Clinical and neurophysiological correlations in post-Covid‑19 patients and rationale for pathogenetic therapy

2021 ◽  
pp. 7-11
Author(s):  
M. G. Sokolova ◽  
M. A. Privalova ◽  
V. A. Shavurov ◽  
O. Yu. Shtakelberg ◽  
E. V. Lopatina ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Endothelial Damage ◽  
Pathological Effect ◽  
Pathogenetic Therapy ◽  
Personal Anxiety ◽  
The Central Nervous System ◽  
Coronavirus Infection ◽  
High Level ◽  
Selection Of

Clinical and neurological, neurophysiological, and neuropsychological examination of 50 patients aged 50–65 y. o. with an experience of COVID‑19 infection within the last 3 to 6 months, revealed pathological changes in the central nervous system in the form of cerebrastenic and autonomic disorders, motor disorders, vestibulopathy symptoms, which occurred in various combinations, with astheno-vegetative syndrome as obligate. Cognitive impairments were detected in 26% of patients; the mental fatigability index was 1.055 ± 0.124; a high level of situational anxiety was noted in 35% of patients, and a high level of personal anxiety in 50 % of patients with the experience of COVID‑19. The study of brain biopotentials revealed moderate diffuse changes (18%) and irritative disorders on the part of hypothalamic (69 %) and diencephalic structures (20%). All of the above may indicate that, regardless of the form of coronavirus infection occurred in humans, i. e., latent, mild, moderate or severe, one of the targets of the pathological impact of COVID‑19 virus is the median structures of the brain responsible for autonomic and cognitive functions. Nevertheless, in our opinion, these disorders are associated not with a direct pathological effect, but are mediated mainly by circulatory disorders in the microcirculatory bed due to endothelial damage and are rather functional disorders on the part of the central nervous system. This provides the grounds for the selection of pathogenetic therapy aimed at stabilizing the functional state of neurons, and one of the drugs of choice may be citicoline (Noocyl), the action of which is associated with reinforcing the cell membrane of the neuron and normalizing bioelectric processes.

scholarly journals The role of personal anxiety in the development of psychophysiological indicators in adolescent athletes

2021 ◽  
Vol 10 (4) ◽  
pp. 30-36
Author(s):  
A. A. Makarova ◽  
O. A. Kharkova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Reaction Time ◽  
Cognitive Behavioral Therapy ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Adolescent Athletes ◽  
Personal Anxiety ◽  
The Central Nervous System ◽  
High Level

Objective: to study the role of personal anxiety in the development of psychophysiological indicators in adolescent athletes.Materials and methods. To study the prevalence of high levels of personal anxiety (hereinafter — LT), as well as to determine the characteristics of psychophysiological indicators, the study involved 23 teenagers — boys and girls who were representatives of different sports. Using the device for psychophysiological testing UPFT-1/30 “Psychophysiologist”, indicators of simple visual-motor reaction and the level of LT on the Spielberg scale were obtained. To assess the impact of changes in high LT levels on psychophysiological indicators, 14 adolescent athletes with a high level of personal anxiety were selected and then divided into 2 groups. The experimental group included adolescents who wanted to participate in an experiment on the use of cognitive behavioral therapy techniques to correct high LT levels; the control group included adolescents with high LT levels who were not trained in cognitive behavioral therapy techniques.Results. Every third adolescent athlete had a high level of LT. Adolescent athletes with a high LT level, in contrast to adolescents with an optimal LT level, were less efficient, and, despite a shorter minimum reaction time, made more mistakes. The dynamics of psychophysiological indicators were observed both in the group with intervention and in the group where no cognitive behavioral therapy techniques were performed; however, after studying the difference in the physiological parameters of the central nervous system in the group where there was a change in LT, and in the group where LT either did not change or increased, we found positive changes. Changes in the LT level led to a decrease in the average reaction time, the minimum reaction time, and an increase in the level of stability of reactions.Conclusions. A high level of LT affects the psychophysiological parameters of the central nervous system in adolescent athletes. The use of cognitive behavioral therapy techniques to normalize the LT level of adolescent athletes leads to an improvement in the physiological parameters of the central nervous system.

scholarly journals The incidence and pathophysiology of neurological symptoms in COVID-19

2021 ◽  
Vol 40 (4) ◽  
pp. 33-42
Author(s):  
Igor V. Litvinenko ◽  
Miroslav M. Odinak ◽  
Nikolay V. Tsygan ◽  
Aleksander V. Ryabtsev
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rare Complication ◽  
Cranial Nerves ◽  
Neurological Symptoms ◽  
Immune Mediated ◽  
High Incidence ◽  
The Central Nervous System ◽  
Coronavirus Infection

