Effect of temozolomide on survival in elderly patients with glioblastoma and impaired performance status: a propensity score-matching analysis [Corrigendum]

Abstract Background Few studies have focused on the role of hepatectomy for colorectal liver-limited metastases in elderly patients compared to matched younger patients. Methods From January 2000 to December 2018, 724 patients underwent hepatectomy for colorectal liver-limited metastases. Based on a 1:2 propensity score matching (PSM) model, 64 elderly patients (≥ 70 years of age) were matched to 128 younger patients (< 70 years of age) to obtain two balanced groups with regard to demographic, therapeutic, and prognostic factors. Results There were 73 elderly and 651 younger patients in the unmatched cohort. Compared with the younger group (YG), the elderly group (EG) had significantly higher proportion of American Society of Anesthesiologists score III and comorbidities and lower proportion of more than 3 liver metastases and postoperative chemotherapy (p < 0.05). After PSM for these factors, rat sarcoma virus proto-oncogene/B-Raf proto-oncogene (RAS/BRAF) mutation status and primary tumor sidedness, the EG had significantly less median intraoperative blood loss than the YG (175 ml vs. 200 ml, p = 0.046), a shorter median postoperative hospital stay (8 days vs. 11 days, p = 0.020), and a higher readmission rate (4.7% vs.0%, p = 0.036). The EG also had longer disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS) compared to the YG, but these findings were not statistically significant (p > 0.05). Old age was not an independent factor for DFS, OS, and CSS by Cox multivariate regression analysis (p > 0.05). Conclusions Hepatectomy is safe for colorectal liver-limited metastases in elderly patients, and these patients may subsequently benefit from prolonged DFS, OS, and CSS.

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Short-term outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma in elderly patients: A propensity score matching analysis

10.21203/rs.3.rs-118776/v1 ◽

2020 ◽

Author(s):

Kazuteru Monden ◽

Hiroshi Sadamori ◽

Masayoshi Hioki ◽

Satoshi Ohno ◽

Norihisa Takakura

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Resection ◽

Propensity Score ◽

Elderly Patients ◽

Propensity Score Matching ◽

Oral Intake ◽

Short Term ◽

Open Liver Resection ◽

Propensity Score Matching Analysis ◽

Baseline Characteristics

Abstract The number of elderly patients with hepatocellular carcinoma (HCC) requiring surgical treatment has been continuously increasing. This study aimed to examine the safety and feasibility of laparoscopic liver resection (LLR) versus open liver resection (OLR) for HCC in elderly patients at our institution in Japan.Between 2010 and 2018, LLR and OLR were performed in 80 and 138 elderly patients (>70 years) who were diagnosed with HCC, respectively. Propensity score matching (PSM) analysis with covariates of baseline characteristics was applied. Intra- and postoperative data were evaluated in both groups.After PSM, 56 patients who underwent LLR and OLR, respectively, were compared. No significant differences in demographic, clinical data, and operative times were observed. Blood loss (OLR: 327 mL; LLR: 50 mL; P< 0.001), length of postoperative hospital stay (OLR: 12 days; LLR: 7 days; P< 0.001), and time to start oral intake (OLR: 2 days; LLR: 1 day; P< 0.001) were significantly lower and shorter in the LLR group than in the OLR group. The incidence of complications over Clavien-Dindo class IIIa was similar between both groups.Our results suggest that advanced age alone is not a contraindication, and LLR can be a treatment option for elderly patients with HCC.

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Short-Term Outcomes of Laparoscopic Versus Open Liver Resection for Hepatocellular Carcinoma in Elderly Patients: A Propensity Score Matching Analysis

10.21203/rs.3.rs-118776/v2 ◽

2021 ◽

Author(s):

