Mitogen-activated Protein Kinase (MAPK) Interacting Kinases 1 and 2 (MNK1 and MNK2) as Targets for Cancer Therapy: Recent Progress in the Development of MNK Inhibitors

2017 ◽  
Vol 24 (28) ◽  
Author(s):  
Agnieszka Dreas ◽  
Maciej Mikulski ◽  
Mariusz Milik ◽  
Charles-Henry Fabritius ◽  
Krzysztof Brzózka ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Cancer Therapy ◽  
Recent Progress ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein

Roles of p38 MAPKs in invasion and metastasis

2012 ◽  
Vol 40 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Ivan del Barco Barrantes ◽  
Angel R. Nebreda
Keyword(s):  
Protein Kinase ◽  
P38 Mapk ◽  
Recent Progress ◽  
Mitogen Activated Protein Kinase ◽  
Surrounding Tissue ◽  
Activity Levels ◽  
Invasion And Metastasis ◽  
Mapk Activity ◽  
Mitogen Activated Protein ◽  
Protein Kinase Signalling

Cells from primary tumours need to go through several steps to become fully metastatic. During this process, cancer cells acquire the ability to invade, migrate across the surrounding tissue, enter into the circulation and colonize distant organs. In the present paper, we review recent progress in understanding how the p38 MAPK (mitogen-activated protein kinase) signalling pathway participates in the different steps of metastasis. Experimental evidence suggests that tumour cells need to modulate p38 MAPK activity levels to successfully metastasize.

scholarly journals In Silico Design of E3 Ubiquitin-Protein Ligase NEDD4-1 Inhibitors: An Alternative Approach for Targeting the MAPK Pathway in Cancer Therapy

Proceedings ◽  
2019 ◽  
Vol 22 (1) ◽  
pp. 10
Author(s):  
Pirolli ◽  
Righino ◽  
Tropea ◽  
Gurrieri ◽  
Sangiorgi ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Cancer Therapy ◽  
In Silico ◽  
Mapk Pathway ◽  
Mitogen Activated Protein Kinase ◽  
In Silico Design ◽  
Ubiquitin Protein Ligase ◽  
Alternative Approach ◽  
Mitogen Activated Protein ◽  
Kinase Pathway

Among all the several targets in common use in the antitumor therapies, the pharmacologicinhibition of the MAPK (Mitogen Activated Protein Kinase) pathway represents an efficienttherapeutic approach [1]. [...]

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