Effect of Dietary Phytoestrogen; Genistein; on Improvement of the Immunity and other Biochemical Indices of Alloxan-induced Diabetic Rats

2003 ◽  
Vol 33 (2) ◽  
pp. 275-294
Author(s):  
Sohair Abd Elkhalek ◽  
Sherif Ragab
Keyword(s):  
Diabetic Rats ◽  
Biochemical Indices

scholarly journals Effects of methanol leaf extracts of Loranthus micranthus Linn from three host plants on some biochemical indices of diabetic rats

2018 ◽  
Vol 16 (12) ◽  
pp. 2919
Author(s):  
Uwakwe S Onoja ◽  
Innocent E Nweze ◽  
Nwachukwu Ekere ◽  
Philip F Uzor ◽  
Onyinyechi B Giginna
Keyword(s):  
Host Plants ◽  
Diabetic Rats ◽  
Leaf Extracts ◽  
Biochemical Indices

scholarly journals Impact of an Acylanilide Herbicide Propanil on Biochemical Indices in Kidney of Diabetic Rats

2019 ◽  
Vol 12 (2) ◽  
pp. 210-216 ◽  
Author(s):  
Chiagoziem Anariochi ◽  
Femi Ayoade ◽  
Oladeji John Arogu
Keyword(s):  
Diabetic Rats ◽  
Biochemical Indices ◽  
Herbicide Propanil

scholarly journals Amlodipine and valsartan improving effect on the survival rate and deleterious pathological changes in streptozotocin-induced diabetic rats treated with metformin

2019 ◽  
Author(s):  
Israel Olapeju Bolanle ◽  
Eric Kelly Inanemo Omogbai ◽  
Enitome Evi Bafor
Keyword(s):  
Survival Rate ◽  
Antihypertensive Drugs ◽  
Diabetic Rats ◽  
Organ Protection ◽  
Amlodipine Group ◽  
Male Wistar Rats ◽  
Diabetic Treatment ◽  
Biochemical Analyses ◽  
Group B ◽  
Biochemical Indices

Diabetes mellitus (DM) and hypertension usually co-exist, and when this happens, the prognosis would be worse than each disease alone. Given this, we evaluated the possible effects of valsartan and amlodipine administration on metformin-treated diabetic rats models induced by streptozotocin. Male Wistar rats (200–350 g) were fasted overnight. Then, we induced DM by administrating a single dose of 40 mg/kg streptozotocin (IP), which was confirmed after 48 h. Animals with blood sugar ≥ 200 mg/dl were considered diabetic and divided into four diabetic groups of untreated diabetic animals (Group B), diabetic animals treated with metformin (Group C), diabetic animals treated with metformin plus amlodipine (Group D), and diabetic rats treated with metformin plus valsartan (Group E). There was also a group A, consisting of normal rats with no drug treatment. After six weeks of treatment, we sacrificed the animals under chloroform anesthesia, and their blood samples were collected for hematological and biochemical analyses. The mortality rate in untreated diabetic rats was 100% before 6 weeks, but anti-diabetic treatment (metformin) significantly (P < 0.05) improved the survival rate and controlled their blood glucose level. The addition of antihypertensive drugs (amlodipine and valsartan) enhanced this curative effect. The various treated groups showed ameliorations in pathologic changes and biochemical indices, as well as, evidence of organ protection, compared with the untreated diabetic group. The study showed that adding an antihypertensive drug (amlodipine or valsartan) to metformin regimen improved outcomes in diabetic rats compared to using metformin alone.

L‐alanine supplementation improves blood glucose level and biochemical indices in alloxan‐induced diabetic rats

2020 ◽  
Author(s):  
Shamsudeen Umar Dandare ◽  
Ifeanyi Jude Ezeonwumelu ◽  
Tijjani Salihu Shinkafi ◽  
Umar Faruk Magaji ◽  
Abdulbaki Alfa‐Ibrahim Adio ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Biochemical Indices

scholarly journals Comparative Study of the Effects of Annona muricata and Tapinanthus globiferus Extracts on Biochemical Indices of Diabetic Rats

2019 ◽  
Vol 11 (6) ◽  
pp. 1365-1370 ◽  
Author(s):  
Atanu Atanu FO ◽  
Avwioroko Avwioroko OJ ◽  
Ilesanmi Ilesanmi OB ◽  
Oguche M Oguche M
Keyword(s):  
Comparative Study ◽  
Diabetic Rats ◽  
Annona Muricata ◽  
Biochemical Indices

scholarly journals Antidiabetic and anti-oxidant activities of the methanol leaf extract of Vernonia amygdalina in alloxan-induced diabetes in Wistar rats

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Adegbolagun T. Adeoye ◽  
Ademola A. Oyagbemi ◽  
Aduragbenro D. Adedapo ◽  
Temidayo O. Omobowale ◽  
Abiodun E. Ayodele ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Vernonia Amygdalina ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Biochemical Indices

