scholarly journals Renal resistivity index as an aid in the diagnosis of acute kidney injury in bitches with pyometra

2021 ◽  
Vol 15 (3) ◽  
pp. 225-228
Author(s):  
Aline de Sousa Alves ◽  
Fernanda Vieira Henrique ◽  
Sabrina Barros Araújo ◽  
Dayanny de Sousa Alencar ◽  
Higina Moreira Melo ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Small Animal ◽  
Kidney Injury ◽  
Urinary Protein ◽  
Creatinine Ratio ◽  
Resistivity Index ◽  
Gamma Glutamyltransferase ◽  
Early Markers ◽  
The Right

This study aimed to evaluate the renal function of six bitches of various breeds and ages, with open pyometra, attended in the Small Animal Medical Clinic sector of the Veterinary Hospital from Federal University of Campina Grande, through the measurement of laboratory tests: urea and creatinine serum, dosage of the urinary Protein-Creatinine Ratio (PCR), urinary gamma-glutamyltransferase (GGT) and determination of the renal resistivity index (RI). The levels of urea and creatinine were elevated in 16.6% (1/6) of the female dogs; the urinary protein-creatinine ratio was increased in 66.6% (4/6), while the urinary gamma-glutamyltransferase value was elevated in 50% (3/6). The renal resistivity index was increased in the right and left kidneys by 66.6% (4/6) of bitches, with no statistical difference between them. It was concluded that the renal resistivity index was a practical and effective method to assist in the diagnosis of acute kidney injury, along with other early markers, such as PCR and urinary GGT.

scholarly journals A comparison of observed versus estimated baseline creatinine for determination of RIFLE class in patients with acute kidney injury

2009 ◽  
Vol 24 (9) ◽  
pp. 2739-2744 ◽  
Author(s):  
S. M. Bagshaw ◽  
S. Uchino ◽  
D. Cruz ◽  
R. Bellomo ◽  
H. Morimatsu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Baseline Creatinine

Management of acute kidney injury and chronic kidney disease

2017 ◽  
pp. 1087-1096
Author(s):  
Natalie Ebert ◽  
Elke Schaeffner
Keyword(s):  
Older Adults ◽  
Chronic Kidney Disease ◽  
Acute Kidney Injury ◽  
Kidney Disease ◽  
Kidney Injury ◽  
Staging System ◽  
Kidney Damage ◽  
The Right ◽  
Stage Renal Disease ◽  
End Stage

Both acute and chronic states of kidney disease have considerable healthcare impact as they can produce enormous disease burden and costs. To classify chronic kidney disease into the CKD staging system, glomerular filtration rate as an index of kidney function, as well as albuminuria as a marker of kidney damage have to be assessed as correctly as possible. Misclassification is a serious concern due to the difficulties in precise GFR assessment and correct interpretation of results. Differentiating between pure senescence and true disease among older adults can be a delicate issue. To find the right renal replacement option for individuals that progress to end-stage renal disease can be challenging, and some older patients may even benefit from conservative care without dialysis. To prevent acute kidney injury as a frequent and potentially life-threatening complication, clinicians need to develop an understanding of the common vulnerability to kidney damage among older adults.

scholarly journals Protopine Protects Mice against LPS-Induced Acute Kidney Injury by Inhibiting Apoptosis and Inflammation via the TLR4 Signaling Pathway

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 15 ◽  
Author(s):  
Beibei Zhang ◽  
Mengnan Zeng ◽  
Meng Li ◽  
Yuxuan Kan ◽  
Benke Li ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Function ◽  
Signaling Pathway ◽  
Interleukin 2 ◽  
Small Animal ◽  
Kidney Injury ◽  
Interleukin 10 ◽  
Tlr4 Signaling ◽  
Tlr4 Signaling Pathway ◽  
Apoptosis And Inflammation

