scholarly journals Сare pathways of children with acute rhinological symptoms

2021 ◽  
pp. 43-51
Author(s):  
E. P. Karpova ◽  
D. A. Tulupov
Keyword(s):  
Respiratory Diseases ◽  
Acute Otitis Media ◽  
Well Being ◽  
Symptomatic Therapy ◽  
Care Pathways ◽  
Upper Respiratory Tract ◽  
Nasal Decongestants ◽  
Number Of Patients ◽  
Acute Respiratory Diseases ◽  
Acute Rhinitis

Acute respiratory diseases are one of the most common reasons for visiting a doctor in pediatric practice. Most episodes of this pathology have a viral etiology, signs of inflammation from the upper respiratory tract and proceed with symptoms of acute rhinitis (acute nasopharyngitis). The most of episodes of acute rhinitis last no more than 10 days and end with the patient’s recovery. The most common complications of acute rhinitis in children are acute rhinosinusitis and acute otitis media. These diseases are often mild and rarely have complications. However, a large number of patients with acute respiratory diseases increases the likelihood of a situation in which the doctor will encounter a problem patient. The article proposes care pathways for practitioners to manage patients with acute rhinological symptoms lasting up to 10 days and from 10 days to 3 months. The care pathways are based on several key points. No1: each patient must be analyzed for the presence of alarming symptoms, upon detection of which the patient should be urgently hospitalized. No2: all patients should be dynamically observed by a doctor until complete recovery, the patient should not receive treatment without the supervision of a doctor. No3: the basis of treatment is drugs for symptomatic therapy, which are selected depending on the dominant symptom that has the greatest impact on the patient’s well-being. To eliminate nasal mucosal edema, it is rational to use nasal decongestants (original oxymetazoline) for children of all ages; the course and dosages are determined according to the age of the child. Antibacterial drugs should be prescribed strictly according to indications in the presence of convincing data for the bacterial etiology of the disease.

scholarly journals Metabiotic Medicine of Symbiotic Corynebacteria: Prevention, Treatment and Immunological Safety

2019 ◽  
Vol 18 (4) ◽  
pp. 59-66
Author(s):  
E. A. Shmeleva ◽  
A. E. Vershinin ◽  
S. S. Andina
Keyword(s):  
Therapeutic Efficacy ◽  
Respiratory Diseases ◽  
Risk Groups ◽  
Pathogenic Microorganisms ◽  
Upper Respiratory Tract ◽  
Human Immune System ◽  
Before And After ◽  
Leading Position ◽  
Acute Respiratory Diseases

Relevance.Acute respiratory diseases (ARD) occupy a leading position in infectious pathology. Patients who often suffer from the acute respiratory diseases, in most cases have an ENT pathology against the background of immunodeficiency state. Large groups of people are often affected by such diseases. As a rule, the causative agents of such diseases are pathogenic and conditionally pathogenic microorganisms. To solve this problem, therapeutic immunomodulatory vaccines have been proposed. The goal of such drugs is to enhance specific resistance to a large number of conditionally pathogenic microorganisms.Aims.The purpose of this work is to demonstrate the prophylactic, therapeutic efficacy and immunomodulating safety of a metabiotic preparation produced from symbiotic corynebacteria.Materials and methods.A medicine Kodivak, a structural component of the cell wall of the symbiotic corynebacterium (Corynebacterium diphtheriae (tox +) was used in the work. The study on long term Cd tox + bacteria carriers examined the therapeutic efficacy as well as immunomodulating safety of Kodivak compared with some vaccines.Results and discussion.All carriers who have undergone the treatment with Kodivak stopped the release of Cd tox +, which was confirmed by a bacteriological analysis, and the condition of the oropharynx corresponded to the physiological norm. The quantitative indicators of the content of lymphocytes in the blood of the long-term carriers of C. diphtheriae tox + were determined before and after the course of treatment with Kodivak. Selective immunocorrecting effect of Kodivak on the human immune system is shown. A comparative analysis of post-vaccination changes in the number of immunocompetent cells of patients immunized with different vaccines showed that medicines containing antigens that are responsible for pathogenicity stimulate the state of immunodeficiency at a certain stage. While Kodivak does not cause significant deviations in the composition of the subpopulation of lymphocytes from the physiological norm.Conclusions.The findings confirm the possibility and necessity of using Kodivak not only for the rehabilitation of long-term carriers, but also both for therapeutic and prophylactic purposes in the risk groups of ARD morbidity of microbial and viral etiology as well as a nonspecific immunomodulating agent for the restoration of microsymbiogenesis in the upper respiratory tract biotopes.

