Disability Status, Unemployment, and Alcohol-Related Liver Disease (ALD) Mortality: A Large Sample Individual Level Longitudinal Study

BACKGROUND Evidence indicates that Internet addiction (IA) is associated with depression, but longitudinal studies have rarely been reported, and no studies have yet investigated potential common vulnerability or a possible specific causal relationship between these disorders. OBJECTIVE To overcome these gaps, the present 12-month longitudinal study based on a large-sample employed a cross-lagged panel model (CLPM) approach to investigate the potential common vulnerability and specific cross-causal relationships between IA and CSD (or depression). METHODS IA and clinically-significant depression (CSD) among 12 043 undergraduates were surveyed at baseline (as freshmen) and in follow-up after 12 months (as sophomores). Application of CLPM revealed two well-fitted design between IA and CSD, and between severities of IA and depression, adjusting for demographics. RESULTS Rates of baseline IA and CSD were 5.47% and 3.85%, respectively; increasing to 9.47% and 5.58%, respectively at follow-up. Among those with baseline IA and CSD, 44.61% and 34.48% remained stable at the time of the follow-up survey, respectively. Rates of new-incidences of IA and CSD over 12 months were 7.43% and 4.47%, respectively. Application of a cross-lagged panel model approach (CLPM, a discrete time structural equation model used primarily to assess causal relationships in real-world settings) revealed two well-fitted design between IA and CSD, and between severities of IA and depression, adjusting for demographics. Models revealed that baseline CSD (or depression severity) had a significant net-predictive effect on follow-up IA (or IA severity), and baseline IA (or IA severity) had a significant net-predictive effect on follow-up CSD (or depression severity). CONCLUSIONS These correlational patterns using a CLPM indicate that both common vulnerability and bidirectional specific cross-causal effects between them may contribute to the association between IA and depression. As the path coefficients of the net-cross-predictive effects were significantly smaller than those of baseline to follow-up cross-section associations, vulnerability may play a more significant role than bidirectional-causal effects. CLINICALTRIAL Ethics Committee of West China Hospital, Sichuan University (NO. 2016-171)

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Sa1511 FORECASTING HEPATITIS-RELATED LIVER DISEASE AMONG MIGRANTS TO SCANDINAVIA: ESTIMATING FUTURE DISEASE BURDENS IN FIVE NATIONS

Gastroenterology ◽

10.1016/s0016-5085(20)33956-1 ◽

2020 ◽

Vol 158 (6) ◽

pp. S-1316

Author(s):

Kenneth Valles ◽

Kritika Prasai ◽

Lewis R. Roberts

Keyword(s):

Liver Disease ◽

Related Liver Disease

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NAFLD and alcohol‐related liver disease will be responsible for almost all new diagnoses of cirrhosis in Canada by 2040

Hepatology ◽

10.1002/hep.32032 ◽

2021 ◽

Author(s):

Jennifer A. Flemming ◽

Maya Djerboua ◽

Patti A. Groome ◽

Christopher M. Booth ◽

Norah A. Terrault

Keyword(s):

Liver Disease ◽

Related Liver Disease ◽

Almost All

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Natural History of NAFLD

Journal of Clinical Medicine ◽

10.3390/jcm10061161 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1161

Author(s):

Raluca Pais ◽

Thomas Maurel

Keyword(s):

Liver Disease ◽

Natural History ◽

Disease Progression ◽

Specific Treatment ◽

Alcoholic Fatty Liver ◽

Individual Level ◽

Close Relationship ◽

History Of ◽

The Individual ◽

The Impact

The epidemiology and the current burden of chronic liver disease are changing globally, with non-alcoholic fatty liver disease (NAFLD) becoming the most frequent cause of liver disease in close relationship with the global epidemics of obesity, type 2 diabetes and metabolic syndrome. The clinical phenotypes of NAFLD are very heterogeneous in relationship with multiple pathways involved in the disease progression. In the absence of a specific treatment for non-alcoholic steatohepatitis (NASH), it is important to understand the natural history of the disease, to identify and to optimize the control of factors that are involved in disease progression. In this paper we propose a critical analysis of factors that are involved in the progression of the liver damage and the occurrence of extra-hepatic complications (cardiovascular diseases, extra hepatic cancer) in patients with NAFLD. We also briefly discuss the impact of the heterogeneity of the clinical phenotype of NAFLD on the clinical practice globally and at the individual level.

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