Kazuteru Monden ◽

Hiroshi Sadamori ◽

Masayoshi Hioki ◽

Satoshi Ohno ◽

Norihisa Takakura

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Resection ◽

Propensity Score ◽

Elderly Patients ◽

Propensity Score Matching ◽

Oral Intake ◽

Short Term ◽

Open Liver Resection ◽

Propensity Score Matching Analysis ◽

Baseline Characteristics

Abstract BackgroundThe number of elderly patients with hepatocellular carcinoma (HCC) requiring surgical treatment has been continuously increasing. This study aimed to examine the safety and feasibility of laparoscopic liver resection (LLR) versus open liver resection (OLR) for HCC in elderly patients at our institution in Japan.MethodsBetween 2010 and 2018, LLR and OLR were performed in 80 and 138 elderly patients (aged > 70 years) who were diagnosed with HCC, respectively. Propensity score matching (PSM) analysis with covariates of baseline characteristics was applied. Intra- and postoperative data were evaluated in both groups.ResultsAfter PSM, 56 patients who underwent LLR and OLR, respectively, were compared. No significant differences in demographic, clinical data, and operative times were observed. Blood loss (OLR: 327 mL, LLR: 50 mL [P < 0.001]), length of postoperative hospital stay (OLR: 12 days, LLR: 7 days [P < 0.001]), and time to start oral intake (OLR: 2 days, LLR: 1 day [P < 0.001]) were significantly lower and shorter in the LLR group than in the OLR group. The incidence of complications over Clavien-Dindo class IIIa was similar between both groups.ConclusionsOur results suggest that advanced age alone is not a contraindication, and LLR can be a treatment option for elderly patients with HCC.Trial registration: retrospectively registered

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Liver Resection for Colorectal Liver-limited Metastases in Elderly Patients: A Propensity Score Matching Analysis

10.21203/rs.3.rs-53989/v3 ◽

2020 ◽

Author(s):

Ke-Min Jin ◽

Kun Wang ◽

Quan Bao ◽

Hong-Wei Wang ◽

Bao-Cai Xing

Keyword(s):

Propensity Score ◽

Elderly Patients ◽

Propensity Score Matching ◽

Disease Free Survival ◽

The Elderly ◽

Multivariate Regression Analysis ◽

Cancer Specific Survival ◽

Younger Patients ◽

Propensity Score Matching Analysis ◽

American Society

Abstract Background: Few studies have focused on the role of hepatectomy for colorectal liver-limited metastases in elderly patients compared to matched younger patients.Methods: From January 2000 to December 2018, 724 patients underwent hepatectomy for colorectal liver-limited metastases. Based on a 1:2 propensity score matching (PSM) model, 64 elderly patients (≥70 years of age) were matched to 128 younger patients (＜70 years of age) to obtain two balanced groups with regards to demographic, therapeutic and prognostic factors.Results: There were 73 elderly and 651 younger patients in the unmatched cohort. Compared with the younger group (YG), the elderly group (EG) had significantly higher proportion of American Society of Anesthesiologists score Ⅲ and comorbidities, and lower proportion of more than 3 liver metastases and postoperative chemotherapy (p<0.05). After PSM for these factors, rat sarcoma virus proto-oncogene/B-Raf proto-oncogene (RAS/BRAF) mutation status and primary tumor sidedness, the EG had significantly less median intraoperative blood loss than the YG (175ml vs. 200ml, p=0.046), a shorter median postoperative hospital stay (8 days vs. 11 days, p=0.020) and a higher readmission rate (4.7% vs.0%, p=0.036). The EG also had longer disease-free survival (DFS), overall survival (OS) and cancer-specific survival (CSS) compared to the YG, but these findings were not statistically significant (p>0.05). Old age was not an independent factor for DFS, OS and CSS by Cox multivariate regression analysis (p>0.05).Conclusions: Hepatectomy is safe for colorectal liver-limited metastases in elderly patients, and these patients may subsequently benefit from prolonged DFS, OS and CSS.

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Are elderly patients at high risk for postoperative complications after robotic ventral hernia repair? A propensity score matching analysis

International Journal of Medical Robotics and Computer Assisted Surgery ◽

10.1002/rcs.2095 ◽

2020 ◽

Vol 16 (3) ◽

Author(s):

Omar Yusef Kudsi ◽

Fahri Gokcal ◽

Sara La Grange ◽

Naseem Bou‐Ayash ◽

Karen Chang

Keyword(s):

High Risk ◽

Postoperative Complications ◽

Propensity Score ◽

Elderly Patients ◽

Hernia Repair ◽

Propensity Score Matching ◽

Ventral Hernia ◽

Ventral Hernia Repair ◽

Propensity Score Matching Analysis ◽

Robotic Ventral Hernia Repair

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The Outcome of Complex Hepato-Pancreato-Biliary Surgery for Elderly Patients: A Propensity Score Matching Analysis

Digestive Surgery ◽

10.1159/000489826 ◽

2018 ◽

Vol 36 (4) ◽

pp. 323-330 ◽

Cited By ~ 2

Author(s):

Kosei Takagi ◽

Yuzo Umeda ◽

Ryuichi Yoshida ◽

Daisuke Nobuoka ◽

Takashi Kuise ◽

...

