scholarly journals SIRS Score Reflects Clinical Features of Non-Acetaminophen-Related Acute Liver Failure with Hepatic Coma

2012 ◽  
Vol 51 (8) ◽  
pp. 823-828 ◽  
Author(s):  
Yasuhiro Miyake ◽  
Tetsuya Yasunaka ◽  
Fusao Ikeda ◽  
Akinobu Takaki ◽  
Kazuhiro Nouso ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Clinical Features ◽  
Hepatic Coma

A STUDY ON ETIOLOGY, CLINICAL FEATURES, MANAGEMENT AND OUTCOME OF ACUTE LIVER FAILURE IN PAEDIATRIC INTENSIVE CARE UNIT OF BURDWAN MEDICAL COLLEGE

2021 ◽  
pp. 54-55
Author(s):  
Sankar narayan mishra ◽  
Kaustav nayek ◽  
Tamal kayal ◽  
Debarshi Jana
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Pediatric Intensive Care Unit ◽  
Clinical Features ◽  
Paediatric Intensive Care Unit ◽  
Pediatric Intensive Care ◽  
Medical College ◽  
Bacterial Peritonitis

Introduction: In the present study, etiology, important clinical features, management and outcome of acute liver failure in children admitted in Pediatric Intensive Care Unit (PICU) of BURDWAN MEDICALCOLLEGE, WB are studied. Aims and objectives:To study different clinical features among those children having acute liver failure. I. To study the management and outcome of those children with acute liver failure in the Pediatric Intensive Care Unit. Material and methods: Pediatric Intensive Care Unit of BURDWAN MEDICALCOLLEGE, WB. 1 Year [December 2019 to November 2020]. Patients from 3months of age to 12years of age are eligible for enrolment if they meet the following criteria. Conclusion: Present study showed that cerebral edema was signicantly associated with mortality whereas AKI and spontaneous bacterial peritonitis were not signicantly related with mortality. Mean TSB and Prothrobin Time were higher but mean serum albumin was lower in those cases that had died.

scholarly journals Clinical features, laboratory characteristics and outcome of patients with drug-induced acute liver failure

2019 ◽  
Vol 6 (2) ◽  
pp. 515
Author(s):  
Tauseef Nabi ◽  
Nadeema Rafiq ◽  
Imran Jamil ◽  
Quratul Ain Arifa
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Hospital Stay ◽  
Clinical Features ◽  
Geographical Area ◽  
Length Of Hospital Stay ◽  
Medical Emergency ◽  
Rapid Progression ◽  
Middle Aged ◽  
Drug Induced

Background: Acute liver failure (ALF) is a rare medical emergency. Its rapid progression and high mortality demand early diagnosis and expert management. Drug-induced ALF (DI-ALF) remains the uncommon cause of ALF in India. Clinical and etiological profile varies with geographical area and time. A prospective study of DI-ALF was carried with the aim to determine the clinical features, laboratory characteristics, outcome and hospital course.Methods: A total of 15 patients with a diagnosis of DI-ALF were included in the study. The variables evaluated were demographic, signs and symptoms, biochemical parameters [bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), prothrombin time (PT), internal normalization ratio (INR) etc.], outcome and course during hospitalization.Results: Out of 15 DI-ALF patients, 12 had Anti-tuberculosis therapy (ATT) induced ALF and 3 patients had ayurvedic induced ALF. Majority of the patients were females (73.3%) and middle-aged (42.60±14.30 years). Coma grade at the time of admission showed that majority of patients (66.8%) had grade I and II encephalopathy. Depending on the pattern of liver injury, hepatocellular pattern was most common (53.3%) followed by mixed and cholestatic pattern. 40% of patients died with DI-ALF complications of which ATT induced ALF contributed 41.7%. Mean AST was more increased as compared to ALT. Development of ascites (P = 0.030) and mannitol use (P = 0.025) was significantly more common in non survived group than survived group. Length of hospital stay was significantly more in non survived group than survived group (P = 0.009).Conclusions: ATT was the class of drugs most frequently associated with DI-ALF. DI-ALF disproportionately affected middle-aged women. Most DILI ALF patients had hepatocellular injury pattern. 40% of patients died with DI-ALF complications. Development of ascites, mannitol use and length of hospital stay was significantly more in non survived group than survived group.

