scholarly journals Vitamin D Supplementation Reduces Serum Chemerin Level in Gestational Diabetes Mellitus Rat Model

2019 ◽  
Vol 87 (9) ◽  
pp. 3069-3080
Author(s):  
SUZAN M.M. MOURSI, M.D.; ABEER A. SAID, M.D.
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Rat Model ◽  
Vitamin D Supplementation

scholarly journals The Role of Vitamin D in the Development of Diabetes Post Gestational Diabetes Mellitus: A Systematic Literature Review

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1733
Author(s):  
Amélie Keller ◽  
Carmen Varela Vazquez ◽  
Rojina Dangol ◽  
Peter Damm ◽  
Berit Lilienthal Heitmann ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Literature Review ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Systematic Literature Review ◽  
Observational Studies ◽  
Vitamin D Supplementation ◽  
Diabetes Development ◽  
High Degree

Women diagnosed with gestational diabetes mellitus (GDM) are more likely to later develop diabetes. Evidence from some previous reviews suggests that low vitamin D status during pregnancy increases the risk of developing GDM, but whether vitamin D during pregnancy also influences the risk of diabetes post GDM is less well studied. Thus, the aim of this systematic literature review was to summarize the current available literature on that topic. This review considered observational studies and randomized controlled trials (RCTs). Five databases were searched. The risk of bias of the included studies was assessed. A total of six studies were included: three observational studies and three RCTs. Findings were inconsistent across the six included studies. However, when considering RCTs only, the findings more strongly suggested that vitamin D supplementation during and after pregnancy did not have an influence on markers of diabetes development or diabetes development post GDM. This systematic review highlights inconsistent findings on the associations between vitamin D supplementation or concentration during and after pregnancy and markers of diabetes development or diabetes development post GDM; and although results from randomized interventional studies more strongly suggested no associations, the conclusion holds a high degree of uncertainty.

scholarly journals Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0213006 ◽  
Author(s):  
Meline Rossetto Kron Rodrigues ◽  
Silvana Andréa Molina Lima ◽  
Glaucia Maria Ferreira da Silvia Mazeto ◽  
Iracema Mattos Paranhos Calderon ◽  
Claudia Garcia Magalhães ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Randomized Trials ◽  
Meta Analysis ◽  
Vitamin D Supplementation

scholarly journals Supplementation of Vitamin D in the Postdelivery Period of Women with Previous Gestational Diabetes Mellitus: Systematic Review and Meta-Analysis of Randomized Trials

2021 ◽  
Vol 43 (09) ◽  
pp. 699-709
Author(s):  
Meline Rossetto Kron-Rodrigues ◽  
Marilza Vieira Cunha Rudge ◽  
Silvana Andrea Molina Lima
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Postpartum Period ◽  
Vitamin D Supplementation ◽  
Model Assessment ◽  
Previous Gestational Diabetes Mellitus ◽  
Previous Gestational Diabetes

Abstract Objective To evaluate the effects of vitamin D supplementation in the postpartum period of women with previous gestational diabetes mellitus (GDM). Methods Randomized clinical trials of pregnant women with GDM of any chronological, gestational age and parity, with no history of previous disease who received vitamin D supplementation in the prenatal and/or postpartum period and were evaluated in the postpartum period were included. The PubMed, EMBASE, Cochrane, and LILACS databases were consulted until July 2019. Serum vitamin D concentration (25-hydroxyvitamin D in nmol/L), fasting blood glucose, glycated hemoglobin, serum calcium concentration, homeostatic model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), parathyroid hormone (PTH) and body mass index (BMI) were evaluated. Similar results in at least two trials were plotted using the RevMan 5; Cochrane Collaboration, Oxford, Reino Unido. The quality of the evidence was generated according to the classification, development, and evaluation of the classification of the recommendations. Results Four studies were included in the present review (200 women). The findings indicate that there is no difference in the postpartum period in women diagnosed with previous GDM who received vitamin D supplementation in the prenatal and/or in the postpartum period, showing only that there was a significant increase in the concentration of vitamin D (relative risk [RR]: 1.85; 95% confidence interval [CI]: 1.02–2.68). Conclusion This increase in the concentration of vitamin D should be interpreted with caution, since the assessment of the quality of the evidence was very low. For the other analyzed outcomes, there was no significance between the intervention and control groups, and the outcomes, when analyzed in their strength of evidence, were considered very low and low in their evaluation.

scholarly journals Effects of Nutritional Strategies on Glucose Homeostasis in Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Shixiao Jin ◽  
Liyan Sha ◽  
Jianli Dong ◽  
Jing Yi ◽  
Yang Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Serum Insulin ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Omega 3 ◽  
Magnesium Supplementation ◽  
Nutritional Strategies

