Potential Use of Modulators of Oxidative Stress as Add-on Therapy in Patients with Anxiety Disorders

Breast cancer is the most frequent cancer and the leading cause of cancer death in women. Oxidative stress and the generation of reactive oxygen species (ROS) have been related to cancer progression. Compared to their normal counterparts, tumor cells show higher ROS levels and tight regulation of REDOX homeostasis to maintain a low degree of oxidative stress. Traditionally antioxidants have been extensively investigated to counteract breast carcinogenesis and tumor progression as chemopreventive agents; however, there is growing evidence indicating their potential as adjuvants for the treatment of breast cancer. Aimed to elucidate whether antioxidants could be a reality in the management of breast cancer patients, this review focuses on the latest investigations regarding the ambivalent role of antioxidants in the development of breast cancer, with special attention to the results derived from clinical trials, as well as their potential use as plausible agents in combination therapy and their power to ameliorate the side effects attributed to standard therapeutics. Data retrieved herein suggest that antioxidants play an important role in breast cancer prevention and the improvement of therapeutic efficacy; nevertheless, appropriate patient stratification based on “redoxidomics” or tumor subtype is mandatory in order to define the dosage for future standardized and personalized treatments of patients.

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Kefir peptide (Kef-1) as an emerging approach for the treatment of oxidative stress and inflammation in 2K1C mice

Food & Function ◽

10.1039/d1fo01798e ◽

2022 ◽

Author(s):

Rafaela Aires ◽

Fernanda Gobbi Amorim ◽

Larissa Zambom Côco ◽

Amanda Pompermayer da Conceição ◽

Tadeu Ériton Caliman Zanardo ◽

...

Keyword(s):

Oxidative Stress ◽

Angiotensin Converting Enzyme ◽

Ace Inhibitors ◽

Bioactive Molecules ◽

Converting Enzyme ◽

The Rich ◽

Potential Use

The benefits of Kefir consumption are due, in part, to the rich composition of bioactive molecules released from fermentation. Angiotensin-converting enzyme (ACE) inhibitors are bioactive molecules with potential use in...

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Potential use of Internet-based screening for anxiety disorders: a pilot study

Depression and Anxiety ◽

10.1002/da.20723 ◽

2010 ◽

Vol 27 (11) ◽

pp. 1006-1010 ◽

Cited By ~ 11

Author(s):

Michael Van Ameringen ◽

Catherine Mancini ◽

William Simpson ◽

Beth Patterson

Keyword(s):

Pilot Study ◽

Anxiety Disorders ◽

Use Of Internet ◽

Potential Use

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Advances in Chlorophyll Fluorescence Theories: Close Investigation into Oxidative Stress and Potential Use for Plant Breeding

Signaling and Communication in Plants - Redox Homeostasis in Plants ◽

10.1007/978-3-319-95315-1_7 ◽

2019 ◽

pp. 137-154

Author(s):

Etsuko Watanabe ◽

Rym Fekih ◽

Ichiro Kasajima

Keyword(s):

Oxidative Stress ◽

Chlorophyll Fluorescence ◽

Plant Breeding ◽

Close Investigation ◽

Potential Use

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Citrus sinensis and Vitis vinifera Protect Cardiomyocytes from Doxorubicin-Induced Oxidative Stress: Evaluation of Onconutraceutical Potential of Vegetable Smoothies

Antioxidants ◽

10.3390/antiox9050378 ◽

2020 ◽

Vol 9 (5) ◽

pp. 378 ◽

Cited By ~ 1

Author(s):

Giacomo Pepe ◽

Emanuela Salviati ◽

Shara Francesca Rapa ◽

Carmine Ostacolo ◽

Stella Cascioferro ◽

...

Keyword(s):

Oxidative Stress ◽

Vitis Vinifera ◽

Citrus Sinensis ◽

Breast Adenocarcinoma ◽

Vitis Vinifera L ◽

Stress Evaluation ◽

Apoptotic Activity ◽

And Oxidative Stress ◽

Potential Use ◽

Mcf 7

The interest towards nutraceuticals able to counteract drug side effects is continuously growing in current chemotherapeutic protocols. In the present study, we demonstrated that smoothies containing mixtures of Citrus sinensis and Vitis vinifera L. cv. Aglianico N, two typical fruits of the Mediterranean diet, possess bioactive polyphenols that protect cardiomyocytes against doxorubicin-induced oxidative stress. The polyphenolic extracts isolated from Citrus sinensis- and Vitis vinifera-based functional smoothies were deeply characterized by Liquid Chromatography-Mass Spectrometry methods. Subsequently, the functional smoothies and relative mixtures were tested to verify their ability to affect cellular viability and oxidative stress parameters in embryonic cardiomyocyte cells (H9c2), and human breast adenocarcinoma cell line (MCF-7) exposed to doxorubicin. Interestingly, we found that the mix resulting from Citrus sinensis and Vitis vinifera association in ratio 1:1 was able to reduce cardiomyocytes damage induced by anthracyclines, without significantly interfering with the pro-apoptotic activity of the drug on breast cancer cells. These results point out the potential use of vegetable smoothies as adjuvants functional foods for chemotherapeutic anticancer protocols.

