scholarly journals Possibilities of daytime anxolytics in the correction of residual neurological manifestations of COVID-19

2021 ◽  
pp. 50-60
Author(s):  
E. A. Alexandrova ◽  
E. V. Parshina ◽  
I. V. Borodacheva ◽  
A. G. Suslov ◽  
K. M. Beliakov ◽  
...  
Keyword(s):  
Sleep Disorders ◽  
Cognitive Disorders ◽  
Underlying Disease ◽  
Average Score ◽  
Memory And Attention ◽  
End Of Treatment ◽  
Personal Anxiety ◽  
Coronavirus Infection ◽  
High Level

Introduction. In  addition to acute manifestations, coronavirus infection is characterized by long-lasting symptoms: asthenia, somatic vegetative manifestations, sleep disorders and psychoemotional background, the  question of  therapeutic correction of which is especially relevant.The aim of the study was to study the mental, somatoform and cognitive aspects of anxiety disorders after coronavirus infection during treatment with tofizopam (Grandaxin®) at 150 mg / day.Materials and methods. The study involved patients who had a new coronavirus infection, who 4 weeks after the end of treatment for the underlying disease had complaints that suggest the presence of an anxiety disorder. The Hamilton scale was used to assess the level of anxiety. The patients were examined before the start of treatment, after 2, 4 and 6 weeks of therapy.Results. Prior to the start of therapy, all patients had an overall high level of anxiety: the average HAM-A score was 31.72 ± 2.24  points. At the  end of  Grandaxin® therapy, all patients showed a  decrease in  the  level of  anxiety: the  average score for HAM-A was 12.68 ± 2.04 points (p < 0.001). At the end of the course of therapy, patients noted an increase in mental performance, improved memory and attention, that is, a decrease in the severity of cognitive disorders associated with anxiety was> distinct – the average score on the “cognitive disorders” subscale decreased three times – from 1.6 ± 0.12 to 0.5 ± 0.09 (p˂0.001).Conclusions. Disorders of the psychoemotional background (more often in the form of increased personal anxiety), sleep disorders, autonomic disorders, asthenic syndrome significantly affect the quality of life of patients who have suffered a new coronavirus infection. A comprehensive approach is needed in the clinical diagnosis of the long-term consequences of a new coronavirus infection and their subsequent correction with drug therapy. 

scholarly journals Anti-relapse therapy of endometriosis: possible variations

2021 ◽  
pp. 38-42
Author(s):  
N.F. Zakharenko ◽  
S.I. Regeda ◽  
I.P. Manoliak ◽  
V.S. Solskyy
Keyword(s):  
Hormonal Treatment ◽  
Clinical Effectiveness ◽  
Pathological Process ◽  
Average Score ◽  
Extragenital Endometriosis ◽  
Group 2 ◽  
High Level ◽  
Relapse Therapy ◽  
Group 1

Research aim: to determine the clinical efficacy and safety of bioavailable curcumin Longimin® in the complex anti-relapse therapy of patients with extragenital endometriosis after surgery.Materials and methods. Study involved 45 women with a mean age of 29.3 ± 3.6 years with a diagnosis of extragenital endometriosis. After surgical treatment of this disease all patients were prescribed dienogest 2 mg/day for 6 months with anti-relapse purpose. After that, 22 patients did not receive drug treatment (group 1) and other 23 women started a six-month course of 400 mg bioavailable curcumin (group 2).Results. After 12 months of observation 3 cases (13.6%) of newly formed foci of endometriosis were found among patients of group 1, two of which were multi-endometriomas, and the third was retrocervical heterotopia. There were no signs of recurrence in the group of sequential use of dienogest and bioavailable curcumin. In addition, 6 months after completion of hormonal treatment the number of women with chronic pelvic pain in group 1 was increased and average score on a visual analogue scale (VAS) was increased by 80% (p ≤0.05). It was accompanied by a stable moderately high level of anxiety throughout the observation period. At the same time the number of women who complained of intermenstrual pain in group 2 decreased from 15 to 13, and the average VAS score decreased by 13% (p ≥0.05) during the treatment period. Patients in group 2 noted an improvement in emotional control during treatment, which resulted in the average score decrease on the scale of personal and situational anxiety of the Spielberg-Hanin's questionnaire (25% and 30% respectively, p ≤0.05).Conclusions. The nature of the endometriosis development and progression is multipathogenetic. Blocking only its hormonal link, especially in cases of extragenital forms, may not be sufficient to stop the pathological process and prevent recurrence in the long term. Оbtained results of sequential course of dienogest and bioavailable curcumin Longimin® with anti-relapse purpose showed the wider clinical effectiveness of this therapy, which is probably based on additional inhibition of systemic inflammation, proliferation, stroma and psychogenic component of disease.

