<p>Value of Platelet Distribution Width and Mean Platelet Volume in Disease Activity Score of Rheumatoid Arthritis</p>

Abstract Objective To assess the utility of Patient Based Disease Activity Score 2 (PDAS 2) in assessing the disease activity in Rheumatoid arthritis (RA). Methods A prospective cohort study was conducted on 80 patients of RA. The demographic and clinical characteristics of the patients were recorded. They were assessed for disease activity using “Disease Activity Score 28” (DAS 28), “Clinical Disease Activity Index” (CDAI) and PDAS 2 score at baseline (M0), at 2 months (M2) and at 4 months(M4) while they were on treatment. Data was analyzed for correlation of PDAS-2 with other scores and internal reliability. P < 0.05 was considered for statistical significance. Results The mean age was 40.13\(\pm\) 11.74 years with 70 females and 10 males. There was significant reduction in DAS28, CDAI and PDAS 2 score over 4 month follow up (all scores’ p values < 0.001). Internal reliability (as assessed by Cronbach’s Alpha) of PDAS 2 was 0.578. PDAS 2 showed significant correlation with DAS28 at M0, M2 and M4 (r = 0.792, 0.757 and 0.669 respectively, p value < 0.001) and CDAI (r = 0.861, 0.832 and 0.695 respectively, p value < 0.001). Overall there was a significant agreement between DAS 28 and PDAS 2 (K = 0.788,p < 0.001) and between CDAI and PDAS 2 (K = 0.766,p < 0.001). Conclusion PDAS-2 score can be routinely used in the clinical practice owing to its correlation with DAS-28/CDAI and because of the advantage that it assessed the patients’ daily living activities.

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EFFICACY OF METHOTREXATE VERSUS LEFLUNOMIDE VERSUS COMBINATION OF BOTH IN ACTIVE RHEUMATOID ARTHRITIS

Pakistan Armed Forces Medical Journal ◽

10.51253/pafmj.v6i6.4646 ◽

2021 ◽

Vol 71 (6) ◽

pp. 1916-19

Author(s):

Syed Haider Tirmizi ◽

Amer Fakhr ◽

Ahsan Amer ◽

Kaswar Sajjad ◽

Khurram Haq Nawaz ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Disease Activity ◽

Active Rheumatoid Arthritis ◽

Disease Activity Score ◽

Remission Rate ◽

Activity Score ◽

Response To Treatment ◽

Military Hospital ◽

P Value ◽

Duration Of Symptoms

Objective: To determine the efficacy of Methotrexate versus Leflunomide versus combination of both among patients managed at Pak Emirates Military Hospital with active rheumatoid arthritis. Study Design: Prospective comparative study. Place and Duration of Study: Rheumatology/General Medicine Department, Pak Emirates Military Hospital Rawalpindi, from May 2019 to June 2020. Methodology: Patient of active rheumatoid arthritis who fulfilled American college of rheumatology criteria of 1997 were included in the study. They were randomly divided into three groups with group A receiving Methotrexate, group B receiving Leflunomide while group C received the combination of both Methotrexate and Leflunomide. Disease activity was assessed by using the Disease Activity Score-28 in all the three groups after three months of treatment. Results: Mean age of the study participants was 36.919 ± 6.85 years. One hundred and fifty (83.3%) patients were female while 30 (16.7%) were male. Out of 160 (88.9%) patients achieved remission according to Disease Activity Score-28 score at the end of three months while 20 (11.1%) did not achieve remission. Pearson chi-square test revealed that none of the factors studied including the treatment option had any statistically significant relationship with presence of remission among the target population (p-value 0.386, 0.815, 0.194 and 0.145 for age, gender, duration of symptoms and type of treatment respectively). Conclusion: Remission rate among the rheumatoid arthritis patients in response to treatment was overall good in the study. In terms of efficacy for symptoms of rheumatoid arthritis and achieving remission, after three months of treatment all the three options..................

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Methotrexate induced lung diseases in rheumatoid arthritis patients

QJM ◽

10.1093/qjmed/hcab116.007 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Mohamed Gamal Zaki ◽

Ahmad Mohamed El Yasaky ◽

Rana Ahmed El Hilaly ◽

Mayada Taha Mostafa

Keyword(s):