Corydalis humosa Migo is a traditional Chinese medicine that clears away damp heat, relieves sore. Protopine (PRO) is an alkaloid component isolated from C. humosa Migo. However, the role of protopine in acute kidney injury (AKI) has not yet been reported. This study aims to investigate the effect and mechanism of protopine isolated from C. humosa Migo on lipopolysaccharide (LPS)-induced AKI in mice. Inflammation accumulation was assessed by small animal living imaging. The blood urea nitrogen (BUN), and serum creatinine (Scr) were measured to assess the effects of protopine on renal function in LPS-induced AKI. The levels of tumor necrosis factor (TNF), interleukin-2 (IL-2), interferon-γ (IFN-γ), and (interleukin-10) IL-10 in serum were detected by cytometric bead array. Flow cytometry was used to detect the levels of reactive oxygen species (ROS) in primary kidney cells. The proportions of granulocytes, neutrophils, and macrophages in peripheral blood were examined to evaluate the effect of protopine on immune cells in mice with AKI. Toll-like receptor (TLR4) and apoptotic signaling pathway were detected by Western blot analysis. The results showed that protopine markedly improved the renal function, relieve inflammation, reversed inflammatory cytokines, transformed apoptosis markers, and regulated the TLR4 signaling pathway in mice with AKI induced by LPS. The protopine isolated from C. humosa Migo protected mice against LPS-induced AKI by inhibiting apoptosis and inflammation via the TLR4 signaling pathway, thus providing a molecular basis for a novel medical treatment of AKI.

scholarly journals Acute Kidney Injury Pharmacokinetic Changes and Its Impact on Drug Prescription

Healthcare ◽  
2019 ◽  
Vol 7 (1) ◽  
pp. 10 ◽  
Author(s):  
Victoria Blanco ◽  
Carolina Hernandorena ◽  
Paula Scibona ◽  
Waldo Belloso ◽  
Carlos Musso
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Function ◽  
Drug Prescription ◽  
Kidney Injury ◽  
Drug Dosage ◽  
Tubular Secretion ◽  
Metabolizing Enzymes ◽  
Drug Concentrations ◽  
The Impact

Acute kidney injury (AKI) is a common problem in hospitalized patients that is associated with significant morbid-mortality. The impact of kidney disease on the excretion of drugs eliminated by glomerular filtration and tubular secretion is well established, as well as the requirement for drug dosage adjustment in impaired kidney function patients. However, since impaired kidney function is associated with decreased activity of several hepatic and gastrointestinal drug-metabolizing enzymes and transporters, drugs doses adjustment only based on kidney alteration could be insufficient in AKI. In addition, there are significant pharmacokinetics changes in protein binding, serum amino acid levels, liver, kidney, and intestinal metabolism in AKI, thus the determination of plasma drug concentrations is a very useful tool for monitoring and dose adjustment in AKI patients. In conclusion, there are many pharmacokinetics changes that should be taken into account in order to perform appropriate drug prescriptions in AKI patients.

scholarly journals SP193CYSTATIN/CREATININE RATIO: A PROGNOSTIC MARKER AFTER ACUTE KIDNEY INJURY

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii168-iii169
Author(s):  
Sofia Correia ◽  
Andreia Campos ◽  
Jorge Malheiro ◽  
Josefina Santos ◽  
António Cabrita
Keyword(s):  
Acute Kidney Injury ◽  
Prognostic Marker ◽  
Kidney Injury ◽  
Creatinine Ratio

scholarly journals Serum symmetric dimethylarginine concentration in healthy horses and horses with acute kidney injury

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Natalia Siwinska ◽  
Agnieszka Zak ◽  
Malwina Slowikowska ◽  
Artur Niedzwiedz ◽  
Urszula Paslawska
Keyword(s):  
Acute Kidney Injury ◽  
Body Weight ◽  
Serum Creatinine ◽  
Healthy Adult ◽  
Small Animal ◽  
Kidney Injury ◽  
Blood Analysis ◽  
Advanced Degree ◽  
Kidney Dysfunction ◽  
Symmetric Dimethylarginine