Osteopathic status in patients with new coronavirus infection COVID-19

2021 ◽  
pp. 18-28
Author(s):  
V. O. Belash ◽  
N. A. Lisenkova
Keyword(s):  
Medical Care ◽  
Cross Sectional Study ◽  
Medical Documentation ◽  
Cross Sectional ◽  
Acute Period ◽  
Personal Anxiety ◽  
Coronavirus Infection ◽  
Rehabilitation Measures ◽  
High Level ◽  
Coronavirus Infections

Introduction. The appearance of COVID-19 has set tasks for healthcare professionals related to the rapid diagnosis and provision of medical care to patients. Currently, intensive study of the clinical and epidemiological features of the disease continues, and of the development of new means of its prevention and treatment. At the same time, it is necessary not only to provide medical care in the acute period of the disease, but also to carry out rehabilitation measures for the consequences of a coronavirus infection. In accordance with the approved clinical recommendations, osteopathic correction in the acute period of an infectious disease is contraindicated. However, there is a potential interest of the possibility of osteopathic correction methods use during the period of convalescence, as well as within the framework of rehabilitation measures after a new coronavirus infection.At the same time, for objective reasons, there is no data on the structure of somatic dysfunctions in this group of patients in the literature. All of the above has predetermined the purpose of the research.The aim of the study is to draw up a map of the most common somatic dysfunctions and analyze their relationship with other subjective and objective manifestations of the disease based on the data of the osteopathic status assessing of patients who have undergone a new coronavirus infection COVID-19.Materials and methods. A cross-sectional study was conducted on the basis of Samara medical and sanitary unit № 2 and on the basis of the Saint-Petersburg «City Mariinsky Hospital» in the period from May 2020 to March 2021. There were 70 patients under observation in the rehabilitation department who had undergone a new coronavirus infection COVID-19. There were assessed the osteopathic status of all patients (by an osteopathic doctor with using personal protective equipment) and the level of anxiety; the data was copied from medical documentation.Results. Somatic dysfunctions of all three levels of manifestation are revealed in patients with the new coronavirus infections during the convalescence period. The global and regional somatic dysfunctions were distributed almost equally (45,7 and 54,3 %, respectively) in the structure of dominant somatic dysfunctions in patients with new coronavirus infections during the convalescence period. Patients with new coronavirus infections during the convalescence period are characterized by medium and high levels of both situational and personal anxiety. In the course of the work, a moderate positive relationship was established between a global rhythmogenic disorder (violation of the production of a thoracic rhythmic pulse) and a large volume of lung tissue damage (CT-2) according to the multispiral computed tomography of the thoracic cavity, as well as between a global psychoviscerosomatic disorder and a high level of situational anxiety.Conclusion. Somatic dysfunctions of all three levels of manifestation are revealed in patients with new coronavirus infections during the convalescence period. In addition, this group of patients is characterized by an average and high level of both situational and personal anxiety.The revealed correlations suggest that the inclusion of osteopathic correction in comprehensive rehabilitation programs for this group of patients may be pathogenetically reasonable.

scholarly journals Patient’s anxiety at the different stages of genesis of myocardial infarction

2020 ◽  
pp. 75-86
Author(s):  
Ruslan Vasitovich Kadyrov ◽  
Anastasiya Sergeevna Elzesser ◽  
Natal'ya Sergeevna Bartkovskaya
Keyword(s):  
Myocardial Infarction ◽  
Hospital Treatment ◽  
Course Of Disease ◽  
Situational Anxiety ◽  
Personal Anxiety ◽  
The Subject ◽  
Observational Group ◽  
High Level

The subject of this research is the anxiety of patients at different stages of genesis of myocardial infarction (MI). It is a proven fact that the high level of anxiety leads to reoccurrence and unfavorable course of disease both, in combination with other factors or regardless of them. However, the influence of separate aspects of anxiety into reoccurrence of MI remains insufficiently studied, which actualizes determination of the components of anxiety at different staged of emergence of this disease. The article presents a comparative analysis and description of the level of manifestation of various components of anxiety among the following empirical groups: 33 persons without myocardial infarction in past medical history, but in the group of risk by its genesis; 29 patients undergoing 2 to 5 days of hospital treatment for recovering after MI; 27 patients that have already received post-hospital therapy after MI. The observational group included 30 technically healthy persons. The following conclusions are formulated: 1) Anxiety components, such as asthenic, phobic, emotional discomfort are vivid among the patients who have survived MI, as well as persons in the risk group. However, an additional longitude research is required for proving the influence of anxiety into the genesis of myocardial infarction. 2) The currently conducted rehabilitation of MI patients reduces the overall level of situational anxiety, practically avoiding such its components that in the future can prompt recurrence of MI. 3) High level of anxiety is characteristic to all IM patients. The recommended programs for prevention and rehabilitation should be focused on long-term reduction of the level of personal anxiety, such as cognitive-behavioral psychotherapy.