Rheumatoid Arthritis ◽

Disease Activity ◽

Lung Disease ◽

Disease Activity Score ◽

Pulmonary Function Tests ◽

Activity Score ◽

P Value ◽

Female Ratio ◽

Increased Risk ◽

Significant Difference

Abstract Background Rheumatoid arthritis (RA) is a progressive, systemic autoimmune disorder characterized by articular and extra-articular manifestations. The lung is commonly a site of extra-articular disease. The lung manifestations of RA vary and may include airways, parenchymal, vascular, and pleural disease. Manifestations of lung disease in RA typically follow the development of articular disease. Methotrexate (MTX)has shown efficacy for the treatment of several diseases, especially RA. Methotrexate has also been implicated as a causative agent in interstitial lung disease. Objective to find any association between MTX intake and lung abnormalities in RA patients. Patients and Methods This study included sixty adult RA patients, recruited from Ain Shams University Hospitals. Patients were divided into thirty patients on MTX therapy, and another thirty patients on non-methotrexate therapy. All underwent history, clinical examination, chest examination, evaluation of RA by modified disease activity score 28 (DAS 28) and pulmonary function tests(PFT). Results The age of patients receiving MTX ranged from 35-65 years and the non-MTX group was 35-57 years with a mean ±SD of 47.733±5.265 and 40.700 ±5.187, respectively. Male to female ratio of MTX group was about 1:3, while Non MTX group was about 1:9.There was no significant difference regarding age and sex. There was no difference between both group regarding modified DAS score and chest manifestations. There was no difference in PFT findings between patients on high or low dose of MTX therapy .Similarly, no association was found between disease activity score and PFT findings in both groups. On the other hand, a significant association between chest symptoms and PFT, P value<0.05 . Also a strong significant association was found between anticitrullinated protein antibodies (ACPA) status and PFT in both group, p value <0.05. Conclusion MTX treatment was not associated with an increased risk of RA-ILD diagnosis. On the contrary, evidence showed that MTX may delay the onset of ILD. There seems no reason to confuse the association of MTX and hypersensitivity pneumonitis with the onset of RAILD.ACPA antibody is considered a major risk factor in RA-ILD, ACPA titers constitute an independent factor associated not only with the presence but also with the severity of RA-ILD

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AB0344 Association between Red Blood Cells Distribution Width and Disease Activity Score in Rheumatoid Arthritis

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2014-eular.3729 ◽

2014 ◽

Vol 73 (Suppl 2) ◽

pp. 918.2-918 ◽

Cited By ~ 1

Author(s):

M. Calabria ◽

C. Bruno ◽

C. Tripolino ◽

F. Ursini ◽

S. Naty ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Disease Activity ◽

Red Blood Cells ◽

Blood Cells ◽

Disease Activity Score ◽

Activity Score ◽

Distribution Width

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Can mean platelet volume and red blood cell distribution width show disease activity in rheumatoid arthritis?

Biomarkers in Medicine ◽

10.2217/bmm-2016-0148 ◽

2016 ◽

Vol 10 (9) ◽

pp. 967-974 ◽

Cited By ~ 26

Author(s):

Duygu Tecer ◽

Melek Sezgin ◽

Arzu Kanık ◽

Nurgül Arıncı İncel ◽

Özlem Bölgen Çimen ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Blood Cell ◽

Disease Activity ◽

Red Blood Cell ◽

Mean Platelet Volume ◽

Cell Distribution ◽

Platelet Volume ◽

Distribution Width ◽

Red Blood Cell Distribution

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Platelet Distribution Width and Mean Platelet Volume Are Not Correlated with the Disease Activity Indices of Ankylosing Spondylitis

Journal of Rheumatic Diseases ◽

10.4078/jrd.2017.24.3.143 ◽

2017 ◽

Vol 24 (3) ◽

pp. 143

Author(s):

Sejin Byun ◽

Seung Min Jung ◽

Jason Jungsik Song ◽

Yong-Beom Park ◽

Sang-Won Lee

Keyword(s):

Ankylosing Spondylitis ◽

Disease Activity ◽

Mean Platelet Volume ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Activity Indices

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Platelet indices evaluation in patients with dengue fever

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20182287 ◽

2018 ◽

Vol 6 (6) ◽

pp. 2054 ◽

Cited By ~ 4

Author(s):

Payal Mukker ◽

Smitha Kiran

Keyword(s):

Platelet Count ◽

Dengue Fever ◽

Mean Platelet Volume ◽

Dengue Infection ◽

P Value ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Platelet Indices ◽

Significant Difference

Background: Platelet indices (PIs)-Platecrit, mean platelet volume (MPV) and platelet distribution width (PDW)-are a group of platelet parameters obtained as a part of complete blood count using automated hematology analyzers. Evidence suggests that PIs may have diagnostic and prognostic value in febrile thrombocytopenia. This study aims to understand the profile of PIs in dengue fever. Aims and objectives was to study the platelet indices in patients with dengue fever.Methods: The present study is a retrospective observational study conducted in a tertiary hospital in Kerala. Platelet count, mean platelet volume (MPV), platecrit and Platelet distribution width (PDW) along with routine blood parameters hemoglobin(Hb), hematocrit, WBC, Platelet count, serum bilirubin, liver enzymes (AST, ALT) of 123 patients were collected. These 123 patients were grouped into three according to the platelet count (<20000,20000-100000, >100000). All the test results are available in hospital database. This was accessed using inpatient numbers obtained from medical records department of our institution. All analysis was done using free to use software R and values were rounded off to the nearest decimal point. Non normally distributed parameters were expressed as median (IQR). Parameters which did not follow normal distribution were analyzed with Kruskall Wallis test and the values are expressed as mean (SD) and a p value <0.05 was considered statistically significant.Results: Platelet indices PDW (57±13.8 vs. 55.4±6.9, p value 0.001) and MPV (9.2±0.09 vs. 13.8±1.3fL, p value <0.001) values were significantly altered in dengue fever with platelet counts below 20,000 compared to platelet count more than one lakh group. Similarly, the Platelet index (MPVxPDW\PLCxPCT), MPV\PLC, MPV\Platecrit, PDW\PLC and PDW\Platecrit ratio showed statistically significant difference between the different platelet groups.Conclusions: Platelet indices are useful parameters in dengue infection. Other than platelet count, PDW, MPV, platecrit are useful to monitor dengue fever.

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