Update on Myositis Therapy: from Today’s Standards to Tomorrow’s Possibilities

: Inflammatory myopathies, in short, myositis, are heterogeneous disorders that are characterized by inflammation of skeletal muscle and weakness of arms and legs. Research over the past few years has led to a new understanding regarding the pathogenesis of myositis. The new insights include different pathways of the innate and adaptive immune response during the pathogenesis of myositis. The importance of non-inflammatory mechanisms such as cell stress and impaired autophagy has been recently described. New target-specific drugs for myositis have been developed and are currently being tested in clinical trials. In this review, we discuss the mechanisms of action of pharmacological standards in myositis and provide an outlook of future treatment approaches.

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Covid-19 Vaccines and their Interchangeability Could be Effective in Developing Countries Like India to Generate Stronger Adaptive Immune Response in Large Population

10.47363/jmhc/2021(3)156 ◽

2020 ◽

pp. 1-3

Author(s):

Saif Ali ◽

Keyword(s):

Immune Response ◽

Developing Countries ◽

Clinical Trials ◽

Large Population ◽

Adaptive Immune Response ◽

Adverse Side Effects ◽

Adaptive Immune ◽

The People ◽

Blood Clots ◽

The World

Vaccine considered as a boon for every individual across the world in the time of pandemic situation. India has developed its own vaccine which shows promising results. Receiving vaccine does not mean that we are completely immune to the disease. Covishield shows some rare but adverse side effects of blood clots in those people having thrombocytopenia. Covaxin has not recorded any such cases as it is of inactivated type. But, the manufacturers of the vaccine have not established the longevity of protection against COVID-19. Unavailability of vaccines in India could pose a serious impact on the lives of the people. Government of India and Medical authorities should take clinical trials and make decision on interchangeability of vaccines as soon as possible.

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Inverse Vaccination to Silence Immunity to Myelin in Multiple Sclerosis

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100022435 ◽

2010 ◽

Vol 37 (S2) ◽

pp. S49-S58 ◽

Cited By ~ 2

Author(s):

Lawrence Steinman

Keyword(s):

Multiple Sclerosis ◽

Immune Response ◽

Clinical Trials ◽

Immune Responses ◽

Large Scale ◽

Adaptive Immune Response ◽

Antibody Responses ◽

Myelin Proteins ◽

Adaptive Immune ◽

Key Drivers

ABSTRACT:The adaptive immune response in multiple sclerosis is complex. We have devised large scale arrays to measure the antibody response to myelin proteins and lipids. Despite the widespread immune responses to myelin, we have devised an inverse vaccine aimed at turning off key drivers of this diverse response. Clinical trials in patients with multiple sclerosis show that it is possible to constrain antibody responses to myelin on a large scale with this approach.

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Covid-19 Vaccines and their Interchangeability Could be Effective in Developing Countries Like India to Generate Stronger Adaptive Immune Response in Large Population

10.47363/jmhc/2021(3)157 ◽

2020 ◽

pp. 1-3

Author(s):

Saif Ali ◽

Keyword(s):

Immune Response ◽

Developing Countries ◽

Clinical Trials ◽

Large Population ◽

Adaptive Immune Response ◽

Adverse Side Effects ◽

Adaptive Immune ◽

The People ◽

Blood Clots ◽

The World

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Dendritic Cells as Arbiters of Peritoneal Immune Responses

Peritoneal Dialysis International ◽

10.1177/089686080602600102 ◽

2006 ◽

Vol 26 (1) ◽

pp. 8-25 ◽

Cited By ~ 6

Author(s):

Michelle L. McCully ◽

Joaquín Madrenas

Keyword(s):

Immune Response ◽

Dendritic Cells ◽

Immune Responses ◽

Adaptive Immune Response ◽

Immune Defense ◽

Dendritic Cell Differentiation ◽

Adaptive Immune ◽

The Past ◽

Key Players ◽

And Function

During the past few years, there has been a substantial increase in the understanding of innate immunity. Dendritic cells are emerging as key players in the orchestration of this early phase of immune responses, with a role that will translate into the subsequent type of adaptive immune response against infection. Here we provide an overview of dendritic cell differentiation and function, with particular emphasis on those features unique to the immune defense of the peritoneal cavity and in the context of peritoneal dialysis-associated immune responses. The reader is referred to the primary references included in the accompanying list for specific details in this fascinating field.

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