scholarly journals Toxicopathological Impacts Of Chlorpyrifos On Sperm Qualities And Testicular Tissue Alterations And Their Modulation With Vitamin E And Zinc In Male Albino Rats

2020 ◽  
Vol 5 (2) ◽  
pp. 67-76
Author(s):  
Assi M.M.A. ◽  
Azab M.M.S. ◽  
Rawash Z.M.
Keyword(s):  
Vitamin E ◽  
Testicular Tissue ◽  
Albino Rats ◽  
Tissue Alterations

scholarly journals Nanonaringenin and Vitamin E Ameliorate Some Behavioral, Biochemical, and Brain Tissue Alterations Induced by Nicotine in Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Mohamed A. Kandeil ◽  
Eman T. Mohammed ◽  
Rania A. Radi ◽  
Fatma Khalil ◽  
Abdel-Razik H. Abdel-Razik ◽  
...  
Keyword(s):  
Vitamin E ◽  
Histopathological Examination ◽  
Behavioral Changes ◽  
Albino Rats ◽  
Cerebral Neurons ◽  
Short Memory ◽  
Prophylactic Use ◽  
Tissue Alterations ◽  
The Brain ◽  
Behavior And Cognition

Nicotine is the major alkaloid present in cigarettes that induces various biochemical and behavioral changes. Nanonaringenin (NNG) and vitamin E are antioxidants that are reported to mitigate serious impairments caused by some toxins and oxidants. Thus, we aimed to investigate the efficacy of NNG, vitamin E, and their combinations to ameliorate behavioral, biochemical, and histological alterations induced by nicotine in rats. Adult male albino rats were randomly grouped into six equal groups (10 rats/group): control, N (nicotine 1 mg/kg b.w./day S/C from 15th to 45th day, 5 days a week), NNG (25 mg/kg b.w./day orally for 45 days), N + NNG, N + E (nicotine + vitamin E 200 mg/kg b.w./day orally), and N + NNG + E (nicotine + NNG + vitamin E at the aforementioned doses). Behavioral tests were conducted on day 15 and 30 postnicotine injection, while memory tests, brain neurotransmitters, antioxidants, and histopathological examination were examined at day 30 only. As a result, nicotine impaired rats’ activity (hypoactivity and hyperactivity) and memory, induced anxiolytic and anxiogenic effects on rats, and altered neurotransmitters (acetylcholinesterase, serotonin, and dopamine), and redox markers (MDA, H2O2, GSH, and catalase) levels in brain homogenates. Thickening and congestion of the meninges and degeneration of the cerebral neurons and glia cells were observed. Cosupplementation with NNG, vitamin E, and their combination with nicotine was beneficial in the alleviation of activity impairments and improved short memory and cognition defects and exploratory behaviors. Our results indicate the antioxidant potential of NNG and vitamin E by modulating redox markers and neurotransmitters in the brain. Thus, data suggest that the prophylactic use of NNG, vitamin E, and/or their combination for (45 days) may have a successful amelioration of the disrupted behavior and cognition and biochemical and histopathological alterations induced by nicotine.

The toxicity of Indigofera enneaphylla L. in rats

1965 ◽  
Vol 16 (4) ◽  
pp. 713 ◽  
Author(s):  
LR Murray ◽  
T Moore ◽  
IM Sharman
Keyword(s):  
Vitamin E ◽  
Chemical Analysis ◽  
Young Male ◽  
Tocopheryl Acetate ◽  
Albino Rats ◽  
Liver Lesions ◽  
Feeding Trial ◽  
Microscopic Evidence ◽  
Nitropropionic Acid ◽  
Plant Chemical

The inclusion of 50% of dried Indigofera enneaphylla in the diet arrested the growth of young male albino rats, caused incoordination of their limbs, and was fatal to them. Microscopic evidence of liver cellular abnormality was consistently observed in rats fed on the plant. Chemical analysis of I. Enneaphylla indicated the presence of combined G-nitropropionic acid, paralleling the findings of other workers in respect of I. Spicata, which, in addition, produced liver lesions. Dried I. Enneaphylla contained about 12 p.p.m. of α-tocopherol. According to haemolysis tests, the poisoned rats were not deficient in vitamin E. The administration of liberal doses of α-tocopheryl acetate did not counteract the poisoning. In preliminary experiments, dosing with L-arginine appeared to be partially protective against poisoning by I. Enneaphylla. Autoclaving the dried plant, according to a single feeding trial, resulted in loss of toxicity.

scholarly journals Vitamin E and selenium administration synergistically mitigates ivermectin and doramectin-induced testicular dysfunction in male Wistar albino rats

2020 ◽  
Vol 124 ◽  
pp. 109841 ◽  
Author(s):  
Ahmed Ezzat Ahmed ◽  
Ali Alshehri ◽  
M.A. Al-Kahtani ◽  
Serag Eldin I. Elbehairi ◽  
Mohammed A. Alshehri ◽  
...  
Keyword(s):  
Vitamin E ◽  
Albino Rats ◽  
Testicular Dysfunction ◽  
Wistar Albino Rats

scholarly journals Study of the toxic effect and safety of vitamin E supplement in male albino rats after 30 days of repeated treatment

Heliyon ◽  
2019 ◽  
Vol 5 (10) ◽  
pp. e02645 ◽  
Author(s):  
Heba N.Gad EL-Hak ◽  
Eman E. ELaraby ◽  
Ahmed K. Hassan ◽  
Osama A. Abbas
Keyword(s):  
Vitamin E ◽  
Toxic Effect ◽  
Albino Rats ◽  
Repeated Treatment

Protective effect of N-acetylcysteine, caffeic acid and vitamin E on doxorubicin hepatotoxicity

2007 ◽  
Vol 26 (6) ◽  
pp. 519-525 ◽  
Author(s):  
A. Gokcimen ◽  
A. Cim ◽  
H.T. Tola ◽  
D. Bayram ◽  
A. Kocak ◽  
...  
Keyword(s):  
Vitamin E ◽  
Caffeic Acid ◽  
Control Group ◽  
Albino Rats ◽  
Central Vein ◽  
Protective Effects ◽  
Injection Group ◽  
Hepatocellular Damage ◽  
Group I ◽  
Significant Difference

The aim of this study was to compare the possible protective effects of N-acetylcysteine (NAC), caffeic acid (CAPE) and vitamin E (Vit-E) on doxorubicin-induced hepatotoxicity. Thirty-two male Wistar albino rats, weighing between 250 and 350 g were supplied and randomly divided into five groups. Animals in study groups were pretreated with a single dose of doxorubicin (Dox), which was administered intraperitoneally (i.p.). Control group (Group I) was treated with intraperitoneal saline injection. Group II did not received any antioxidant agent after the injection. Group III and Group IV were given CAPE and intraperitoneal vitamin E injection for eight days, respectively. Group V received NAC for eight days. The study was finished after 10 days. Tissue samples were collected from all animals and histopathological examination was performed. There was statistically significant difference between the experiment groups and controls by means of mononuclear cell infiltration and diameters of hepatic sinusoid, terminal hepatic venule (central vein) and portal area (portal canal). Changes related with hepatocellular damage were more prominent, whereas there was no significant difference between Dox and NAC given groups histopathologically. It was observed that structural changes were regressed after CAPE administration. However, this recovery was more prominent in vitamin E given group. These findings suggest that Dox induced liver damage could be efficiently reversed by vitamin E administration. It has been found that CAPE, but not NAC has protective effects on Dox-induced hepatocellular damage. Human & Experimental Toxicology (2007) 26, 519—525

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