Review on Characteristics and Analytical Methods of Remogliflozin etabonate: An Update

2021 ◽  
Vol 21 ◽  
Author(s):  
Vallabh D. Suryavanshi ◽  
Sanjay Sharma ◽  
Jagdish K Sahu
Keyword(s):  
Diabetes Mellitus ◽  
Liquid Chromatography ◽  
Side Effects ◽  
Analytical Methods ◽  
High Performance ◽  
Analytical Techniques ◽  
Pharmacodynamic Profile ◽  
Cardiac Disorders ◽  
Silver Lining ◽  
Remogliflozin Etabonate

: Hyperglycemia and its associated disorders like Diabetes mellitus are engulfing the world’s population at a faster pace. New-age medications like the SGLT 2 inhibitors have found their place in the run to combat DM. Drugs with these properties have proven to be effective in treating hyperglycemia, Obesity, and major Cardiac disorders. The interesting fact about these drugs is that they act independently of insulin levels in the patient’s body. The fact that they even bypass the side effects shown by currently used anti-diabetic medications has attracted the world’s hope to neutralize diabetes mellitus. The invention of Remogliflozin etabonate (RGE), an SGLT 2 inhibitor, has therefore added a silver lining to the gliflozin-family of drugs in the fight against DM. This is due to its least side effects as well as its effective mechanisms to treat hyperglycemia. It can be administered not only as a single entity but also can be co-administered in combination with other anti-hyperglycemic agents. RGE is already sold in the Indian market as REMO-ZEN, by Glenmark Pharmaceuticals. It has been studied thoroughly for its pharmacokinetic & pharmacodynamic profile. It is a benzylpyrazole glucoside. Various analytical methods have been formulated for its detection, quantification, and routine quality control activities. RGE can be studied with the help of UV-visible spectrophotometry, High-Performance Liquid Chromatography (HPLC) & Hyphenated techniques like Liquid Chromatography-Mass Spectroscopy (LC-MS/MS). This review briefs about overall chemical, pharmacological, pharmacokinetic & pharmacodynamics properties of RGE. It mainly discusses about various analytical techniques used for determining & estimating RGE.

Proton pump inhibitors: recent developments in analytical methodologies

2015 ◽  
Vol 34 (1-2) ◽  
Author(s):  
Mehul M. Patel ◽  
Satish D. Bhuva ◽  
Miketa M. Patel
Keyword(s):  
Liquid Chromatography ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Analytical Methods ◽  
High Performance ◽  
Biological Fluids ◽  
Ultra Violet ◽  
Analytical Techniques ◽  
Pharmaceutical Chemistry

AbstractAn extensive survey of the literature published in various analytical and pharmaceutical chemistry-related journals have been conducted, and the instrumental analytical methods that were developed and used for the determination of proton pump inhibitors in bulk drugs, formulations, and biological fluids have been reviewed. This review covers the time period from 1990 to 2011 during which 80 analytical methods, including all types of spectrophotometric and chromatographic techniques were reported. High-performance liquid chromatography (HPLC) with ultra violet (UV) detection was found to be the technique of choice for many workers, and more than 50 methods were based on liquid chromatography (LC) and ultra violet (UV). A critical analysis of the reported data was carried out and the present state of the art of the analytical techniques for the determination of omeprazole, esomeprazole, pantoprazole, rabeprazole, dexrabeprazole, tenatoprazole, lansoprazole, and dexlansoprazole is discussed.

scholarly journals METHODICAL INSIGHTS INTO REPORTED SOPHISTICATED ANALYTICAL TECHNIQUES FOR THE DETERMINATION OF ANTI-DIABETIC DRUG EMPAGLIFLOZIN IN VARIOUS PHARMACEUTICAL PRODUCTS

2021 ◽  
Vol 10 (4) ◽  
pp. 3206-3211
Author(s):  
Kishor Danao
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Human Plasma ◽  
Analytical Methods ◽  
High Performance ◽  
Competitive Inhibition ◽  
Analytical Techniques ◽  
Pharmaceutical Products ◽  
Good Precision ◽  
Medical Practitioners

