scholarly journals Clinical Studies as Professionals : Guidelines and Clinical Practice Qualitative and Quantitive Study.

2010 ◽  
Vol 99 (10) ◽  
pp. 2610-2617
Author(s):  
Osamu Takahashi
Keyword(s):  
Clinical Practice ◽  
Clinical Studies

scholarly journals Mitogen Activated Protein Kinases in Steatotic and Non-Steatotic Livers Submitted to Ischemia-Reperfusion

2019 ◽  
Vol 20 (7) ◽  
pp. 1785 ◽  
Author(s):  
Jiménez-Castro ◽  
Cornide-Petronio ◽  
Gracia-Sancho ◽  
Casillas-Ramírez ◽  
Peralta
Keyword(s):  
Risk Factor ◽  
Clinical Practice ◽  
Protein Kinases ◽  
Hepatic Steatosis ◽  
Ischemic Preconditioning ◽  
Liver Surgery ◽  
Clinical Studies ◽  
Ischemia Reperfusion ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein

: We analyzed the participation of mitogen-activated protein kinases (MAPKs), namely p38, JNK and ERK 1/2 in steatotic and non-steatotic livers undergoing ischemia-reperfusion (I-R), an unresolved problem in clinical practice. Hepatic steatosis is a major risk factor in liver surgery because these types of liver tolerate poorly to I-R injury. Also, a further increase in the prevalence of steatosis in liver surgery is to be expected. The possible therapies based on MAPK regulation aimed at reducing hepatic I-R injury will be discussed. Moreover, we reviewed the relevance of MAPK in ischemic preconditioning (PC) and evaluated whether MAPK regulators could mimic its benefits. Clinical studies indicated that this surgical strategy could be appropriate for liver surgery in both steatotic and non-steatotic livers undergoing I-R. The data presented herein suggest that further investigations are required to elucidate more extensively the mechanisms by which these kinases work in hepatic I-R. Also, further researchers based in the development of drugs that regulate MAPKs selectively are required before such approaches can be translated into clinical liver surgery.

Users of biologics in clinical practice: would they be eligible for phase III clinical studies? Cohort Study in the French Psoriasis Registry PSOBIOTEQ

2019 ◽  
Vol 34 (2) ◽  
pp. 293-300 ◽  
Author(s):  
M. Masson Regnault ◽  
J. Castañeda‐Sanabria ◽  
M.H.T. Diep Tran ◽  
M. Beylot‐Barry ◽  
H. Bachelez ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clinical Practice ◽  
Clinical Studies ◽  
Phase Iii

scholarly journals MODERN METHODS OF GREAT OBSTETRICAL SYNDROMES PROGNOSTICATION (LITERATURE REVIEW)

2019 ◽  
Vol 72 (4) ◽  
pp. 704-706
Author(s):  
Natalia Y. Lemish
Keyword(s):  
Clinical Practice ◽  
Literature Review ◽  
Clinical Studies ◽  
Negative Consequences ◽  
Early Correction ◽  
Modern Methods ◽  
History Of ◽  
Laboratory Investigations

Introduction: The term “Great Obstetrical Syndromes” (GOS) was widely implemented to clinical practice after 2009, due to publications of G. C. Di Renzo and R. Romero. The effective prognostical methods are still being searched for early correction of the disorders and decrease of negative consequences on mother and fetus. The aim: To analyze the up to date data concerning prognostication of Great obstetrical syndromes. Materials and methods: Used database Pubmed from 2004 up till 2019 to search clinical studies of great obstetrical syndromes. Conclusions: The literature review summarizes the data about existing methods of prognostication of GOS based on history of the patient and the results of additional clinical and laboratory investigations.

scholarly journals Biological enhancement of graft-tunnel healing in anterior cruciate ligament reconstruction

Joints ◽  
2016 ◽  
Vol 04 (03) ◽  
pp. 174-182
Author(s):  
Maristella Saccomanno ◽  
Luigi Capasso ◽  
Luca Fresta ◽  
Giuseppe Milano
Keyword(s):  
Anterior Cruciate Ligament ◽  
Clinical Practice ◽  
Clinical Studies ◽  
Cruciate Ligament ◽  
Healing Process ◽  
Bone Tunnel ◽  
Therapeutic Effects ◽  
Tunnel Length ◽  
Acl Graft ◽  
Anterior Cruciate

The sites where graft healing occurs within the bone tunnel and where the intra-articular ligamentization process takes place are the two most important sites of biological incorporation after anterior cruciate ligament (ACL) reconstruction, since they help to determine the mechanical behavior of the femur-ACL graft-tibia complex. Graft-tunnel healing is a complex process influenced by several factors, such as type of graft, preservation of remnants, bone quality, tunnel length and placement, fixation techniques and mechanical stress. in recent years, numerous experimental and clinical studies have been carried out to evaluate potential strategies designed to enhance and optimize the biological environment of the graft-tunnel interface.Modulation of inflammation, tissue engineering and gene transfer techniques have been applied in order to obtain a direct-type fibrocartilaginous insertion of the ACL graft, similar to that of native ligament, and to accelerate the healing process of tendon grafts within the bone tunnel. Although animal studies have given encouraging results, clinical studies are lacking and their results do not really support the use of the various strategies in clinical practice. Further investigations are therefore needed to optimize delivery techniques, therapeutic concentrations, maintenance of therapeutic effects over time, and to reduce the risk of undesirable effects in clinical practice.