scholarly journals Complex therapy of acute respiratory diseases

2019 ◽  
pp. 91-97 ◽  
Author(s):  
N. V. Orlova
Keyword(s):  
Respiratory Diseases ◽  
Viral Infections ◽  
Bacterial Pathogen ◽  
Symptomatic Therapy ◽  
Time Treatment ◽  
Laboratory Confirmation ◽  
Rational Diagnosis ◽  
Acute Respiratory Diseases ◽  
Antitussive Drugs

Acute respiratory disease (ARD) is a common pathology. Untimely diagnosis and treatment, co-morbidities, old age and children under 1 year of age, pregnancy can increase the severity of the condition and lead to complications and death. According to IDSA recommendations, vaccination is an effective way to prevent complications and fatal influenza cases. Vaccination is primarily for people at risk of serious illness. In cases of suspected influenza, molecular diagnostics is recommended. At the same time, treatment of suspected influenza should be prescribed immediately, without waiting for laboratory confirmation of the diagnosis. Etiotropic treatment aimed at suppressing virus replication should be the first priority in the treatment of acute respiratory viral infections. Bacterial agents may be the primary cause of respiratory diseases or may complicate viral diseases. In the presence of a bacterial pathogen, antibacterial agents are prescribed. ARD symptoms worsen the quality of life of patients. Complex treatment of respiratory diseases includes the prescription of symptomatic therapy: antipyretics, antitussives, vasoconstrictor drugs in rhinorrhea. Cough is the most common respiratory symptom. In various diseases, cough has its own peculiarities, which allows you to carry out differential diagnosis. The American Thoracic Society has proposed schemes of differential search for acute and chronic coughs, which allow rational diagnosis of diseases. The use of antitussive drugs has its own peculiarities: when the cough is non-productive, drugs are prescribed to suppress cough, when the cough is productive - drugs are aimed at facilitating the evacuation of sputum. One of the preparations possessing expectorant, mucolytic and antispasmodic action, is Hedelix syrup on the basis of ivy.

Abstract 10: Effect of coincident infections in acute Kawasaki disease

Circulation ◽  
2015 ◽  
Vol 131 (suppl_2) ◽  
Author(s):  
Toshiaki Jibiki ◽  
Yuji Hashimoto ◽  
Masaki Kanazawa ◽  
Izumi Kato ◽  
Yoshinori Morita ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Clinical Course ◽  
Acute Otitis Media ◽  
Gastrointestinal Symptoms ◽  
Treatment Decision ◽  
Admission Diagnosis ◽  
Upper Respiratory Tract ◽  
Laboratory Findings ◽  
Number Of Patients ◽  
Acute Kawasaki Disease

We investigated prevalence of coincident infections in acute Kawasaki disease (KD) to know the possible effects of infections on diagnosis of KD, clinical course, therapy decision and coronary outcomes. Single center consecutive 344 KD patients hospitalized in our institution, between January 2009 and December 2013 were retrospectively analyzed. Patients those were positive for bacterial culture, rapid antigen tests or elevated levels of pathogen specific antibodies were counted as KD patients with infection. Pathogen unproven patients those presented with apparent respiratory or gastrointestinal symptoms regarding infections were also counted as KD patients not to underestimate number of patients with suspected infections. Overall, 125 KD patients were grouped as KD patients with infection (Group1). Group1 included 125 patients with 73 upper respiratory tract infection, 21 bronchitis, 7 pneumonia, 3 acute otitis media and 21 gastroenterocolitis, respectively. Remaining 219 KD patients were grouped as KD without infection (Group2). Appropriate antibiotic or antiviral treatments were done for each pathogen proven infection. Distribution of age and sex, day of admission, diagnosis and treatment, prevalence of initial treatment regimen and rate of additional therapy, duration of fever, laboratory findings except serum albumin value, and coronary outcomes were similar between the groups. We showed that presence of coincident infections have no effects on clinical course, treatment decision and coronary outcomes on KD.

scholarly journals The basic principle of pathogenetic therapy of purulent-inflammatory pathology of ENT organs

2021 ◽  
pp. 96-102
Author(s):  
A. V. Gurov ◽  
M. A. Yushkina
Keyword(s):  
Inflammatory Diseases ◽  
Acute Otitis Media ◽  
Clinical Manifestations ◽  
Vascular Wall ◽  
Similar Reaction ◽  
Special Role ◽  
Nasal Breathing ◽  
Nasal Decongestants ◽  
Pathogenetic Therapy ◽  
Acute Rhinitis

