The Heat Stress Response and Diabetes: More Room for Mitochondrial Implication

AbstractHeat shock transcription factors (HSFs) are central elements in the regulatory network that controls plant heat stress response. They are involved in multiple transcriptional regulatory pathways and play important roles in heat stress signaling and responses to a variety of other stresses. We identified 41 members of the HSF gene family in moso bamboo, which were distributed non-uniformly across its 19 chromosomes. Phylogenetic analysis showed that the moso bamboo HSF genes could be divided into three major subfamilies; HSFs from the same subfamily shared relatively conserved gene structures and sequences and encoded similar amino acids. All HSF genes contained HSF signature domains. Subcellular localization prediction indicated that about 80% of the HSF proteins were located in the nucleus, consistent with the results of GO enrichment analysis. A large number of stress response–associated cis-regulatory elements were identified in the HSF upstream promoter sequences. Synteny analysis indicated that the HSFs in the moso bamboo genome had greater collinearity with those of rice and maize than with those of Arabidopsis and pepper. Numerous segmental duplicates were found in the moso bamboo HSF gene family. Transcriptome data indicated that the expression of a number of PeHsfs differed in response to exogenous gibberellin (GA) and naphthalene acetic acid (NAA). A number of HSF genes were highly expressed in the panicles and in young shoots, suggesting that they may have functions in reproductive growth and the early development of rapidly-growing shoots. This study provides fundamental information on members of the bamboo HSF gene family and lays a foundation for further study of their biological functions in the regulation of plant responses to adversity.

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Dynamic Responses to Acute Heat Stress between 34 °C and 38.5 °C, and Characteristics of Heat Stress Response in Mice

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.26.701 ◽

2003 ◽

Vol 26 (5) ◽

pp. 701-708 ◽

Cited By ~ 24

Author(s):

Naoki Harikai ◽

Kanji Tomogane ◽

Mitsue Miyamoto ◽

Keiko Shimada ◽

Satoshi Onodera ◽

...

Keyword(s):

Heat Stress ◽

Stress Response ◽

Dynamic Responses ◽

Heat Stress Response ◽

Acute Heat Stress

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The Transcriptional Cascade in the Heat Stress Response of Arabidopsis Is Strictly Regulated at the Level of Transcription Factor Expression

The Plant Cell ◽

10.1105/tpc.15.00435 ◽

2015 ◽

Vol 28 (1) ◽

pp. 181-201 ◽

Cited By ~ 57

Author(s):

Naohiko Ohama ◽

Kazuya Kusakabe ◽

Junya Mizoi ◽

Huimei Zhao ◽

Satoshi Kidokoro ◽

...

Keyword(s):

Transcription Factor ◽

Heat Stress ◽

Stress Response ◽

Heat Stress Response ◽

Factor Expression ◽

Transcription Factor Expression

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Polymorphisms in stress response genes in Lactobacillus plantarum: implications for classification and heat stress response

Annals of Microbiology ◽

10.1007/s13213-014-0862-7 ◽

2014 ◽

Vol 65 (1) ◽

pp. 297-305

Author(s):

Angela Guidone ◽

Eugenio Parente ◽

Teresa Zotta ◽

Caitriona M. Guinane ◽

Mary C. Rea ◽

...

Keyword(s):

Heat Stress ◽

Stress Response ◽

Lactobacillus Plantarum ◽

Heat Stress Response ◽

Stress Response Genes

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Effects of heat stress on the gut health of poultry

Journal of Animal Science ◽

10.1093/jas/skaa090 ◽

2020 ◽

Vol 98 (4) ◽

Cited By ~ 1

Author(s):

Marcos H Rostagno

Keyword(s):

Heat Stress ◽

Stress Response ◽

Production System ◽

Adaptive Response ◽

Intestinal Tract ◽

Scientific Evidence ◽

Gut Health ◽

Heat Stress Response ◽

Targeted Interventions ◽

Animal Production System

Abstract Stress is a biological adaptive response to restore homeostasis, and occurs in every animal production system, due to the multitude of stressors present in every farm. Heat stress is one of the most common environmental challenges to poultry worldwide. It has been extensively demonstrated that heat stress negatively impacts the health, welfare, and productivity of broilers and laying hens. However, basic mechanisms associated with the reported effects of heat stress are still not fully understood. The adaptive response of poultry to a heat stress situation is complex and intricate in nature, and it includes effects on the intestinal tract. This review offers an objective overview of the scientific evidence available on the effects of the heat stress response on different facets of the intestinal tract of poultry, including its physiology, integrity, immunology, and microbiota. Although a lot of knowledge has been generated, many gaps persist. The development of standardized models is crucial to be able to better compare and extrapolate results. By better understanding how the intestinal tract is affected in birds subjected to heat stress conditions, more targeted interventions can be developed and applied.