Empagliflozin (EMPA), chemically known as (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol is an oral anti-diabetic drug used for treating type 2 diabetes mellitus that produces hypoglycemia by selective and competitive inhibition of sodium/glucose co-transporter-2 (SGLT2) protein. Currently, EMPA is an emerging drug being prescribed by medical practitioners. The quality-oriented scheduled investigation of diverse commercially obtainable formulations of EMPA is a foremost challenge and recently few sophisticated analytical methods are reported for industrial-scale quantitative analysis. Review of analytical method of antidiabetic drug Empagliflozin. This interesting review article covered the recently published sophisticated instruments-based analytical methods in numerous pharmaceutical databases like PubMed, Google Scholar, Science Direct, etc. of diverse areas like spectrophotometry (Ultraviolet-Visible), Ultra-high Performance Liquid Chromatography (UPLC), High-Performance Liquid Chromatography (HPLC), High-Performance Thin Layer Chromatography (HPTLC), and analytical methods for estimation of EPMA in human plasma. From literature, about 19 HPLC methods, 4 UPLC methods, 15 UV-Vis methods, 3 HPTLC methods, and 4 human plasma-based methods were reported for the estimation of EMPA alone or in combination with other drug substances (Linagliptin, Canagliflozin, Dapagliflozin, and Metformin). The methodical insights outlined the reported characteristics like method, detection wavelength, solvent, % recovery, LOD, LOQ, mobile phase composition, flow-rate, column type, retention time, etc. This review concluded that the developed validated analytical methods have a high degree of accuracy, superior reliability, economical to apply, bears good precision, possess better robustness, and greater reproducible attributes which are compulsory features of an ideal method.

scholarly journals ROBUSTNESS EVALUATION OF HPLC DETERMINATION OF ATORVASTATIN AND LISINOPRIL ON COLUMN PUROSPHER C8 STAR IN PHARMACEUTICALS

2021 ◽  
pp. 21-26
Author(s):  
N. S. Shulyak ◽  
A. D. Abbeyquaye ◽  
D. B. Koval
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Analytical Methods ◽  
High Performance ◽  
Antihypertensive Drugs ◽  
Hplc Method ◽  
Fixed Dose ◽  
Control Analysis ◽  
Chromatography Method ◽  
Pharmaceutical Development

Introduction. Innovative pharmaceutical development of various antihypertensive drugs with statins and the creation of domestic fixed-dose combinations of drugs with different effects is an urgent task of modern pharmacy, which will help attract more patients to the treatment and prevention of cardiovascular disease. Pharmaceutical development of atorvastatin and lisinopril by our scientific group proposes for using the ratio of (1/1) for lisinopril (10 mg) and atorvastatin (10 mg). HPLC (High-Performance Liquid Chromatography) technique is adopted as it is considered as the most common technique in realm of quality control analysis. The aim of the study – to evaluate the robustness of HPLC (High-Performance Liquid Chromatography) method for the quantitation of lisinopril and atorvastatin and determine the analytical parameters that present greater influence in the final results of the analysis. Research Methods. An efficient method to assess the robustness of analytical methods is by Youden’s test, by means of an experiment design which involves seven analytical parameters combined in eight tests. In the recent studies, we assessed the robustness of a chromatographic method to quantify lisinopril and atorvastatin in tablets using Youden’s test. Results and Discussion. By using the criteria of Youden’s test, HPLC method proved to be greatly robust regarding content of lisinopril and atorvastatin, when variations in seven analytical parameters were introduced. The most variation in effects of the analytical parameters in retention time (Rt) for lisinopril and atorvastatin HPLC quantitation was when used column supplier. Purospher C8 STAR (55 mm x 4mm, 5 μm) is based on high purity silica and an almost complete surface coverage. Purospher C8 STAR provides excellent peak symmetry for acidic, basic and even chelating compounds, highest column efficiency in terms of the number of theoretical plates, and exceptional stability from pH 1.5 to 10.5. Conclusion. Youden’s test can be applied successfully for the ro­bustness evaluation in validation process of analytical methods and results ontained in our work should be interest to the scientific population dealing with pharmaceutical analytical chemistry.