Keyword(s):

Risk Factors ◽

Propensity Score ◽

Elderly Patients ◽

Propensity Score Matching ◽

Postoperative Morbidity ◽

Postoperative Mortality ◽

Elderly Group ◽

Postoperative Outcomes ◽

Mortality And Morbidity ◽

Propensity Score Matching Analysis

Background/Aims: Postoperative mortality and morbidity rates after hepato-pancreato-biliary (HPB) surgery remain high, and the number of elderly patients requiring such surgery has been increasing. This study aimed to investigate postoperative outcomes of complex HPB surgery for elderly patients. Methods: We retrospectively reviewed perioperative data of 721 patients who underwent complex HPB surgery between 2010 and 2015. The patients were divided into 2 groups: elderly (≥75 years) and non-elderly (< 75 years). Surgical outcomes of both groups were compared after propensity score-matching analysis. Subsequently, risk factors for serious postoperative morbidity were identified by multivariate analysis. Results: Before matching, the elderly group (n = 170) had more comorbidities, such as cardiovascular and renal disease, than the non-elderly group (n = 551). Matching yielded elderly (n = 170) and non-elderly groups (n = 170) with similar preoperative backgrounds. The mortality and morbidity rates did not differ significantly between the groups. In multivariate analyses, operative time (OR 1.79; p = 0.005) and blood loss (OR 1.66; p = 0.03) were identified as independent risk factors for serious postoperative morbidity, whereas older age did not have a predictive impact (OR 1.16; p = 0.52). Conclusions: Although elderly patients had more comorbidities and higher incidences of postoperative mortality and several complications before matching, their postoperative outcomes were equivalent to those of non-elderly patients after matching.

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Benefits of laparoscopic surgery compared to open standard surgery for gastric carcinoma in elderly patients: propensity score-matching analysis

Surgical Endoscopy ◽

10.1007/s00464-018-6325-7 ◽

2018 ◽

Vol 33 (2) ◽

pp. 510-519 ◽

Cited By ~ 3

Author(s):

Manabu Yamamoto ◽

Mototsugu Shimokawa ◽

Hiroyuki Kawano ◽

Mitsuhiko Ohta ◽

Daisuke Yoshida ◽

...

Keyword(s):

Laparoscopic Surgery ◽

Propensity Score ◽

Gastric Carcinoma ◽

Elderly Patients ◽

Propensity Score Matching ◽

Propensity Score Matching Analysis ◽

Open Standard

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Propensity score-matching analysis comparing laparoscopic and open pancreaticoduodenectomy in elderly patients

Scientific Reports ◽

10.1038/s41598-019-49455-9 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 8

Author(s):

Heeji Shin ◽

Ki Byung Song ◽

Young Il Kim ◽

Young-Joo Lee ◽

Dae Wook Hwang ◽

...

Keyword(s):

Propensity Score ◽

Elderly Patients ◽

Propensity Score Matching ◽

Survival Rates ◽

Disease Free Survival ◽

Propensity Score Matching Analysis ◽

Oncological Outcomes ◽

Pancreatic Fistulas ◽

Clinically Significant ◽

Open Pancreaticoduodenectomy

Abstract There is little evidence on the safety and benefits of laparoscopic pancreaticoduodenectomy (LPD) in elderly patients; therefore, we evaluated the feasibility and efficacy of this procedure by comparing perioperative and oncological outcomes between LPD and open pancreaticoduodenectomy (OPD) in elderly patients. We retrospectively reviewed the data of 1,693 patients who underwent PD to manage periampullary tumours at a single institution between January 2014 and June 2017. Of these patients, 326 were elderly patients aged ≥70 years, with 56 patients allocated to the LPD group and 270 to the OPD group. One-to-one propensity score matching (56:56) was used to match the baseline characteristics of patients who underwent LPD and OPD. LPD was associated with significantly fewer clinically significant postoperative pancreatic fistulas (7.1% vs. 21.4%), fewer analgesic injections (10 vs. 15.6 times; p = 0.022), and longer operative time (321.8 vs. 268.5 minutes; p = 0.001) than OPD in elderly patients. There were no significant differences in 3-year overall and disease-free survival rates between the LPD and OPD groups. LPD had acceptable perioperative and oncological outcomes compared with OPD in elderly patients. LPD is a reliable treatment option for elderly patients with periampullary tumours.

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