The central nervous system seems to be quite vulnerable to SARS-CoV-2, leading to a variety of alteration pathways, high incidence and variability of the neurological symptoms of COVID-19. The COVID-19 symptoms, possibly associated with alteration to the central nervous system, include hyperthermia, shortness of breath, fatigue, headache, dizziness, dysphonia, dysphagia, hyposmia and anosmia, hypogeusia and ageusia, impairment of consciousness. The impairment of olfaction and gustation are the most common symptoms of the nervous system alteration (98% and 70%, respectively), which is most likely a consequence of the alteration of the receptors. Presumably the pathogenesis of dysphonia and dysphagia may involve neurodegenerative mechanisms or may be associated with a predominantly demyelinating alteration of the caudal cranial nerves. Pathomorphological findings in the brain of the COVID-19 patients include diffuse hypoxic and focal ischemic injuries of various sizes up to ischemic infarctions (in thrombosis of large arteries); microangiopathy; vasculitis; diapedetic and confluent hemorrhages with possible progression to hemorrhagic infarctions and rarely intracerebral hematomas. Acute cerebrovascular accident worsens the course of COVID-19 and can worsen the clinical outcome, taking into account the mechanisms of the central nervous system alteration in highly contagious coronavirus infections (SARS-CoV, MERS, SARS-CoV-2), including embolism, hypoxia, neurodegeneration, systemic inflammatory response and immune-mediated alteartion to the nervous tissue. A fairly rare complication of coronavirus infection, however, acute myelitis requires attention due to the severity of neurological disorders. The literature data show high incidence and polymorphism of the symptoms of the central nervous system alteration, as well as the important role of the cerebrovascular and neurodegenerative pathogenesis of brain alteration in COVID-19, which is taken into account in examining and treating the patients with new coronavirus infection. (1 figure, bibliography: 61 refs)

scholarly journals Selection of 7-10 Years Old Children of Different Types of Constitution in Sport Swimming, Taking Into Account Their Psychological and Physiological Features

2017 ◽  
pp. 68-73 ◽  
Author(s):  
Vladimir Davydov ◽  
Anna Mankevich ◽  
Olga Morozova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Selection Procedure ◽  
Different Types ◽  
The Future ◽  
The Central Nervous System ◽  
Selection Of ◽  
Sports Selection

The article revealed the need to consider the psychophysiological parameters of the central nervous system of the children of schoolchildren in the selection and orientation of the sport swimming. The interrelation of features such as the schoolchild constitution and the activity of his central nervous system has been revealed. Presented conducted an extensive research of boys 7-10 years old and based on the analysis of selected types of the most successful, the algorithm is composed of sports selection procedure, revealing the specificity and individuality of each student, which increases the effectiveness of achieving high results in the future.

scholarly journals Antioxidant Defense Mechanisms in Erythrocytes and in the Central Nervous System

Antioxidants ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 46 ◽  
Author(s):  
Rafael Franco ◽  
Gemma Navarro ◽  
Eva Martínez-Pinilla
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Defense Mechanisms ◽  
Antioxidant Defense ◽  
Circulatory System ◽  
Reducing Power ◽  
Antioxidant Defense System ◽  
Age Related ◽  
The Central Nervous System ◽  
High Level

Differential antioxidant action is found upon comparison of organ/tissue systems in the human body. In erythrocytes (red blood cells), which transport oxygen and carbon dioxide through the circulatory system, the most important issue is to keep hemoglobin in a functional state that requires maintaining the haem group in ferrous (Fe2+) state. Conversion of oxidized Fe3+ back into Fe2+ in hemoglobin needs a special mechanism involving a tripeptide glutathione, glucose-6-phosphate dehydrogenase, and glucose and NADPH as suppliers of reducing power. Fava beans are probably a good resource to make the detox innate system more robust as the pro-oxidant molecules in this food likely induce the upregulation of members of such mechanisms. The central nervous system consumes more oxygen than the majority of human tissues, i.e., 20% of the body’s total oxygen consumption and, therefore, it is exposed to a high level of oxidative stress. This fact, together with the progressive age-related decline in the efficiency of the antioxidant defense system, leads to neuronal death and disease. The innate mechanism operating in the central nervous system is not well known and seems different to that of the erythrocytes. The strategies of antioxidant intervention in brain will be reviewed here.

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