scholarly journals ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF COMBINATION OF ANTI-ASTHMATIC DRUGS MONTELUKAST AND DOXOFYLLINE

2021 ◽  
Vol 11 (6) ◽  
pp. 86-91
Author(s):  
Sachin N. Kapase
Keyword(s):  
Liquid Chromatography ◽  
High Performance ◽  
Method Development ◽  
Analytical Techniques ◽  
Ultra Performance Liquid Chromatography ◽  
Hplc Method ◽  
Uv Spectrophotometry ◽  
Method Development And Validation ◽  
Development And Validation ◽  
Layer Chromatography

For qualitative and quantitative analysis, various analytical techniques are available such as Ultraviolet (UV) Spectrophotometry, High-performance liquid chromatography (HPLC), High-performance thin layer chromatography (HPTLC). As per literature survey, there are some UV, HPLC, Ultra-Performance Liquid Chromatography (UPLC) and HPTLC analytical methods are developed for Montelukast and Doxofylline individually and in a combination with other drugs too, since yet there are no significant stability studies indicating HPLC method reported for Montelukast and Doxofylline combinations. In the current study, the HPLC method is developed and validated for simultaneous quantitative estimations of Montelukast and Doxofylline. These present techniques are more efficient and sensitive as compared to other analytical techniques.

scholarly journals An intercomparison study of analytical methods used for quantification of levoglucosan in ambient aerosol filter samples

2014 ◽  
Vol 7 (7) ◽  
pp. 7397-7450 ◽  
Author(s):  
K. E. Yttri ◽  
J. Schnelle-Kreiss ◽  
W. Maenhaut ◽  
C. Alves ◽  
R. Bossi ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Biomass Burning ◽  
Analytical Methods ◽  
High Performance ◽  
Ambient Air ◽  
Ambient Aerosol ◽  
Wood Burning ◽  
Monosaccharide Anhydrides ◽  
The Mean ◽  
Aerosol Filter

