scholarly journals Stable Allele Frequency Distribution of the Plasmodium falciparum clag Genes Encoding Components of the High Molecular Weight Rhoptry Protein Complex

2012 ◽  
Vol 40 (3) ◽  
pp. 71-77 ◽  
Author(s):  
Jean Semé Fils Alexandre ◽  
Phonepadith Xangsayarath ◽  
Morakot Kaewthamasorn ◽  
Kazuhide Yahata ◽  
Jetsumon Sattabongkot ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Plasmodium Falciparum ◽  
High Molecular Weight ◽  
Allele Frequency ◽  
Frequency Distribution ◽  
Protein Complex ◽  
Allele Frequency Distribution ◽  
Genes Encoding ◽  
Rhoptry Protein

scholarly journals STATISTICAL STUDIES ON PROTEIN POLYMORPHISM IN NATURAL POPULATIONS. III. DISTRIBUTION OF ALLELE FREQUENCIES AND THE NUMBER OF ALLELES PER LOCUS

Genetics ◽  
1980 ◽  
Vol 94 (4) ◽  
pp. 1039-1063
Author(s):  
Ranajit Chakraborty ◽  
Paul A Fuerst ◽  
Masatoshi Nei
Keyword(s):  
Molecular Weight ◽  
Allele Frequency ◽  
Frequency Distribution ◽  
Gene Frequency ◽  
Natural Populations ◽  
Allele Frequencies ◽  
Protein Polymorphism ◽  
Allele Frequency Distribution ◽  
Wide Range ◽  
Rare Alleles

ABSTRACT With the aim of understanding the mechanism of maintenance of protein polymorphism, we have studied the properties of allele frequency distribution and the number of alleles per locus, using gene-frequency data from a wide range of organisms (mammals, birds, reptiles, amphibians, Drosophila and non-Drosophila invertebrates) in which 20 or more loci with at least 100 genes were sampled. The observed distribution of allele frequencies was U-shaped in all of the 138 populations (mostly species or subspecies) examined and generally agreed with the theoretical distribution expected under the mutation-drift hypothesis, though there was a significant excess of rare alleles (gene frequency, 0 ~ 0.05) in about a quarter of the populations. The agreement between the mutation-drift theory and observed data was quite satisfactory for the numbers of polymorphic (gene frequency, 0.05 ~ 0.95) and monomorphic (0.95 ~ 1.O) alleles.—The observed pattern of allele-frequency distribution was incompatible with the prediction from the overdominance hypothesis. The observed correlations of the numbers of rare alleles, polymorphic alleles and monomorphic alleles with heterozygosity were of the order of magnitude that was expected under the mutation-drift hypothesis. Our results did not support the view that intracistronic recombination is an important source of genetic variation. The total number of alleles per locus was positively correlated with molecular weight in most of the species examined, and the magnitude of the correlation was consistent with the theoretical prediction from mutation-drift hypothesis. The correlation between molecular weight and the number of alleles was generally higher than the correlation between molecular weight and heterozygosity, as expected.

scholarly journals Stable allele frequency distribution of the polymorphic region of SURFIN4.2 in Plasmodium falciparum isolates from Thailand

2012 ◽  
Vol 61 (2) ◽  
pp. 317-323 ◽  
Author(s):  
Morakot Kaewthamasorn ◽  
Kazuhide Yahata ◽  
Jean Semé Fils Alexandre ◽  
Phonepadith Xangsayarath ◽  
Shusuke Nakazawa ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Allele Frequency ◽  
Frequency Distribution ◽  
Allele Frequency Distribution ◽  
Polymorphic Region

scholarly journals High molecular weight insulin-like growth factor binding protein complex

1989 ◽  
Vol 264 (20) ◽  
pp. 11843-11848
Author(s):  
R C Baxter ◽  
J L Martin ◽  
V A Beniac
Keyword(s):  
Molecular Weight ◽  
Growth Factor ◽  
High Molecular Weight ◽  
Protein Complex ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Characterization of the major antigens of Haemophilus equigenitalis (contagious equine metritis organism)