Abstract Background There are limited options to diagnose acute kidney injury (AKI) in horses. Symmetric dimethylarginine (SDMA) is routinely used in human and small animal medicine. The aim of this study was to assess serum SDMA concentrations in healthy horses and horses with AKI. The objective of this study was to evaluate the association of: 1) age, 2) sex, 3) body weight and 4) serum creatinine and urea levels on serum SDMA concentrations. Fifty-three healthy horses, including 17 foals (2–6 months of age) and 36 adult horses (3–29 years of age), and 23 horses with AKI were included in the study based on history, physical examination, blood analysis, urinalysis and an ultrasonographic examination of the urinary tract. Serum SDMA concentrations were measured using a non-species specific commercial ELISA test. Results In healthy adult horses, the value of SDMA was 0.53 ± 0.14 μmol/L. The value was higher in foals (1.5 ± 0.4 μmol/L, P < 0.001). Horses with AKI had significantly higher concentrations of SDMA compared to healthy horses (1.76 ± 1.05 μmol/L, P < 0.001). In the healthy adult horses, there was no association of sex, age or body weight on SDMA. However, a significant positive relationship was found between serum creatinine and SDMA concentrations. Conclusions Healthy adult horses had SDMA values similar to those of other species. Foals had higher SDMA values. Therefore, different reference values should be created for them. The study confirmed an increased SDMA in horses with AKI. This, as well as the low influence of extrarenal factors on the SDMA values, may confirm its usefulness in the diagnosis of kidney dysfunction. Higher SDMA values may also indicate a more advanced degree of kidney dysfunction. Further research is required to determine whether SDMA could be used to detect kidney dysfunction in the asymptomatic stage of AKI.

scholarly journals Dickkopf-3 in the prediction of contrast media induced acute kidney injury

2020 ◽  
Author(s):  
Felix S. Seibert ◽  
Anja Heringhaus ◽  
Nikolaos Pagonas ◽  
Benjamin Rohn ◽  
Frederic Bauer ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Kidney Injury ◽  
Kidney Disease ◽  
Coronary Angiography ◽  
Predictive Accuracy ◽  
Area Under The Curve ◽  
Kidney Injury ◽  
Acute Kidney Injury Network ◽  
Creatinine Ratio ◽  
Creatinine Concentration

Abstract Background Dickkopf-3 (DKK3) has recently been discovered as a urinary biomarker for the prediction of acute kidney injury (AKI) after cardiac surgery. This finding needs to be confirmed for AKI in other clinical settings. The present study investigates whether DKK3 can predict contrast-induced AKI (CI-AKI). Methods We performed a prospective study in 490 patients undergoing coronary angiography. Primary endpoint was an increase in serum creatinine concentration ≥ 0.3 mg/dl within 72 h after the procedure. DKK3 was assessed < 24 h before coronary angiography. Predictive accuracy was assessed by receiver operating characteristic (ROC) curves. Results CI-AKI was observed in 30 (6.1%) patients, of whom 27 corresponded to stage I and 3 to stage II according to the Acute Kidney Injury Network (AKIN) criteria. Subjects who developed CI-AKI had a 3.8-fold higher urinary DKK3/creatinine ratio than those without CI-AKI (7.5 pg/mg [interquartile range [IQR] 1.2–1392.0] vs. 2.0 pg/mg [IQR 0.9–174.0]; p = 0.047). ROC analysis revealed an area under the curve (AUC) of 0.61. Among subjects without clinically overt chronic kidney disease (estimated glomerular filtration rate [eGFR] > 60 ml/min, urinary albumin creatinine ratio < 30 mg/g), the DKK3/creatinine ratio was 5.4-fold higher in those with subsequent CI-AKI (7.5 pg/mg [IQR 0.9–590.1] vs. 1.38 pg/mg [IQR 0.8–51.0]; p = 0.007; AUC 0.62). Coronary angiography was associated with a 43 times increase in the urinary DKK3/creatinine ratio. Conclusions Urinary DKK3 is an independent predictor of CI-AKI even in the absence of overt chronic kidney disease (CKD). The study thereby expands the findings on DKK3 in the prediction of postoperative loss of kidney function to other entities of AKI. Graphic abstract

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