scholarly journals Hypermethylation of secreted frizzled-related proteins predicts poor prognosis in non-M3 acute myeloid leukemia

2017 ◽  
Vol Volume 10 ◽  
pp. 3635-3644 ◽  
Author(s):  
Hong Guo ◽  
Ting-juan Zhang ◽  
Xiang-mei Wen ◽  
Jing-dong Zhou ◽  
Ji-chun Ma ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Poor Prognosis ◽  
Related Proteins ◽  
Acute Myeloid

Hypoxia and expression of hypoxia-related proteins in acute myeloid leukemia

2011 ◽  
Vol 35 (5) ◽  
pp. 573-574 ◽  
Author(s):  
Michael Fiegl ◽  
Karsten Spiekermann
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Related Proteins ◽  
Acute Myeloid

scholarly journals PF275 NAT10 UPREGULATION INDICATES A POOR PROGNOSIS IN ACUTE MYELOID LEUKEMIA

HemaSphere ◽  
2019 ◽  
Vol 3 (S1) ◽  
pp. 89
Author(s):  
P. Liang ◽  
R. Hu ◽  
Z. Liu ◽  
M. Miao ◽  
H. Jiang ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Poor Prognosis ◽  
Acute Myeloid

The miRNA-193B is a potent tumor-suppressor and a biomarker for poor prognosis in acute myeloid leukemia

2017 ◽  
Vol 53 ◽  
pp. S52
Author(s):  
Jan-Henning Klusmann ◽  
Razan Jammal ◽  
Kathrin Krowiorz ◽  
Nadine Haetscher ◽  
Raj Bhayadia ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Tumor Suppressor ◽  
Myeloid Leukemia ◽  
Poor Prognosis ◽  
Acute Myeloid ◽  
Potent Tumor

scholarly journals Upregulation of miR-99a is associated with poor prognosis of acute myeloid leukemia and promotes myeloid leukemia cell expansion

Oncotarget ◽  
2016 ◽  
Vol 7 (47) ◽  
pp. 78095-78109 ◽  
Author(s):  
Xiaohui Si ◽  
Xiaoyun Zhang ◽  
Xing Hao ◽  
Yunan Li ◽  
Zizhen Chen ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Cell Expansion ◽  
Myeloid Leukemia ◽  
Poor Prognosis ◽  
Leukemia Cell ◽  
Acute Myeloid ◽  
Myeloid Leukemia Cell

scholarly journals Elevated TNFRSF4 gene expression is a predictor of poor prognosis in non-M3 acute myeloid leukemia

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Siyu Gu ◽  
Jie Zi ◽  
Qi Han ◽  
Chunhua Song ◽  
Zheng Ge
Keyword(s):  
Gene Expression ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Poor Prognosis ◽  
Acute Myeloid

scholarly journals Upregulation of Glutamic-Oxaloacetic Transaminase 1 Predicts Poor Prognosis in Acute Myeloid Leukemia

2020 ◽  
Vol 10 ◽  
Author(s):  
Zhiheng Cheng ◽  
Yifeng Dai ◽  
Tiansheng Zeng ◽  
Yan Liu ◽  
Longzhen Cui ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Poor Prognosis ◽  
Glutamic Oxaloacetic Transaminase ◽  
Acute Myeloid

scholarly journals High CXCR2 expression predicts poor prognosis in adult patients with acute myeloid leukemia

2020 ◽  
Vol 11 ◽  
pp. 204062072095858
Author(s):  
Wei Tang ◽  
Zunyan Li ◽  
Xian Li ◽  
Zhonghua Huo
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Poor Prognosis ◽  
Mononuclear Cells ◽  
Cox Proportional Hazards ◽  
Adult Patients ◽  
The Cancer Genome Atlas ◽  
Clinical Parameters ◽  
Cxcr2 Expression ◽  
Acute Myeloid

Aims: This study aimed to assess the associations between clinical parameters, long-term outcomes, and expression of chemokine receptor CXCR2 in patients with acute myeloid leukemia (AML). Methods: From May 2013 to May 2017, 83 adult patients newly diagnosed with AML in the Affiliated Hospital of BeiHua University and Jilin Chemical Hospital, were enrolled in this study. The expression of CXCR2 in bone marrow mononuclear cells was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Clinical information and RNA-sequencing datasets of The Cancer Genome Atlas (TCGA) ( n = 136) were obtained. The associations between clinical parameters, prognosis, and CXCR2 expression were analyzed. Results: From both cohorts, patients with AML with M4 and M5 subtypes showed higher CXCR2 expression levels than those with other French-American-British (FAB) subtypes. Patients with extramedullary leukemia infiltration had higher CXCR2 levels than those without. In our cohort, patients with high CXCR2 levels (⩾2.099) had lower relapse-free survival (RFS) ( p < 0.000001) and overall survival (OS) ( p = 0.000107) than those with low levels (<2.099). High CXCR2 levels (⩾2.082) also indicated a poor OS in the TCGA cohort but only in patients younger than 65 years (5-year OS: 7.7% versus 29.9% in those with CXCR2 levels < 2.082). High CXCR2 levels independently predicted poor prognosis in AML patients, as determined by Cox proportional hazards models. Conclusion: Our results suggest that high CXCR2 expression associates with the monocytic lineage of AML and is an independent risk factor for poor patient prognosis.

Elevated frequencies of CD4+CD25+CD127lo regulatory T cells is associated to poor prognosis in patients with acute myeloid leukemia

2011 ◽  
Vol 129 (6) ◽  
pp. 1373-1381 ◽  
Author(s):  
Zhang Shenghui ◽  
Han Yixiang ◽  
Wu Jianbo ◽  
Yu Kang ◽  
Bi Laixi ◽  
...  
Keyword(s):  
T Cells ◽  
Acute Myeloid Leukemia ◽  
Regulatory T Cells ◽  
Myeloid Leukemia ◽  
Poor Prognosis ◽  
Acute Myeloid
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