 The nature of the clinical manifestations of purulent-inflammatory diseases of the ENT organs is determined, first of all, by the localization of the process, and in addition, by the severity of the reactions of general and local inflammation. In this regard, the authors of the article propose to consider the main factors of pathogenesis that determine the sequence and relationship of the stages of the inflammatory response: edema, redness, fever, pain and dysfunction. A special role in the implementation of the regulatory mechanisms of inflammation belongs to active molecules, the so-called inflammatory mediators. The authors of the article consider the main cellular and plasma mediators, concluding that most of the effects they carry out are accompanied by a violation of the integrity of the vascular wall, exudation, edema and tissue swelling. A similar reaction is, in general, nonspecific and is observed in a number of inflammatory diseases of the ENT organs, such as acute rhinitis, allergic rhinitis, acute sinusitis, eustachitis, acute otitis media. This circumstance allows the authors to conclude that a local therapeutic effect is necessary on this particular link of pathogenesis. To this end, the authors of the article propose the use of nasal decongestants, drugs with an alpha-adrenomimetic effect, which effectively relieve swelling of the nasal mucosa and facilitate nasal breathing. In clinical practice, preparations based on xylometazoline have proven themselves well.

scholarly journals Efficiency of the irs-19 aerosol vaccine in children with relapsing diseases of upper respiratory tract

2021 ◽  
Vol 82 (1) ◽  
pp. 15-16
Author(s):  
G. A. Makovetskaya ◽  
V. V. Zhestkova ◽  
T. L. Kuznetsova
Keyword(s):  
Infectious Diseases ◽  
Respiratory Tract ◽  
Respiratory Diseases ◽  
Upper Respiratory Tract ◽  
Acute Respiratory Diseases ◽  
Upper Respiratory

The use of the IRS-19 aerosol vaccine results in decreasing of the rate of the infectious diseases of otorhinolaryngologic organs in children suffering from adenoids, sinusitis, complications of acute respiratory diseases.

scholarly journals ARIA guideline 2019: treatment of allergic rhinitis in the German health system

2019 ◽  
Vol 28 (7) ◽  
pp. 255-276 ◽  
Author(s):  
Ludger Klimek ◽  
Claus Bachert ◽  
Oliver Pfaar ◽  
Sven Becker ◽  
Thomas Bieber ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Health System ◽  
Integrated Care ◽  
Respiratory Diseases ◽  
Social Systems ◽  
Real Life ◽  
Care Pathways ◽  
Chronic Respiratory Diseases ◽  
Number Of Patients ◽  
Integrated Care Pathways

Abstract Background The number of patients affected by allergies is increasing worldwide. The resulting allergic diseases are leading to significant costs for health care and social systems. Integrated care pathways are needed to enable comprehensive care within the national health systems. The ARIA (Allergic Rhinitis and its Impact on Asthma) initiative develops internationally applicable guidelines for allergic respiratory diseases. Methods ARIA serves to improve the care of patients with allergies and chronic respiratory diseases. In collaboration with other international initiatives, national associations and patient organizations in the field of allergies and respiratory diseases, real-life integrated care pathways have been developed for a digitally assisted, integrative, individualized treatment of allergic rhinitis (AR) with comorbid asthma. In the present work, these integrated care pathways have been adapted to the German situation and health system. Results The present ICP (integrated care pathways) guideline covers key areas of the care of AR patients with and without asthma. It includes the views of patients and other healthcare providers. Discussion A comprehensive ICP guideline can reflect real-life care better than traditional guideline models.

scholarly journals Efficacy of combined antipyretic drug in the treatment of acute respiratory diseases

2017 ◽  
Vol 98 (2) ◽  
pp. 175-181
Author(s):  
O I Pikuza ◽  
R A Fayzullina ◽  
A M Zakirova ◽  
Kh M Vakhitov
Keyword(s):  
Single Dose ◽  
Respiratory Diseases ◽  
Well Being ◽  
Immunofluorescence Assay ◽  
Direct Immunofluorescence ◽  
Integral Scale ◽  
Results Of Treatment ◽  
Acute Respiratory Diseases ◽  
Group 2 ◽  
Treatment Safety

