Selenium Compounds and Apoptotic Modulation: A New Perspective in Cancer Therapy

2008 ◽  
Vol 8 (10) ◽  
pp. 1020-1031 ◽  
Author(s):  
Carmen Sanmartin ◽  
Daniel Plano ◽  
Juan Palop
Keyword(s):  
Cancer Therapy ◽  
Selenium Compounds ◽  
New Perspective

scholarly journals The Multifaceted Role of Flavonoids in Cancer Therapy: Leveraging Autophagy with a Double-Edged Sword

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1138
Author(s):  
Zhe Zhang ◽  
Jiayan Shi ◽  
Edouard C. Nice ◽  
Canhua Huang ◽  
Zheng Shi
Keyword(s):  
Cancer Therapy ◽  
Dosage Forms ◽  
Pharmacological Effects ◽  
Autophagy Flux ◽  
Normal Tissues ◽  
Anti Cancer ◽  
New Perspective ◽  
New Research ◽  
Cancer Activity

Flavonoids are considered as pleiotropic, safe, and readily obtainable molecules. A large number of recent studies have proposed that flavonoids have potential in the treatment of tumors by the modulation of autophagy. In many cases, flavonoids suppress cancer by stimulating excessive autophagy or impairing autophagy flux especially in apoptosis-resistant cancer cells. However, the anti-cancer activity of flavonoids may be attenuated due to the simultaneous induction of protective autophagy. Notably, flavonoids-triggered protective autophagy is becoming a trend for preventing cancer in the clinical setting or for protecting patients from conventional therapeutic side effects in normal tissues. In this review, focusing on the underlying autophagic mechanisms of flavonoids, we hope to provide a new perspective for clinical application of flavonoids in cancer therapy. In addition, we highlight new research ideas for the development of new dosage forms of flavonoids to improve their various pharmacological effects, establishing flavonoids as ideal candidates for cancer prevention and therapy in the clinic.

scholarly journals Selenium Compounds, Apoptosis and Other Types of Cell Death: An Overview for Cancer Therapy

2012 ◽  
Vol 13 (8) ◽  
pp. 9649-9672 ◽  
Author(s):  
Carmen Sanmartín ◽  
Daniel Plano ◽  
Arun K. Sharma ◽  
Juan Antonio Palop
Keyword(s):  
Cell Death ◽  
Cancer Therapy ◽  
Selenium Compounds

The Role of Selenium Compounds in Cancer Therapy

1986 ◽  
Vol 5 (1) ◽  
pp. 87-93 ◽  
Author(s):  
G. Batist ◽  
A.G. Katki ◽  
V.J. Ferrans ◽  
C.E. Myers
Keyword(s):  
Experimental Data ◽  
Cancer Therapy ◽  
Antitumor Activity ◽  
Liver Enzymes ◽  
Selenium Deficiency ◽  
Organic Peroxides ◽  
Tumor Cell Lines ◽  
Selenium Compounds ◽  
The Impact

Experimental evidence is presented that demonstrates the impact of selenium on the effects of a variety of anticancer treatments, including chemotherapy and radiation. Selenium-dependent glutathione peroxidase can detoxify organic peroxides resulting from some of these treatments. Selenium deficiency has also been associated with significant changes in liver enzymes that activate some drugs and contribute to detoxification. Some forms of free selenium have cytotoxicity against a variety of tumor cell lines, both murine and human. Experimental data suggest that catalytic oxidation of cellular glutathione and reduction of molecular oxygen are part of the mechanism of this antitumor activity. This provides provocative possibilities for the inclusion of selenium into cancer therapy regimens.

Abstract 4550: Antiproliferative activity of 8-methoxypsoralen without UV light irradiation: A new perspective for cancer therapy

2015 ◽  
Author(s):  
Diêgo M. de Oliveira ◽  
Rute M F Lima ◽  
Eudes S. Velozo ◽  
Ilza A. Amorim ◽  
Tales H A Mota ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Antiproliferative Activity ◽  
Uv Light ◽  
Light Irradiation ◽  
Uv Light Irradiation ◽  
New Perspective

Managing lipid metabolism in proliferating cells: New perspective for metformin usage in cancer therapy

2014 ◽  
Vol 1845 (2) ◽  
pp. 317-324 ◽  
Author(s):  
Daniele Lettieri Barbato ◽  
Rolando Vegliante ◽  
Enrico Desideri ◽  
Maria Rosa Ciriolo
Keyword(s):  
Lipid Metabolism ◽  
Cancer Therapy ◽  
Proliferating Cells ◽  
New Perspective

scholarly journals Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

2010 ◽  
Vol 9 (5) ◽  
pp. 1092-1099 ◽  
Author(s):  
Issam Ben Sahra ◽  
Yannick Le Marchand-Brustel ◽  
Jean-François Tanti ◽  
Frédéric Bost
Keyword(s):  
Cancer Therapy ◽  
Antidiabetic Drug ◽  
New Perspective

scholarly journals Development of Store-Operated Calcium Entry-Targeted Compounds in Cancer

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiaojing Liang ◽  
Ningxia Zhang ◽  
Hongming Pan ◽  
Jiansheng Xie ◽  
Weidong Han
Keyword(s):  
Cancer Therapy ◽  
Mammalian Cells ◽  
Antitumor Immunity ◽  
Mechanisms Of Action ◽  
Tumor Formation ◽  
Effective Strategy ◽  
Cellular Functions ◽  
Major Pathway ◽  
Store Operated Calcium Entry ◽  
New Perspective

Store-operated Ca2+ entry (SOCE) is the major pathway of Ca2+ entry in mammalian cells, and regulates a variety of cellular functions including proliferation, motility, apoptosis, and death. Accumulating evidence has indicated that augmented SOCE is related to the generation and development of cancer, including tumor formation, proliferation, angiogenesis, metastasis, and antitumor immunity. Therefore, the development of compounds targeting SOCE has been proposed as a potential and effective strategy for use in cancer therapy. In this review, we summarize the current research on SOCE inhibitors and blockers, discuss their effects and possible mechanisms of action in cancer therapy, and induce a new perspective on the treatment of cancer.

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