229 A Prospective Study of Acute Liver Failure Due to Hepatic Ischemia: Clinical Features and Outcomes

2008 ◽  
Vol 134 (4) ◽  
pp. A-759 ◽  
Author(s):  
Kartikkumar Jinjuvadia ◽  
Ryan M. Taylor ◽  
Robert J. Fontana ◽  
Timothy J. Davern ◽  
Obaid S. Shaikh ◽  
...  
Keyword(s):  
Liver Failure ◽  
Prospective Study ◽  
Acute Liver Failure ◽  
Clinical Features ◽  
Hepatic Ischemia ◽  
A Prospective Study

Acute liver failure due to zinc phosphide containing rodenticide poisoning: Clinical features and prognostic indicators of need for liver transplantation

2015 ◽  
Vol 34 (4) ◽  
pp. 325-329 ◽  
Author(s):  
Vivek Saraf ◽  
Supriya Pande ◽  
Unnikrishnan Gopalakrishnan ◽  
Dinesh Balakrishnan ◽  
Ramachandran N. Menon ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Clinical Features ◽  
Zinc Phosphide ◽  
Prognostic Indicators

Plasmapheresis in Acute Liver Failure

1986 ◽  
Vol 9 (6) ◽  
pp. 433-438 ◽  
Author(s):  
J.G. Freeman ◽  
K. Matthewson ◽  
C.O. Record
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatic Failure ◽  
Serum Bilirubin ◽  
Hepatic Coma ◽  
Acute Hepatic Failure ◽  
Plasma Ammonia ◽  
Coma Grade ◽  
Better Than

A series of 9 patients with acute hepatic failure and Grade IV hepatic coma received daily plasmapheresis until they recovered or death ensued. Of the nine, seven (77%) showed an improvement in coma grade and five (55%) survived to leave hospital. Plasmapheresis significantly decreased serum bilirubin, asparate aminotransferase and plasma ammonia concentrations. Survival following plasmapheresis appeared substantially better than in a non randomized group of similar patients not plasmapheresed. The simplicity of the procedure, biochemical improvements observed and apparent efficacy, suggest that further evaluation of the technique as a means of providing temporary hepatic support is indicated.

scholarly journals Insights into the management of Wilson’s disease

2017 ◽  
Vol 10 (11) ◽  
pp. 889-905 ◽  
Author(s):  
Mohmadshakil Kathawala ◽  
Gideon M. Hirschfield
Keyword(s):  
Liver Disease ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Clinical Features ◽  
Wilson’S Disease ◽  
Early Recognition ◽  
Clinical Signs ◽  
Wilson's Disease ◽  
Biochemical Tests ◽  
Causative Gene

Wilson’s disease is a rare, inherited autosomal recessive disease of copper metabolism, in which the causative gene, ATP7B, results in absent or reduced function of the ATP7B transporter important for biliary excretion of copper and incorporation of copper into caeruloplasmin. Affected patients accumulate excessive copper within the liver, brain and other tissues. A disease mainly of children, adolescents and young adults; clinical features vary from the asymptomatic state to chronic liver disease, acute liver failure, and neuropsychiatric manifestations. Diagnosis requires a high index of suspicion and is based on a combination of clinical signs, biochemical tests, hepatic copper content assay and mutation analysis of the ATP7B gene; to date, there are more than 500 mutations of ATP7B in patients with Wilson’s disease. Early recognition and treatment can result in an excellent prognosis whereas untreated disease is almost always fatal. Drug therapies include chelating agents, such as penicillamine or trientine, and zinc salts. Liver transplantation is curative correcting the underlying pathophysiology and is traditionally indicated in acute liver failure or end-stage liver disease refractory to medical therapy. This review provides an overview of various aspects of Wilson’s disease including molecular basis of the disease, clinical features, diagnostic and management strategies with their current limitations.

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