The methanolic leaf extract of Vernonia amygdalina (MLVA) was assessed to evaluate its antidiabetic potential in rats. Diabetes was induced in male Wistar rats by the administration of alloxan monohydrate at 100 mg/kg of body weight. After 48 h, rats with fasting blood glucose levels of 200 mg/dL and above were considered diabetic and used for the study. The experimental animals were grouped into five groups (A–E) of 10 animals each. Group A rats were non-diabetic normal control, Group B consisted of diabetic control rats that received no treatment, groups C, D and E rats were diabetic rats but treated with glibenclamide, 200 and 400 mg/kg doses of MLVA respectively. Blood samples were collected at days 14 and 28 after induction for haematological and serum biochemical indices such as triglycerides, LDL, cholesterols etc. The intestine was collected and intestinal homogenate was prepared for the antioxidant studies. The extract at 200 mg/kg and 400 mg/kg doses significantly (p < 0.05) reduced blood glucose levels in extract-treated diabetic rats and also significantly increased weight gain in these rats. Most haematological parameters in treated rats experienced, while platelets and neutrophils were decreased. Biochemical indices measured were reduced in MLVA-treated groups compared with diabetic control. Treatment with MLVA also produced significant (p < 0.05) decrease in markers of oxidative stress but increased levels of enzymic and non-enzymic antioxidant markers in intestinal homogenates of treated groups compared with diabetic control. This study showed that V. amygdalina has antihyperglycaemic and in vivo antioxidant effects.

scholarly journals Amelioration of Diabetes-Induced Nephropathy by Loranthus regularis: Implication of Oxidative Stress, Inflammation and Hyperlipidaemia

2021 ◽  
Vol 11 (10) ◽  
pp. 4548
Author(s):  
Ahmed Z. Alanazi ◽  
Mohamed Mohany ◽  
Fawaz Alasmari ◽  
Ramzi A. A. Mothana ◽  
Abdulaziz O. A. Alshehri ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Tissue ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Glucose Levels ◽  
Renal Markers ◽  
Male Wistar Rats ◽  
Biochemical Indices ◽  
Elevated Lipid

In traditional Yemeni medicine, various preparations of Loranthus regularis (L. regularis), such as powder, decoctions and infusions are commonly used to treat diabetes, kidney stone formations and inflammation. In the present study, we evaluated the antinephrotoxic effects of L. regularis extract in experimentally-induced diabetes in male Wistar rats. A single dose (60 mg/kg/day) of Streptozotocin (STZ) was used to induce type 1 diabetes. Animals were then treated for four weeks with L. regularis extract (150 or 300 mg/kg/day) by oral gavage. Renal and blood samples were subsequently harvested. Several biochemical indices, oxidative stress and inflammatory markers were assessed. Additionally, histological alterations in the renal tissue were examined. Serum glucose levels were significantly (p < 0.01) lowered while insulin levels were enhanced in L. regularis-treated diabetic animals. The increased renal markers in diabetic rats were decreased by L. regularis treatment. Serum elevated lipid profiles were markedly decreased by the plant extract. The serum and renal cytokines that were significantly increased (p < 0.001) by STZ were diminished by L. regularis treatment. Finally, renal tissue antioxidant enzymatic activity was enhanced with L. regularis treatment. Taken together, the data here indicate that L. regularis possesses therapeutic ability to reduce the development of diabetic nephropathy (DN) by minimizing oxidative injury and inflammation.

scholarly journals Silver Nanoparticles Conjugate Attenuates Highly Active Antiretroviral Therapy-Induced Hippocampal Nissl Substance and Cognitive Deficits in Diabetic Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Sodiq Kolawole Lawal ◽  
Samuel Oluwaseun Olojede ◽  
Ayobami Dare ◽  
Oluwaseun Samuel Faborode ◽  
Edwin Coleridge S. Naidu ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Blood Glucose ◽  
Antiretroviral Therapy ◽  
Spatial Learning ◽  
Highly Active Antiretroviral Therapy ◽  
Systemic Exposure ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Highly Active ◽  
Biochemical Indices

Background. The application of nanomedicine to antiretroviral drug delivery holds promise in reducing the comorbidities related to long-term systemic exposure to highly active antiretroviral therapy (HAART). However, the safety of drugs loaded with silver nanoparticles has been debatable. This study is aimed at evaluating the effects of HAART-loaded silver nanoparticles (HAART-AgNPs) on the behavioural assessment, biochemical indices, morphological, and morphometric of the hippocampus in diabetic Sprague-Dawley rats. Methods. Conjugated HAART-AgNPs were characterized using FTIR spectroscopy, UV spectrophotometer, HR-TEM, SEM, and EDX for absorbance peaks, size and morphology, and elemental components. Forty-eight male SD rats ( 250 ± 13  g) were divided into nondiabetic and diabetic groups. Each group was subdivided into ( n = 8 ) A (nondiabetic+vehicle), B (nondiabetic+HAART), C (nondiabetic+HAART-AgNPs), D (diabetic+vehicle), E (diabetic+HAART), and F (diabetic+HAART-AgNPs). Morris water maze, Y-maze test, and weekly blood glucose levels were carried out. Following the last dose of 8-week treatment, the rats were anaesthetized and euthanized. Brain tissues were carefully removed and postfixed for Nissl staining histology. Results. 1.5 M concentration of HAART-AgNPs showed nanoparticle size 20.3 nm with spherical shape. HAART-AgNPs revealed 16.89% of silver and other elemental components of HAART. The diabetic control rats showed a significant increase in blood glucose, reduced spatial learning, positive hippocampal Nissl-stained cells, and a significant decrease in GSH and SOD levels. However, administration of HAART-AgNPs to diabetic rats significantly reduced blood glucose level, improved spatial learning, biochemical indices, and enhanced memory compared to diabetic control. Interestingly, diabetic HAART-AgNP-treated rats showed a significantly improved memory, increased GSH, SOD, and number of positive Nissl-stained neurons compared to diabetic-treated HAART only. Conclusion. Administration of HAART to diabetic rats aggravates the complications of diabetes and promotes neurotoxic effects on the experimental rats, while HAART-loaded silver nanoparticle (HAART-AgNP) alleviates diabetes-induced neurotoxicity.

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