Aim. To evaluate efficacy of combined antipyretic drug in the treatment of acute respiratory diseases. Methods. 97 children aged 3 to 6 years admitted in 2014-2015 were observed. Children were divided into 3 groups: in group 1 (23 children) paracetamol with single dose 10 to 15 mg/kg was administered, in group 2 (36 children) ibuprofen (single dose 6-10 mg/kg) was used, in group 3 (38 patients) combined antipyretic drug (100 mg of paracetamol and 125 mg of ibuprofen) was administered with daily dose not exceeding 3 tablets for less than 3 days. Clinical and instrumental and laboratory studies were performed in all children, specialists’ consultations were administered if necessary. Compliance (number of refusal to take medication because of inefficacy, intolerance of a drug or dissatisfaction with organoleptic properties of a drug) was assessed by parents’ surveys. Satisfaction with the results of treatment with a combined drug was evaluated by patients’ parents by means of integral scale IMPSS. Verification of certain etiologic factors was performed by means of direct immunofluorescence assay of nasal smear. Results. As a result of the study it was found that among the etiologic factors of acute respiratory diseases of observed patients parainfluenza viruses and adenoviruses were predominant. When the combined drug was used, almost all parents were sure of children’s treatment safety. Administration of the combined drug was associated with faster and persistent fever reduction and decrease of children’s hospital stay. Due to long-term normal temperature when treated with combined drug children had better well-being, that positively influenced their sleep. In groups 1 and 2 with separately administered paracetamol and ibuprofen 28.3% of parents were unsatisfied with the medication while among the parents, whose children received a combination of ibuprofen and paracetamol, only 5.3% were unsatisfied (p

scholarly journals The relevance of the situational use of nasal decongestants in modern clinical practice

2021 ◽  
Vol 23 (9) ◽  
pp. 400-405
Author(s):  
Svetlana V. Morozova ◽  
◽  
Lina A. Keda ◽  
Keyword(s):  
Clinical Practice ◽  
Otitis Media ◽  
Active Ingredient ◽  
Clinical Studies ◽  
Acute Otitis Media ◽  
Endoscopic Examination ◽  
Symptomatic Therapy ◽  
Duration Of Action ◽  
Nasal Decongestants ◽  
Minimum Number

Nasal decongestants (ND) are representatives of the pharmacological group of α-adrenomimetics and are widely used in clinical practice. These drugs are successfully used as symptomatic therapy of acute rhinosinusitis (AR), as well as as part of the complex therapy of acute otitis during unloading therapy for the auditory tube. The use of ND is necessary before conducting an endoscopic examination of the nasal cavity, for a better assessment of the state of the ostiomeatal complex, the olfactory cleft, as well as differential diagnosis of various forms of rhinitis and dysosmia. ND are indispensable in the prevention of complications of AR, such as acute eustachiitis, exudative otitis media and acute otitis media. Also, these drugs are used in the prevention of the development of aerotitis and ear barotrauma. The most commonly used nasal medications of medium and long duration of action, such as xylometazoline and oxymetazoline. This article presents clinical studies demonstrating the high efficacy and safety of these drugs as part of the treatment of AR. It is shown that oxymetazoline and xylometazoline are well tolerated by patients with a minimum number of adverse events. Modern representatives of ND are such drugs as Otrivin express 0.05% with the aroma of menthol, the main active ingredient of which is oxymetazoline, Otrivin 0.1% Moisturizing formula and Otrivin 0.1% with menthol and eucalyptus, which includes xylometazoline as the main active ingredient. These drugs have confirmed their effectiveness and safety in a large number of clinical studies and can be recommended as local vasoconstrictors.

Evaluation of clinical efficacy of Derinat® in form of spray in practice of district therapist

2019 ◽  
Vol 1 (9) ◽  
pp. 38-46
Author(s):  
A. P. Babkin ◽  
A. A. Zuikova ◽  
O. N. Krasnorutskaya ◽  
Yu. A. Kotova ◽  
D. Yu. Bugrimov ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Respiratory Diseases ◽  
Viral Infections ◽  
Pharmacological Action ◽  
The Body ◽  
Natural Resistance ◽  
Acute Respiratory Diseases ◽  
T Helpers ◽  
T Killers ◽  
Stimulation Of

The widespread worldwide spread of acute respiratory diseases is an urgent problem in health care. Expressed polyetiology of respiratory diseases does not allow to limit the use of specific vaccine preparations and dictates the need to use to combat them a variety of non-specific means that stimulate the natural resistance of the human body. The main pharmacological action of sodium deoxyribonucleate is the stimulation of phagocytic activity of T-helpers and T-killers, increasing the functional activity of neutrophils and monocytes/ macrophages, providing regeneration and repair processes in the epithelial component of antiviral protection of the body. Based on the above, the study of the clinical efficacy of Derinat® in the form of spray in the treatment of acute respiratory viral infections is relevant.

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