Abstract. The monosaccharide anhydrides (MAs) levoglucosan, galactosan and mannosan are products of incomplete combustion and pyrolysis of cellulose and hemicelluloses, and are found to be major constituents of biomass burning aerosol particles. Hence, ambient aerosol particle concentrations of levoglucosan are commonly used to study the influence of residential wood burning, agricultural waste burning and wild fire emissions on ambient air quality. A European-wide intercomparison on the analysis of the three monosaccharide anhydrides was conducted based on ambient aerosol quartz fiber filter samples collected at a Norwegian urban background site during winter. Thus, the samples' content of MAs is representative for biomass burning particles originating from residential wood burning. The purpose of the intercomparison was to examine the comparability of the great diversity of analytical methods used for analysis of levoglucosan, mannosan and galactosan in ambient aerosol filter samples. Thirteen laboratories participated, of which three applied High-Performance Anion-Exchange Chromatography (HPAEC), four used High-Performance Liquid Chromatography (HPLC) or Ultra-Performance Liquid Chromatography (UPLC), and six resorted to Gas Chromatography (GC). The analytical methods used were of such diversity that they should be considered as thirteen different analytical methods. All of the thirteen laboratories reported levels of levoglucosan, whereas nine reported data for mannosan and/or galactosan. Eight of the thirteen laboratories reported levels for all three isomers. The accuracy for levoglucosan, presented as the mean percentage error (PE) for each participating laboratory, varied from −63 to 23%; however, for 62% of the laboratories the mean PE was within ±10%, and for 85% the mean PE was within ±20%. For mannosan, the corresponding range was −60 to 69%, but as for levoglucosan, the range was substantially smaller for a subselection of the laboratories; i.e., for 33% of the laboratories the mean PE was within ±10%. For galactosan, the mean PE for the participating laboratories ranged from −84 to 593%, and as for mannosan 33% of the laboratories reported a mean PE within ±10%. The variability of the various analytical methods, as defined by their minimum and maximum PE value, was typically better for levoglucosan than for mannosan and galactosan, ranging from 3.2 to 41% for levoglucosan, from 10 to 67% for mannosan, and from 6 to 364% for galactosan. For the levoglucosan to mannosan ratio, which may be used to assess the relative importance of softwood vs. hardwood burning, the variability only ranged from 3.5 to 24%. To our knowledge, this is the first major intercomparison on analytical methods used to quantify monosaccharide anhydrides in ambient aerosol filter samples conducted and reported in the scientific literature. The results show that for levoglucosan the accuracy is only slightly lower than that reported for analysis of SO42− on filter samples, a constituent that has been analyzed by numerous laboratories for several decades, typically by ion chromatography, and which is considered a fairly easy constituent to measure. Hence, the results obtained for levoglucosan with respect to accuracy are encouraging and suggest that levels of levoglucosan, and to a lesser extent mannosan and galactosan, obtained by most of the analytical methods currently used to quantify monosaccharide anhydrides in ambient aerosol filter samples, are comparable. Finally, the various analytical methods used in the current study should be tested for other aerosol matrices and concentrations as well, the most obvious being summertime aerosol samples affected by wild fires and/or agricultural fires.

scholarly journals ASSESSMENT OF CHROMATOGRAPHIC SEPARATIONS FOR ANTIHYPERTENSIVE AND ANTIDIABETIC DRUGS

2018 ◽  
Vol 11 ◽  
Author(s):  
Sowmyalakshmi Venkataraman ◽  
Haritha G
Keyword(s):  
Liquid Chromatography ◽  
Mass Spectroscopy ◽  
High Performance ◽  
Antihypertensive Drugs ◽  
Analytical Techniques ◽  
Antidiabetic Drugs ◽  
Assay Method ◽  
Related Substance ◽  
Pharmaceutical Dosage Form ◽  
Chromatographic Methods

Context: The focus of this review is to compile the different chromatographic methods that were reported earlier for the analysis of different antihypertensive and antidiabetic drugs. Objective: The magnitude of chemical entities investigated and entering into the medicinal field for various health-related ailments is escalating year after year. The drugs are either innovative entities or fractional structural variation of the preexisting chemical molecule. These drugs may exhibit unexpected toxicities after Phase IV of clinical trials, resulting in their withdrawal from the market. Under these circumstances, analytical measures for these drugs may not be accessible in the pharmacopeias. The main aim of this work is to compile the different analytical techniques for the quantification of various antihypertensive drugs and antidiabetic drugs. Methods: The present work is to thoroughly study the literature for the application of different analytical techniques such as high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectroscopy/tandem mass spectroscopy (LC-MS/MS) for the quantification of antihypertensive drugs and anti-diabetic drugs. Results: The present study attempts to collate various analytical techniques that were developed and validated for the estimation of few important antidiabetic and antihypertensive drugs either in pure, individually or combined with other pharmaceutical dosage form by HPLC, LC-MS/MS, and high-performance thin-layer chromatography techniques. Conclusion: Different chromatographic methods are considered to be rapid tools for qualitative and quantitative analysis of newer chemical entities in pharmaceuticals. The amount of these newer chemical entities which are reaching the pharmaceutical market is increasing day by day nevertheless there exists a lag in establishing the standard protocols for the identification, impurity profiling, related substance and assay method. Hence, the present review compiles the different analytical methods that were reported in the literature and thus helps the researchers and chemists to make use of the analytical techniques for the quantification and validation of various antidiabetic and antihypertensive drugs.

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