Insight into the Isolation, Synthesis and Structure-Activity Relationship of Piperine Derivatives for the Development of New Compounds: Recent Updates

2021 ◽  
Vol 21 ◽  
Author(s):  
Afreen ◽  
Salahuddin ◽  
Avijit Mazumder ◽  
Sagar Joshi ◽  
Rajnish Kumar ◽  
...  
Keyword(s):  
Dietary Habits ◽  
Complete Information ◽  
Chemical Constituent ◽  
Black Pepper ◽  
Piper Nigrum ◽  
Assisted Extraction ◽  
Current Survey ◽  
Ultrasonic Assisted ◽  
Leading Position ◽  
Relationship Of

: Currently, black pepper commands the leading position among all the spices as a spice of handsome commercial importance in all the world trade and finds its way into the dietary habits of millions of people worldwide. Black pepper is biologically known as Piper nigrum and contains Piperine as the main active chemical constituent. This paper highlights various general methods for extracting Piperine from the crude drug: maceration extraction, Hydrotropic extraction, Accelerated solvent extraction, Thin layer chromatography, and extraction with ethanol & dichloromethane Ionic fluid-based ultrasonic-assisted extraction, etc. In this review, Piperine and its analogs exhibit numerous pharmacological activities and synthetic schemes of Insecticidal activity, Anti-cancer activity, Anti-inflammatory activity, Anti-diabetic activity, Anti-hyperlipidemic activity, Antifungal Activity, Narcotic Activity, etc. The biochemistry of Piperine also has been summarized in the presented article. This very exhaustive review details the complete information about Piperine, its derivatives, and further processing. Moreover, the current survey sums up the new writing identified with Piperine as a remedial specialist against a few illnesses.

scholarly journals Studi Model Kinetika Ekstraksi Berbantu Ultrasonik pada Lada (Piper nigrum L.)

2021 ◽  
Vol 9 (3) ◽  
pp. 127-134
Author(s):  
Anggie Yulia Sari ◽  
I Wayan Budiastra ◽  
Slamet Widodo
Keyword(s):  
Piper Nigrum ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction

Ultrasonic Assisted Extraction (UAE) digunakan untuk mengekstraksi oleoresin dari lada yang memberikan metode yang lebih kompetitif dibandingkan dengan metode maserasi. Penelitian ini bertujuan untuk mempelajari dan melakukan validasi model orde kedua dari model kinetika ekstraksi berbantu UAE pada lada putih yang dapat menggambarkan hubungan antara rendemen oleoresin, amplitudo UAE dan waktu ekstraksi. Biji lada digiling hingga memiliki ukuran partikel sebesar 100 mesh. Ekstraksi UAE dilakukan dengan menambahkan 200 g bubuk lada ke dalam 800 ml etanol (1:4). Proses maserasi juga dilakukan sebagai perlakuan kontrol. Amplitudo dan waktu ekstraksi yang digunakan dalam ekstraksi berrbantu UAE adalah 45, 60, 75, dan 90 %; dan 45, 60, 75, dan 90 menit. Nilai eksperimen konsentrasi oleoresin lada putih (Ct) dan perhitungan model sangat berkaitan dengan kapasitas ekstraksi saat saturasi (Cs) dan konstanta laju ekstraksi (k). Nilai Cs berkisar antara 29,24–34,48 g/l dan nilai k berkisar antara  l/g.menit. Perolehan hasil dari kedua Ct menghasilkan nilai koefisien korelasi sebesar 0,85 dan nilai galatnya pada perhitungan model berkisar antara 0,18–14,09 %. Model kinetik orde kedua yang dikembangkan dapat digunakan untuk memprediksi hasil rendemen oleoresin lada putih berbantu UAE dengan kondisi batas amplitudo UAE 45–90 % dan waktu ekstraksi 45–90 menit.

Antileishmanial Alkaloids from Black Pepper (Piper nigrum)

Planta Medica ◽  
2011 ◽  
Vol 77 (05) ◽  
Author(s):  
HRW Dharmaratne ◽  
BL Tekwani ◽  
NPD Nanayakkara
Keyword(s):  
Black Pepper ◽  
Piper Nigrum

DETERMINATION OF THE EFFICIENCY AND EFFICACY OF BIO-CHEMICAL FERTILIZER ON THE SOIL, YIELD AND GROWTH PERFORMANCE OF BLACK PEPPER (Piper nigrum L.)

2015 ◽  
Vol 4 (3) ◽  
pp. 460-468
Author(s):  
Yap Chin Ann
Keyword(s):  
Growth Performance ◽  
Nutrient Management ◽  
High Growth ◽  
Black Pepper ◽  
Chemical Fertilizer ◽  
Piper Nigrum ◽  
High Fertility ◽  
Fertility Level ◽  
Area Index ◽  
K 12

The last nutrient management review of black pepper was done in 1968. There is, therefore, a need to develop new technology to improve pepper production and transfer that technology to production site. This experiment was carried out to study the effect of newly developed biochemical fertilizer on some physiological characteristics, yield and soil fertility of pepper. The treatment consisted of T1 (BS): chemical fertilizer (N:12%, P:12%, K:17%); T2 (BK1): biochemical fertilizer F1 N:15%, P:5%, K:14) and T3 (BK2): biochemical fertilizer F2 (N:13%, P:4%, K:12). The biochemical fertilizer F1 out-yielded chemical and biochemical fertilizer F2 by 75.38% and 16.45% respectively with the higher yield being associated with various phonotypical alterations, which are reported here. Significant measureable changes were observed in physiological processes and plant characteristics, such as large leaf area index, more chlorophyll content and high photosynthesis rate coupled with lower transpiration rate in biochemical fertilizer F1(BK1) treatment compared with other treatment. The high fertility level in biochemical fertilizer F1 and biochemical fertilizer F2 (BK2) reflected the important of organic material in improving soil quality. In conclusion, the achieve high growth performance and yield in pepper, chemical fertilizer alone is insufficient whilst combination of organic and inorganic fertilizer with balance nutrient content gave a significant increase in yield and growth of pepper. 