1982 ◽  
Vol 89 (3) ◽  
pp. 529-538 ◽  
Author(s):  
M. J. Corbel ◽  
R. A. Brewer
Keyword(s):  
Molecular Weight ◽  
Cell Surface ◽  
High Molecular Weight ◽  
Protein Complex ◽  
Surface Antigens ◽  
Serological Response ◽  
Contagious Equine Metritis ◽  
Healthy Cattle ◽  
Apparently Healthy

SummaryImmunoelectrophoresis of ultrasonically disrupted Haemophilus equigenitalis (contagious equine metritis organism) cells against rabbit and equine antisera disclosed at least 11 precipitating antigens. Two of these, a polysaccharide and a lipopolysaccharide–protein complex, were of high molecular weight and located on the cell surface. The remaining antigens were intracellular and were small- to medium-sized proteins.The surface antigens were the most significant in relation to the serological response in infected horses. They also reacted with sera from apparently healthy cattle, but the reason for this was not determined. No serological cross-reaction between H. equigenitalis and species of Achromobacter and Moraxella was detected.

Serotonin transporter gene 5-HTTLPR VNTR allele frequency distribution in Africa and Eurasia

2016 ◽  
Vol 6 (2) ◽  
pp. 178-190
Author(s):  
A. S. Gureyev ◽  
A. A. Kim ◽  
Ye. D. Sanina ◽  
V. I. Shirmanov ◽  
V. A. Koshechkin ◽  
...  
Keyword(s):  
Allele Frequency ◽  
Frequency Distribution ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Allele Frequency Distribution ◽  
Transporter Gene

PCR analysis of genes encoding allelic variants of high-molecular-weight glutenin subunits at the Glu-D1 locus

1994 ◽  
Vol 88 (2) ◽  
pp. 175-180 ◽  
Author(s):  
R. D'Ovidio ◽  
E. Porceddu ◽  
D. Lafiandra
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Pcr Analysis ◽  
Glutenin Subunits ◽  
Allelic Variants ◽  
Genes Encoding

scholarly journals Genetic profiling of Vietnamese population from large-scale genomic analysis of non-invasive prenatal testing data

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ngoc Hieu Tran ◽  
Thanh Binh Vo ◽  
Van Thong Nguyen ◽  
Nhat-Thang Tran ◽  
Thu-Huong Nhat Trinh ◽  
...  
Keyword(s):  
Allele Frequency ◽  
Frequency Distribution ◽  
Genetic Variants ◽  
Large Scale ◽  
Genomic Analysis ◽  
Prenatal Testing ◽  
Allele Frequency Distribution ◽  
Genetic Studies ◽  
Non Invasive ◽  
Vietnamese Population

Abstract The under-representation of several ethnic groups in existing genetic databases and studies have undermined our understanding of the genetic variations and associated traits or diseases in many populations. Cost and technology limitations remain the challenges in performing large-scale genome sequencing projects in many developing countries, including Vietnam. As one of the most rapidly adopted genetic tests, non-invasive prenatal testing (NIPT) data offers an alternative untapped resource for genetic studies. Here we performed a large-scale genomic analysis of 2683 pregnant Vietnamese women using their NIPT data and identified a comprehensive set of 8,054,515 single-nucleotide polymorphisms, among which 8.2% were new to the Vietnamese population. Our study also revealed 24,487 disease-associated genetic variants and their allele frequency distribution, especially 5 pathogenic variants for prevalent genetic disorders in Vietnam. We also observed major discrepancies in the allele frequency distribution of disease-associated genetic variants between the Vietnamese and other populations, thus highlighting a need for genome-wide association studies dedicated to the Vietnamese population. The resulted database of Vietnamese genetic variants, their allele frequency distribution, and their associated diseases presents a valuable resource for future genetic studies.

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