Background. Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy, and nutritional therapy is the basis of GDM treatment. However, the effects of different forms of nutritional supplementation on improving gestational diabetes are uncertain. Objective. We conducted a network meta-analysis to evaluate the effects of supplementation with different nutrients on glucose metabolism in women with GDM. Methods. We conducted a literature search using PubMed, EMBASE, and the Cochrane Library to identify randomized controlled trials (RCTs) comparing the differences between different nutritional strategies in women with GDM. The Cochrane tool was used to assess the risk of bias. Pairwise meta-analysis and network meta-analysis were used to compare and rank the effects of nutritional strategies for the improvement of fasting plasma glucose (FPG), serum insulin, and homeostasis model assessment-insulin resistance (HOMA-IR). Results. We included thirteen RCTs with a total of 754 participants. Compared with placebo, omega-3, magnesium, vitamin D, zinc, and probiotics were more beneficial for improving FPG, serum insulin, and HOMA-IR. Network analysis showed that vitamin D supplementation was superior to omega-3 (-3.64 mg/dL, 95% CI: -5.77 to -1.51), zinc (-5.71 mg/dL, 95% CI: -10.19 to -1.23), probiotics (-6.76 mg/dL, 95% CI: -10.02 to -3.50), and placebo (-12.13 mg/dL, 95% CI: -14.55 to -9.70) for improving FPG. Magnesium supplementation was more beneficial for decreasing serum insulin compared with probiotics (-5.10 μIU/mL, 95% CI: -9.32 to -0.88) and placebo (-7.80 μIU/mL; 95% CI-11.95, -3.65). Vitamin D was more effective than probiotics (-0.99, 95% CI: -1.84 to -0.14) and placebo (-1.80, 95% CI: -2.45 to -1.16) for improving HOMA-IR. Conclusion. Vitamin D supplementation significantly reduced FPG and regulated HOMA-IR. Magnesium supplementation was superior in decreasing serum insulin than supplementation with other nutrients. Nutrient supplementation seemed to have an effect on glucose homeostasis maintenance in patients with GDM and may be considered an adjunctive therapy.

scholarly journals Maternal and Neonatal Metabolic Outcomes of Vitamin D Supplementation in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 73 (2) ◽  
pp. 145-159 ◽  
Author(s):  
Fatemeh Jahanjoo ◽  
Azizeh Farshbaf-Khalili ◽  
Seyed Kazem Shakouri ◽  
Neda Dolatkhah
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Vitamin D Supplementation ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Hs Crp

Introduction: Many scientists have revealed the association between vitamin D deficiency and gestational diabetes mellitus (GDM). The purpose of this review was to evaluate the impact of vitamin D supplementation on maternal and neonatal health measures in GDM. Methods: A comprehensive systematic literature search in the electronic databases including Cochrane Central Register of Controlled Trials, MEDLINE (PubMed), Scopus, Web of Sciences, EMBASE, Google Scholar, Clininaltrial.gov, and ProQuest as well as SID, Magiran, Irandoc, and Iranmedex for Persian literature review carried out up to January 2018. All RCTs and quasi-experimental studies that compared vitamin D supplementation with placebo or without supplementation on GDM women were included in this review. Results: Five randomized controlled trials involving 310 women were included in the meta-analysis. There were significant differences in fasting Plasma Glucose (FPG; mean difference [MD] –12.54, 95% CI –15.03 to –10.05; 3 trials, 223 participants); total cholesterol (TC; MD –24.77, 95% CI –32.57 to –16.98; 3 trials, 223 participants); low-density lipoprotein (LDL) cholesterol (MD –18.92, 95% CI –24.97 to –12.88; 3 trials, 223 participants); high-density lipoprotein (HDL) cholesterol (MD, 3.87, 95% CI 1.20–6.55; 3 trials, 223 participants); high sensitivity C-reactive protein ­(hs-CRP; MD –1.35, 95% CI –2.41 to –0.28; 2 trials, 126 participants); and Newborns’ hyperbilirubinemia (OR 0.33, 95% CI 0.13–0.80; 2 trials, 129 participants). Conclusions: Supplementation of GDM women with vitamin D may lead to an improvement in FPG, TC, LDL, HDL, hs-CRP serum levels as well as in newborns’ hyperbilirubinemia.

scholarly journals Impact of missingness on clinical trials on the effectiveness of antenatal vitamin D supplementation in gestational diabetes mellitus patients

2020 ◽  
Vol 3 (1) ◽  
pp. 138-139
Author(s):  
Sumanta Saha
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Clinical Trials ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Medical Complication ◽  
Maternal And Neonatal Outcomes ◽  
Cautious Interpretation

Gestational diabetes mellitus (GDM) is a vital medical complication of pregnancy in which glucose intolerance is first detected or develops during gestation. GDM is associated with adverse maternal and neonatal outcomes, and contemporarily, several clinical trials have tested their incidence in antenatal vitamin D receiving GDM patients. Considering their clinical significance, these trials' findings pertaining to the above outcomes require cautious interpretation, in terms of the risk of bias due to missingness. Any such bias in randomized controlled trials (RCT) can contaminate the results of a meta-analysis that extracts data from these RCTs.

Sign in / Sign up

Export Citation Format

Share Document