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Comparative Phytochemical, Antioxidant and Haemostatic Studies of Preparations from Selected Vegetables from Cucurbitaceae Family

Molecules ◽

10.3390/molecules25184326 ◽

2020 ◽

Vol 25 (18) ◽

pp. 4326

Author(s):

Agata Rolnik ◽

Iwona Kowalska ◽

Agata Soluch ◽

Anna Stochmal ◽

Beata Olas

Keyword(s):

Oxidative Stress ◽

Thrombin Time ◽

Phytochemical Composition ◽

Significant Interest ◽

Phytochemical Compounds ◽

Potential Use ◽

Insight Into ◽

Cucurbitaceae Family

The aim of this study was to provide detailed insight into the chemical composition and activity of five cucurbit vegetable preparations (pumpkin, zucchini, cucumber, white and yellow pattypan squash), each containing various phytochemical compounds with potential use against oxidative stress induced by the hydroxyl radical donors in human plasma in vitro. We studied the antiradical capacity of vegetable preparations using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. As oxidative stress may induce changes in hemostasis, our aim included the determination of their effect on three selected hemostatic parameters of plasma, which are three coagulation times: PT (prothrombin time), APTT (activated partial thromboplastin time) and TT (thrombin time). However, none of used vegetable preparations changed APTT, PT or TT compared to the control. The phytochemical composition of the tested preparations was determined by UPLC-ESI-QTOF-MS. In our in vitro experiments, while all five tested preparations had antioxidant potential, the preparation from yellow pattypan squash showed the strongest potential. All cucurbit vegetable preparations inhibited lipid peroxidation. Only zucchini did not have an effect on protein carbonylation and only yellow pattypan squash inhibited thiol oxidation. The antioxidant activity of cucurbits appears to have triggered significant interest in multiple applications, including CVDs (cardiovascular diseases) associated with oxidative stress, which can be treated by supplementation based on these vegetables.

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Preliminary N-acetylcysteine results for LDN 6722 - Role of oxidative stress and inflammation in Gaucher disease type 1: Potential use of antioxidant anti-inflammatory medications

Molecular Genetics and Metabolism ◽

10.1016/j.ymgme.2018.12.201 ◽

2019 ◽

Vol 126 (2) ◽

pp. S82

Author(s):

Reena V. Kartha ◽

James Joers ◽

Marcia Terluk ◽

Paul Tuite ◽

Usha Mishra ◽

...

Keyword(s):

Oxidative Stress ◽

Gaucher Disease ◽

Disease Type ◽

Gaucher Disease Type 1 ◽

Anti Inflammatory ◽

Potential Use

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Oxidative stress and ageing of the post-ovulatory oocyte

Reproduction ◽

10.1530/rep-13-0111 ◽

2013 ◽

Vol 146 (6) ◽

pp. R217-R227 ◽

Cited By ~ 99

Author(s):

Tessa Lord ◽

R John Aitken

Keyword(s):

Oxidative Stress ◽

Molecular Mechanisms ◽

Embryo Quality ◽

Fertilization Rates ◽

Molecular Events ◽

Post Implantation ◽

Potential Use

With extended periods of time following ovulation, the metaphase II stage oocyte experiences deterioration in quality referred to as post-ovulatory oocyte ageing. Post-ovulatory ageing occurs both in vivo and in vitro and has been associated with reduced fertilization rates, poor embryo quality, post-implantation errors and abnormalities in the offspring. Although the physiological consequences of post-ovulatory oocyte ageing have largely been established, the molecular mechanisms controlling this process are not well defined. This review analyses the relationships between biochemical changes exhibited by the ageing oocyte and the symptoms associated with the ageing phenotype. We also discuss molecular events that are potentially involved in orchestrating post-ovulatory ageing with a particular focus on the role of oxidative stress. We propose that oxidative stress may act as the initiator for a cascade of events that create the aged oocyte phenotype. Specifically, oxidative stress has the capacity to cause a decline in levels of critical cell cycle factors such as maturation-promoting factor, impair calcium homoeostasis, induce mitochondrial dysfunction and directly damage multiple intracellular components of the oocyte such as lipids, proteins and DNA. Finally, this review addresses current strategies for delaying post-ovulatory oocyte ageing with a particular focus on the potential use of compounds such as caffeine or selected antioxidants in the development of more refined media for the preservation of oocyte integrity during IVF procedures.

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