 days. Following oral administration of the extract, mean testicular weight, mean cauda epididymal sperm reserve, and testicular morphology were determined on days 28, 42, 56, 70, and 84. The extract produced a significant and dose-dependent increase (P &lt; 0.05) in the sperm number. There was also a significant increase (P &lt; 0.05) in the mean testicular weights on days 70 and 84 of the extract administration. The testicular morphology remained unchanged while further testicular histology examination revealed increased spermatogenesis. It was concluded that the methanolic leaf extract of D. arborea has fertility enhancing properties. &nbsp;

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