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Oxidative Stress Impairs the Heat Stress Response and Delays Unfolded Protein Recovery

PLoS ONE ◽

10.1371/journal.pone.0007719 ◽

2009 ◽

Vol 4 (11) ◽

pp. e7719 ◽

Cited By ~ 46

Author(s):

Masaaki Adachi ◽

Yaohua Liu ◽

Kyoko Fujii ◽

Stuart K. Calderwood ◽

Akira Nakai ◽

...

Keyword(s):

Oxidative Stress ◽

Heat Stress ◽

Stress Response ◽

Protein Recovery ◽

Heat Stress Response ◽

Unfolded Protein

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Identification of heat-responsive miRNAs to reveal the miRNA-mediated regulatory network of heat stress response in Betula luminifera

Trees ◽

10.1007/s00468-017-1575-x ◽

2017 ◽

Vol 31 (5) ◽

pp. 1635-1652 ◽

Cited By ~ 8

Author(s):

Ying Pan ◽

Mingyue Niu ◽

Junsheng Liang ◽

Erpei Lin ◽

Zaikang Tong ◽

...

Keyword(s):

Heat Stress ◽

Stress Response ◽

Regulatory Network ◽

Heat Stress Response ◽

Betula Luminifera

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The Heat Stress Transcription Factor LlHsfA4 Enhanced Basic Thermotolerance through Regulating ROS Metabolism in Lilies (Lilium Longiflorum)

International Journal of Molecular Sciences ◽

10.3390/ijms23010572 ◽

2022 ◽

Vol 23 (1) ◽

pp. 572

Author(s):

Chengpeng Wang ◽

Yunzhuan Zhou ◽

Xi Yang ◽

Bing Zhang ◽

Fuxiang Xu ◽

...

Keyword(s):

Heat Stress ◽

Stress Response ◽

Stress Proteins ◽

Lilium Longiflorum ◽

Ros Scavenging ◽

Heat Stress Response ◽

Ros Metabolism ◽

Heat Stress Proteins ◽

Dependent Pathway ◽

Heat Stress Transcription Factors

Heat stress severely affects the annual agricultural production. Heat stress transcription factors (HSFs) represent a critical regulatory juncture in the heat stress response (HSR) of plants. The HsfA1-dependent pathway has been explored well, but the regulatory mechanism of the HsfA1-independent pathway is still under-investigated. In the present research, HsfA4, an important gene of the HsfA1-independent pathway, was isolated from lilies (Lilium longiflorum) using the RACE method, which encodes 435 amino acids. LlHsfA4 contains a typical domain of HSFs and belongs to the HSF A4 family, according to homology comparisons and phylogenetic analysis. LlHsfA4 was mainly expressed in leaves and was induced by heat stress and H2O2 using qRT-PCR and GUS staining in transgenic Arabidopsis. LlHsfA4 had transactivation activity and was located in the nucleus and cytoplasm through a yeast one hybrid system and through transient expression in lily protoplasts. Over expressing LlHsfA4 in Arabidopsis enhanced its basic thermotolerance, but acquired thermotolerance was not achieved. Further research found that heat stress could increase H2O2 content in lily leaves and reduced H2O2 accumulation in transgenic plants, which was consistent with the up-regulation of HSR downstream genes such as Heat stress proteins (HSPs), Galactinol synthase1 (GolS1), WRKY DNA binding protein 30 (WRKY30), Zinc finger of Arabidopsis thaliana 6 (ZAT6) and the ROS-scavenging enzyme Ascorbate peroxidase 2 (APX2). In conclusion, these results indicate that LlHsfA4 plays important roles in heat stress response through regulating the ROS metabolism in lilies.

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