scholarly journals 15-year risk of developing type 2 diabetes mellitus and its relationship with personal anxiety, sleep disturbance among men 45-69 years old in Russia /Siberia (international epidemiological study “HAPIEE”)

2020 ◽  
Vol 23 (3) ◽  
pp. 204-209
Author(s):  
V. V. Gafarov ◽  
E. A. Gromova ◽  
D. O. Panov ◽  
S. V. Mustafina ◽  
L. V. Shcherbakova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Sleep Disorders ◽  
Epidemiological Study ◽  
Cox Regression ◽  
Statistical Significance ◽  
Personal Anxiety ◽  
High Level ◽  
Dm Type 2

BACKGROUND:Determine the effect of personal anxiety, sleep disorders on the 15-year risk of developing (RR) diabetes mellitus (DM) type 2 among men (M) 45-69 years in Russia / Siberia (Novosibirsk). METHODS:In 20032005 As part of the IV screening of the international epidemiological study HAPIEE, a representative sample of m 4569 years was examined (n=781 M, mean age-56.480.20 years, response 61.00%). The level of personal anxiety (PA) was assessed using the Spielberger scale (HPA high, MPA medium, LPA low). With the help of the scale Knowledge and attitude to ones health, the level of sleep disorders (SD) was assessed. The period of observation of the cohort was 15 years. To check the statistical significance of the differences between the groups, the Pearson 2test was used. For risk assessment, Cox-regression single-factor and multivariate regression proportional hazards model was used (Cox-regression). RESULTS:Among persons with the first occurrence of DM type 2, HPA at the screening was 59.50%, and 63.30% had SD. The combination of HPA and SD was significant among M with the first-onset diabetes mellitus. During the 15-year period, among M with HLA, the risk of developing type 2 diabetes was 1.60 times higher than without. Among people with SD, therisk of developing type 2 diabetes was 2.40 times higher than without. In Cox the proportional multifactor model, each variable had its own independent influence. HPA increased the RR DM of the 2nd type by 1.90 times, and SD by 2.80 times. CONCLUSION:It was established that a high level of PA and SD are independent predictors of type 2 diabetes, moreover, with SD, the risk of developing type 2 diabetes is higher than with a high level of PA.

Clinical and neurophysiological correlations in post-Covid‑19 patients and rationale for pathogenetic therapy

2021 ◽  
pp. 7-11
Author(s):  
M. G. Sokolova ◽  
M. A. Privalova ◽  
V. A. Shavurov ◽  
O. Yu. Shtakelberg ◽  
E. V. Lopatina ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Endothelial Damage ◽  
Pathological Effect ◽  
Pathogenetic Therapy ◽  
Personal Anxiety ◽  
The Central Nervous System ◽  
Coronavirus Infection ◽  
High Level ◽  
Selection Of

Clinical and neurological, neurophysiological, and neuropsychological examination of 50 patients aged 50–65 y. o. with an experience of COVID‑19 infection within the last 3 to 6 months, revealed pathological changes in the central nervous system in the form of cerebrastenic and autonomic disorders, motor disorders, vestibulopathy symptoms, which occurred in various combinations, with astheno-vegetative syndrome as obligate. Cognitive impairments were detected in 26% of patients; the mental fatigability index was 1.055 ± 0.124; a high level of situational anxiety was noted in 35% of patients, and a high level of personal anxiety in 50 % of patients with the experience of COVID‑19. The study of brain biopotentials revealed moderate diffuse changes (18%) and irritative disorders on the part of hypothalamic (69 %) and diencephalic structures (20%). All of the above may indicate that, regardless of the form of coronavirus infection occurred in humans, i. e., latent, mild, moderate or severe, one of the targets of the pathological impact of COVID‑19 virus is the median structures of the brain responsible for autonomic and cognitive functions. Nevertheless, in our opinion, these disorders are associated not with a direct pathological effect, but are mediated mainly by circulatory disorders in the microcirculatory bed due to endothelial damage and are rather functional disorders on the part of the central nervous system. This provides the grounds for the selection of pathogenetic therapy aimed at stabilizing the functional state of neurons, and one of the drugs of choice may be citicoline (Noocyl), the action of which is associated with reinforcing the cell membrane of the neuron and normalizing bioelectric processes.