scholarly journals Scar Symptoms: Pruritus and Pain

2020 ◽  
pp. 87-101
Author(s):  
Osama Farrukh ◽  
Ioannis Goutos
Keyword(s):  
Quality Of Life ◽  
Wound Healing ◽  
Clinical Practice ◽  
Clinical Studies ◽  
Scar Formation ◽  
Keloid Scars ◽  
Sensory Modalities ◽  
Sensory Disturbances ◽  
Key Features

AbstractScars can present with a wide variety of symptoms relating to appearance, function, as well as sensory disturbances. Pain and pruritus (itch) are by far the most common symptoms in clinical practice; they are often severe and have the propensity to persist over a prolonged period of time following wound healing. Earlier notions supported itch as a sub-modality of pain; however, with recent advances in the pathophysiology field and the delineation of discrete neurological pathways, they are recognized to comprise separate sensory modalities albeit sharing common key features. There is a significant amount of evidence that sensory symptoms can decrease patients’ quality of life in the acute and rehabilitative phase of wound healing and scar formation. This chapter aims to outline the basic pathophysiological processes underlying pain and pruritus in scars and present a variety of options available for management of these symptoms. The section will primarily draws upon scientific and clinical studies relating to burn hypertrophic and keloid scars given that most literature reports have studied sensory disturbances in these subtypes.

scholarly journals CLINICAL STUDIES ON LEARNING DISORDER IN AYURVEDA - A REVIEW

2021 ◽  
Vol p5 (02) ◽  
pp. 2733-2739
Author(s):  
Subina T. K ◽  
Satheesh K
Keyword(s):  
Academic Achievement ◽  
Clinical Practice ◽  
Social Adjustment ◽  
Learning Process ◽  
Clinical Studies ◽  
Growth And Development ◽  
Learning Disorders ◽  
Learning Disorder ◽  
Linguistic Processing ◽  
Developmental Skills

Learning disorders are defined as problems in securing of developmental skills, academic achievement, social adjustment and secondarily emotional growth and development as a consequence of perceptual and linguistic processing deficits. The prevalence of learning disorders is 15.17 % in Southern India. In ayurvedic classics no separate narrative of such disease is seen, but many times delayed developmental skills such as Vāksḳalanam, alpamedha-smṛti etc. are stated and different remedies are considered for them. The Indriyās (sense faculties), Manas (mind), Buddhi (intellect) are comprised in the process of Jñānotpatti. Any altered function in these components hampers the learning process. Even if several studies have been conducted in Ayurveda on Learning disorder, the area remains still non conclusive. This is an attempt to report the studies from the postgraduate institute for Ayurveda psychiatry, with the available conclusions so as to augment the accessible possibilities in the clinical practice.

Philosophical Perspectives on Medicine and Religion

2017 ◽  
Author(s):  
James A. Marcum
Keyword(s):  
Clinical Trials ◽  
Clinical Practice ◽  
Clinical Outcomes ◽  
Clinical Studies ◽  
Ethical Issues ◽  
Human Suffering ◽  
Philosophical Issue ◽  
Research And Practice ◽  
Spirituality And Religion

In this chapter, I survey the literature concerning selected metaphysical, epistemological, and ethical issues surrounding the intersection of spirituality and religion with medicine. The metaphysical issues concern what constitutes spirituality and its distinction from religion, especially with respect to medical research and practice; the nature of the causal relationship, particularly in mechanistic terms, between spirituality and clinical outcomes; and, the presuppositions animating clinical studies. The epistemological issues pertain to empirical evidence from clinical trials. The main issue is whether the evidence from these trials justifies an impact of spirituality and religion on health and clinical outcomes. The ethical issues involve how best to incorporate spirituality and religion into clinical practice, if they should be incorporated at all. Finally, the fundamental philosophical issue addressed in this chapter is whether the intersection of spirituality and religion with medicine has led to a humanized medicine that achieves medicine’s primary goal of relieving or reducing human suffering associated with illness.

scholarly journals Modulating Metabolism to Improve Cancer-Induced Muscle Wasting

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Fabio Penna ◽  
Riccardo Ballarò ◽  
Marc Beltrá ◽  
Serena De Lucia ◽  
Paola Costelli
Keyword(s):  
Clinical Trials ◽  
Clinical Practice ◽  
Cancer Patients ◽  
Clinical Studies ◽  
Cancer Cachexia ◽  
Muscle Wasting ◽  
Muscle Metabolism ◽  
Preclinical Models ◽  
Oncologic Patients ◽  
Clinical Conditions

Muscle wasting is one of the main features of cancer cachexia, a multifactorial syndrome frequently occurring in oncologic patients. The onset of cachexia is associated with reduced tolerance and response to antineoplastic treatments, eventually leading to clinical conditions that are not compatible with survival. Among the mechanisms underlying cachexia, protein and energy dysmetabolism play a major role. In this regard, several potential treatments have been proposed, mainly on the basis of promising results obtained in preclinical models. However, at present, no treatment yet reached validation to be used in the clinical practice, although several drugs are currently tested in clinical trials for their ability to improve muscle metabolism in cancer patients. Along this line, the results obtained in both experimental and clinical studies clearly show that cachexia can be effectively approached by a multidirectional strategy targeting nutrition, inflammation, catabolism, and inactivity at the same time. In the present study, approaches aimed to modulate muscle metabolism in cachexia will be reviewed.

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