Natural Phenolic Compounds as Cardiovascular Therapeutics: Potential Role of their Antiinflammatory Effects

2003 ◽  
Vol 1 (2) ◽  
pp. 135-156 ◽  
Author(s):  
Fan Jiang ◽  
Gregory Dusting
Molecules ◽  
2015 ◽  
Vol 20 (3) ◽  
pp. 4655-4680 ◽  
Author(s):  
Jose Rodríguez-Morató ◽  
Laura Xicota ◽  
Montse Fitó ◽  
Magí Farré ◽  
Mara Dierssen ◽  
...  

2020 ◽  
Vol 28 (2) ◽  
pp. 195-205
Author(s):  
Gow-Chin Yen ◽  
Hsin-Lin Cheng ◽  
Li-Yu Lin ◽  
Chin Lin Hsu

2020 ◽  
pp. 27-30

The present study was designed to show the potential role of phenolic compounds against the toxicity of Burkholderia mallei. The study used 30 adult male rats that distributed to five groups (each group consist 6 rats); control group that received normal saline, second group rat injected intraperitoneal with B. mallei at dose 10 6 cell/ ml. third group rat injected intraperitoneal with B. mallei at dose 1 08 cell/ ml. fourth group rat injected intraperitoneal with B. mallei at dose 1 0 6 cell/ ml and treated with 250ug/ml of phenolic compounds for four weeks. Keywords—component, formatting, style, styling, insert (key words). Fifth group rat injected intraperitoneal with B. mallei at dose 1 08 cell/ ml and treated with 250ug/ml of phenolic compounds for four weeks. Sixth group rat treated with 250ug/ml of phenolic compounds for four weeks. The results show high significant increased (P < 0.05) in levels AST, ALT, ALP and MDA with high significant decreased (P < 0.05) in levels GSH, catalase in second and third groups compared with control group. The results of fourth, fifth and sixth groups show non-significant changes (P < 0.05) in all parameters compare with control group when using Rheum ribes. It was concluded that Rheum ribes has been potential role against the toxicity of B. mallei in adult male rats.


2019 ◽  
Vol 81 (2) ◽  
Author(s):  
Norashikin Mat Zain ◽  
Muhd Azlan Nazeri ◽  
Nurul Aini Azman

Over the years, a wide variety of natural colour sources have been identified. One source, the pitaya fruit is known to impart colours to products, such as food and drink. However, there have been limited studies done to determine phenolic compounds and antibacterial activity of the pitaya peel (H.polyrhizus) via Microwave Assisted Extraction (MAE) method. Both this information can escalate the potential role of pitaya fruit as a natural colour source. This study aimed to identify the types of bioactive compounds (phenolic compounds) and antibacterial activity of pitaya peel. To achieve this objective, MAE was used to extract bioactive compounds from the pitaya peel as it maintained the integrity of the compound. Based on the results, 13 types of phenolic compounds were identified from the pitaya peel extract via qualitative research using library database matching which include quinic acid, cinnamic acid, quinic acid isomer, 3,4-dihydroxyvinylbenzene, isorhamnetin 3-O-rutinoside, myricetin rhamno-hexoside, 3,30-di-O-methyl ellagic acid, isorhamnetin aglycone monomer, apigenin, jasmonic acid, oxooctadecanoic acid, 2 (3,4-dihydroxyphenyl)-7-hydroxy-5-benzene propanoic acid and protocatechuic hexoside conjugate.  The pitaya peel extract was also found to have small antibacterial effect on the Gram-positive, Staphylococcus aureus (S.aureus) and Gram- negative, Escherichia coli (E.coli). The SEM demonstrated that cell wall disruption of pitaya peel caused by microwave radiation from MAE appeared to be the main reason for rapid extraction of bioactive compounds. In conclusion, the study established that pitaya peel extract is a natural colour source with an abundance of phenolic compounds and minimal antibacterial activity, which could be used in the food and cosmetic industries. 


2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.


Sign in / Sign up

Export Citation Format

Share Document