scholarly journals REMOTE CONSEQUENCES OF PESTICIDE POLLUTION ON THE LEVEL OF DEVELOPMENT OF COGNITIVE FUNCTIONS

REPORTS ◽  
2020 ◽  
Vol 5 (333) ◽  
pp. 118-124
Author(s):  
U.N. Kapysheva ◽  
◽  
Sh.K. Bakhtiyarova ◽  
A.K. Baimbetova ◽  
◽  
...  
Keyword(s):  
Cognitive Functions ◽  
Cognitive Abilities ◽  
Short Term Memory ◽  
Memory Capacity ◽  
Short Term ◽  
Term Memory ◽  
Memory And Attention ◽  
Pesticide Pollution ◽  
High Level

The purpose of this study is to identify the characteristics of the state of short-term memory, sustainability and concentration of attention among rural residents living in places of long-term pesticidal pollution. The study of cognitive functions in residents was performed using the special Neurosoft computer base program. A significant decrease (by 20%) in the number of people with a high level of development of short-term memory by numbers and images was revealed. An increase of 18% in the number of people with poorly developed cognitive abilities is shown both when remembering information on numbers and images, as well as when concentration and stability of attention is on the desired object. At the same time, the memory capacity of residents with a high level of development of the function of memorizing information, both for numbers and images, was at the same level as the benchmarks and ranged from 61% to 67% of the amount of information proposed for memorization. The study showed that living in a zone of long-term pesticidal pollution worsens cognitive functions - memory and attention, upsets the balance of the main nervous processes - excitation and inhibition, and increases the risk of developing nervous disorders.

scholarly journals ESTIMATION OF THE QUALITY OF COMPOSITE RESTORATION DEPENDING ON THE ABRASIVITY OF POLISHING PASTS

2021 ◽  
Vol 17 (2) ◽  
pp. 57-61
Author(s):  
Ol'ga Uspenskaya ◽  
Saniya Spiridonova
Keyword(s):  
Underlying Disease ◽  
Comparative Assessment ◽  
Dental Restoration ◽  
Maximum Value ◽  
End Of Treatment ◽  
Light Curing ◽  
Anterior Group ◽  
Composite Restoration

Introduction. Psychological comfort is one of the most important components in the formation of a healthy, full-fledged personality. The requirements of patients to the dentist are not only not limited to the treatment of the underlying disease and the successful restoration of lost functions, but also include the achievement of a good aesthetic effect — patients highly appreciate a beautiful, relief and at the same time smooth restoration. Thus, the relevance of dental restoration is acquiring not only medical significance, but also social connotation. The aim of the work was to carry out a comparative assessment of the quality of the composite restoration using polishing pastes of various abrasiveness. Material and methods. The study involved 60 patients of both sexes, aged 18-43 years, who underwent aesthetic restoration in the area of the anterior group of teeth of 4 and 5 classes according to Black's classification using the light-curing composite material Enamel plus HRi UD5. The observation was carried out in the immediate and long-term periods (12 months after the end of treatment). For finishing the restorations, we used Cleanic, Flairesse, Clean Polish and Enamel Shinec polishing pastes with different RDA indices. The patients were divided into 4 groups depending on the polishing paste used. Results and its discussion. As a result of the study, it was revealed that the RDA index of polishing pastes plays an important role in finishing, exerting great importance on the smoothness of the restoration, "dry shine" and allows to achieve better marginal adaptation of the material and better color fastness of the restoration. Conclusions. Thus, our study revealed the best result in the paste with the maximum value of RDA (83) — Flaresse (DMG).

Comparison of Auditory, Language, Memory, and Attention Abilities in Children With and Without Listening Difficulties

2020 ◽  
Vol 29 (4) ◽  
pp. 710-727
Author(s):  
Beula M. Magimairaj ◽  
Naveen K. Nagaraj ◽  
Alexander V. Sergeev ◽  
Natalie J. Benafield
Keyword(s):  
Auditory Processing ◽  
Short Term Memory ◽  
Group Differences ◽  
Long Term Memory ◽  
Short Term ◽  
Significant Group ◽  
Term Memory ◽  
Memory And Attention ◽  
Speed And Accuracy