HPLC analysis and activity to determine the effect of drying and extraction on Ficus benghalensis leaves

2020 ◽  
Vol 9 (1) ◽  
pp. 6-10
Author(s):  
Nithyakalyani K
Keyword(s):  
Extraction Method ◽  
Chemical Constituents ◽  
Extraction Procedure ◽  
Chemical Constituent ◽  
Chemical Components ◽  
Drying Method ◽  
Ultrasound Assisted Extraction ◽  
Critical Stage ◽  
Ficus Benghalensis ◽  
Assisted Extraction

Ficus benghalensis is one of those taboo plants in India, which was claimed to be possessed and have weird effects on human health. Apart from this ficus species has a great variety of chemical constituents and an abundant amount of antioxidants. Drying is the most critical stage of improving the activity or preventing the loss of chemical components from a drug. There is another stage of ensuring high chemical constituent content in the plant and that is the extraction procedure. So the point of focus in the current research is to find the effect of extraction method and drying on the anti-inflammatory potential of the plant. The result of the extraction method and drying method of the plant was investigated and found that the ultrasound-assisted extraction of the shade dried leaves was found to give the highest yield of flavonoids and activity.

scholarly journals Combining Normal/Reversed-Phase HPTLC with Univariate Calibration for the Piperine Quantification with Traditional and Ultrasound-Assisted Extracts of Various Food Spices of Piper nigrum L. under Green Analytical Chemistry Viewpoint

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 732
Author(s):  
Mohammed H. Alqarni ◽  
Prawez Alam ◽  
Ahmed I. Foudah ◽  
Magdy M. Muharram ◽  
Faiyaz Shakeel
Keyword(s):  
Analytical Chemistry ◽  
High Performance ◽  
Black Pepper ◽  
Reversed Phase ◽  
Normal Phase ◽  
Piper Nigrum ◽  
Green Analytical Chemistry ◽  
Pharmaceutical Samples ◽  
Analytical Technique ◽  
Ultrasound Assisted

Due to unavailability of sustainable analytical techniques for the quantitation of piperine (PPN) in food and pharmaceutical samples, there was a need to develop a rapid and sensitive sustainable analytical technique for the quantitation of PPN. Therefore, the current research presents a fast and highly sensitive normal/reversed-phase high-performance thin-layer chromatography (HPTLC) technique with classical univariate calibration for the quantitation of PPN in various food spices of black pepper with traditional (TE) and ultrasound-assisted extracts (UBE) of various food spices of Piper nigrum L. under green analytical chemistry viewpoint. The amount of PPN in TE of four different spices of black pepper—namely BPMH, BPLU, BPSH, and BPPA—was found to be 309.53, 304.97, 282.82, and 232.73 mg g−1, respectively using a sustainable normal-phase HPTLC technique. However, the amount of PPN in UBE of BPMH, BPLU, BPSH, and BPPA was recorded as 318.52, 314.60, 292.41, and 241.82 mg g−1, respectively using a sustainable normal phase HPTLC technique. The greenness of normal/reversed-phase HPTLC technique was predicted using AGREE metric approach. The eco-scale was found to be 0.90, suggested excellent greenness of normal/reversed-phase technique. UBE of PPN was also found to be superior over TE of PPN. Overall, the results of this research suggested that the proposed normal/reversed-phase densitometry technique could be effectively used for the quantitation of PPN in food and pharmaceutical samples.

scholarly journals Optimizing the ultrasonic-assisted extraction of antioxidants from Ulva lactuca algal biomass using factorial design

2021 ◽  
Author(s):  
Sayed Rashad ◽  
Ghadir El-Chaghaby ◽  
Eder C. Lima ◽  
Glaydson Simoes dos reis
Keyword(s):  
Factorial Design ◽  
Algal Biomass ◽  
Ulva Lactuca ◽  
Extraction Technique ◽  
Extraction Solvent ◽  
Assisted Extraction ◽  
Study Results ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction ◽  
Optimum Extraction

AbstractUltrasonic-assisted extraction (UAE) is increasingly emerging as a highly effective extraction technique. This extraction technique is affected by several experimental factors. The present work aimed to optimize the ultrasonic-assisted extraction of antioxidants from Ulva lactuca (sea lettuce), widespread macroalgae growing along the Mediterranean coast. In this respect, a full-factorial design (23) was employed to assess the effect of three different factors at two levels and their interactions on the extraction of antioxidants from sea lettuce algal biomass. The studied factors were extraction solvent, time of extraction, and temperature. The two levels chosen for extraction solvent were 100% ethanol and 50% ethanol, for the sonication time (1 h and 3 h) and temperature (25 °C and 40 °C). All experiments were done using an ultrasonic bath, and the biomass to solvent ratio was kept at 1:5. Total antioxidant capacity and quercetin concentration were set as the two responses for optimum output. The results showed that the temperature and solvent were the dominating factors that significantly affect the extraction process. The optimum extraction parameters were extraction time of 1 h, 50% ethanol, and temperature of 25 °C. Under these conditions, the maximum value for TAA was calculated as 2166.51 mg of ascorbic acid equivalent per gram (mg/g of AAE), and quercetin showed a maximum calculated value of 42.5 mg/g with combined desirability of 0.91 for the two responses. The present study results indicate that U. lactuca can be used as a source of antioxidants and phenolic compounds that can be applied in food and medicine at optimum extraction conditions. Graphical abstract

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