scholarly journals PD-1 inhibitors dependent CD8+ T cells inhibit mouse colon cancer cell metastasis

2019 ◽  
Vol Volume 12 ◽  
pp. 6961-6971 ◽  
Author(s):  
Chang E Gao ◽  
Ming Zhang ◽  
Qian Song ◽  
Jian Dong
2019 ◽  
Author(s):  
Yuanchun Yue ◽  
Bao-Yu Yang ◽  
Jing Lu ◽  
Shu-Wen Zhang ◽  
Liu Liu ◽  
...  

Abstract The authors have requested that this preprint be removed from Research Square.


Oncology ◽  
2004 ◽  
Vol 67 (5-6) ◽  
pp. 441-449 ◽  
Author(s):  
Hiroyuki Kuwano ◽  
Tatsuya Miyazaki ◽  
Soichi Tsutsumi ◽  
Isao Hirayama ◽  
Tatsuo Shimura ◽  
...  

2010 ◽  
Vol 9 (1) ◽  
pp. 14-24 ◽  
Author(s):  
Nancy Gavert ◽  
Alessia Vivanti ◽  
John Hazin ◽  
Thomas Brabletz ◽  
Avri Ben-Ze'ev

2019 ◽  
Vol 34 (8) ◽  
pp. 1627-1635 ◽  
Author(s):  
Alireza Ghader ◽  
Arezoo Mohammadi Gazestani ◽  
Soraya Emamgholizadeh Minaei ◽  
Ali Abbasian Ardakani ◽  
Samideh Khoei ◽  
...  

2009 ◽  
Vol 125 (5) ◽  
pp. 996-1003 ◽  
Author(s):  
Antonietta Santoro ◽  
Simona Pisanti ◽  
Claudia Grimaldi ◽  
Angelo A. Izzo ◽  
Francesca Borrelli ◽  
...  

2013 ◽  
Vol 20 (6) ◽  
pp. 849-859 ◽  
Author(s):  
Hyun-Seuk Moon ◽  
Christos S Mantzoros

Both adiponectin (AD) and metformin (Met) have been proposed to downregulate cell proliferation of colon cancer cells, but whether their effect might be additive has not been studied to date. Genetic studies in humans have suggested an important role for interleukin 1β (IL1β) in cancer pathogenesis. Direct evidence that IL1β contributes to the development of colon cancer has not yet been fully confirmed and no previous studies have evaluated how IL1β may interact with AD and/or Met to regulate malignant potential and intracellular signaling pathways in human and mouse colon cancer cells. We conductedin vitrostudies using human (LoVo) and mouse (MCA38) colon cancer cell lines to evaluate whether AD and Met alone or in combination may antagonize IL1β-regulated malignant potential in human and mouse colon cancer cell lines. IL1β increased malignant potential and regulated the expression of tumor suppressor (p53) and cell cycle regulatory genes (p21, p27, and cyclin E2) in human and mouse colon cancer cell lines. These effects were reversed by co-administration of AD and/or Met and were additively altered by AD and Met in combination in a STAT3- and AMPK/LKB1-dependent manner. We also observed using fluorescence activated cell sorter analysis that IL1β-regulated cell cycle progression is altered by AD and Met alone or in combination. Our novel mechanistic studies provide evidence for an important role for IL1β in colon cancer and suggest that AD and/or Met might be useful agents in the management or chemoprevention of IL1β-induced colon carcinogenesis.


2001 ◽  
Vol 120 (5) ◽  
pp. A615-A615
Author(s):  
S KUWADA ◽  
C SCAIFE ◽  
J KUANG ◽  
R DAYNES

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