Objectives School-age children with and without parent-reported listening difficulties (LiD) were compared on auditory processing, language, memory, and attention abilities. The objective was to extend what is known so far in the literature about children with LiD by using multiple measures and selective novel measures across the above areas. Design Twenty-six children who were reported by their parents as having LiD and 26 age-matched typically developing children completed clinical tests of auditory processing and multiple measures of language, attention, and memory. All children had normal-range pure-tone hearing thresholds bilaterally. Group differences were examined. Results In addition to significantly poorer speech-perception-in-noise scores, children with LiD had reduced speed and accuracy of word retrieval from long-term memory, poorer short-term memory, sentence recall, and inferencing ability. Statistically significant group differences were of moderate effect size; however, standard test scores of children with LiD were not clinically poor. No statistically significant group differences were observed in attention, working memory capacity, vocabulary, and nonverbal IQ. Conclusions Mild signal-to-noise ratio loss, as reflected by the group mean of children with LiD, supported the children's functional listening problems. In addition, children's relative weakness in select areas of language performance, short-term memory, and long-term memory lexical retrieval speed and accuracy added to previous research on evidence-based areas that need to be evaluated in children with LiD who almost always have heterogenous profiles. Importantly, the functional difficulties faced by children with LiD in relation to their test results indicated, to some extent, that commonly used assessments may not be adequately capturing the children's listening challenges. Supplemental Material https://doi.org/10.23641/asha.12808607

Vivid Imagers Are Better at Detecting Salient Changes

2006 ◽  
Vol 27 (4) ◽  
pp. 218-228 ◽  
Author(s):  
Paul Rodway ◽  
Karen Gillies ◽  
Astrid Schepman
Keyword(s):  
Individual Differences ◽  
Change Detection ◽  
Visual Imagery ◽  
Detection Task ◽  
Level Of Detail ◽  
Detection Accuracy ◽  
Change Detection Task ◽  
Term Change ◽  
High Level

This study examined whether individual differences in the vividness of visual imagery influenced performance on a novel long-term change detection task. Participants were presented with a sequence of pictures, with each picture and its title displayed for 17  s, and then presented with changed or unchanged versions of those pictures and asked to detect whether the picture had been changed. Cuing the retrieval of the picture's image, by presenting the picture's title before the arrival of the changed picture, facilitated change detection accuracy. This suggests that the retrieval of the picture's representation immunizes it against overwriting by the arrival of the changed picture. The high and low vividness participants did not differ in overall levels of change detection accuracy. However, in replication of Gur and Hilgard (1975) , high vividness participants were significantly more accurate at detecting salient changes to pictures compared to low vividness participants. The results suggest that vivid images are not characterised by a high level of detail and that vivid imagery enhances memory for the salient aspects of a scene but not all of the details of a scene. Possible causes of this difference, and how they may lead to an understanding of individual differences in change detection, are considered.

Influence of negative aff ectivity, social suppression and anxiety on motivation for health and a healthy lifestyle in coal industry workers

2020 ◽  
pp. 354-358
Author(s):  
I. P. Danilov ◽  
N. I. Vlakh ◽  
V. I. Gugushvili ◽  
N. Ya. Paneva ◽  
T. D. Logunova
Keyword(s):  
Working Conditions ◽  
Occupational Diseases ◽  
Healthy Lifestyle ◽  
Coal Industry ◽  
Type D ◽  
Situational Anxiety ◽  
Personal Anxiety ◽  
High Level ◽  
Level Of Motivation ◽  
Social Suppression

Introduction. A healthy lifestyle is one of the most eff ective methods of preserving health and preventing non-infectious diseases. The mechanisms and factors that infl uence the formation of motivation for health and a healthy lifestyle in employees engaged in harmful working conditions have not been suffi ciently studied. The study of these mechanisms will allow us to more eff ectively shape health-saving behavior.The aim of the study is to study negative aff ectivity, social suppression and anxiety in the formation of motivation to maintain health and a healthy lifestyle in coal industry workers.Materials and methods. A survey was conducted of 75 employees of mines and sections in the South of Kuzbass with an established diagnosis of occupational diseases, as well as 54 people who do not work in harmful working conditions (engineering and technical workers). Surveys were conducted using the method “Index of motivation to health and a healthy lifestyle”, the presence of personality type D was conducted using the DS14 questionnaire, the level of personal and situational anxiety was assessed using the Spielberger — Hanin questionnaire.Results. Th e level of motivation for health and a healthy lifestyle among patients with occupational diseases is signifi cantly lower than the level of motivation for the health of engineering and technical workers. Th e infl uence of negative reaction and social suppression on the level of motivation for health and a healthy lifestyle was not found. Th e level of situational anxiety also has no eff ect on health motivation. A higher level of personal anxiety among people with a high level of motivation for a healthy lifestyle was determined.Conclusions. Personal anxiety aff ects the level of motivation for health and a healthy lifestyle in people with occupational diseases. 

Sign in / Sign up

Export Citation Format

Share Document