A New Oleanane Triterpenoid from the Roots of Callerya speciosa

2020 ◽  
Vol 17 (5) ◽  
pp. 388-392
Author(s):  
Dao Duc Thien ◽  
Nguyen Thanh Tam ◽  
Nguyen Thi Hoang Anh ◽  
Dong Thi Kim Cuc ◽  
Nguyen Thi Thanh Mai ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
2D Nmr ◽  
Oleanane Triterpenoid

From the ethyl acetate extract of the roots of Callerya speciosa (Champ.) Schot. collected in Vietnam, a new oleanane triterpenoid, 22β-acetoxy-3β,24-dihydroxy-12-oleanen-30-oic acid (1), along with three known compounds, medicarpin (2), maackiain (3), and β-sitosterol (4), were obtained. The structure of the new compound was elucidated by HR-MS, 1D and 2D NMR experiments.

scholarly journals CONTRIBUTE TO STUDY ON CHEMICAL CONSTITUENTS OF URENA LOBATA (L.) OF VIETNAM

2019 ◽  
Vol 57 (2) ◽  
pp. 162
Author(s):  
Quan Minh Pham ◽  
Hoai Van Thi Tran ◽  
Lam Tien Do ◽  
Phuong Lan Doan ◽  
Inh Thi Cam ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Spectroscopic Methods ◽  
Tree Roots ◽  
Chemical Structures ◽  
Phytochemical Investigation ◽  
First Time

Urena lobata L. is used in Vietnamese traditional medicine for the treatment of several diseases. Tree roots are used to treat rheumatism, dysentery, poor digestion, flu, tonsils, malaria, asthma, goiter. Flowers are used to treat chickenpox, fever, and mental disorders. Branches, leaves or whole trees used to treat injuries bruises, rheumatism, mastitis, bites. Phytochemical investigation of the n-hexan and ethyl acetate extract of Urena lobata L. led to the isolation of β-sitosterol (1), β-sitosterol-3-O-β-D-glucopyranoside (2), a-acetylamino-phenylpropyl a-benzoylamino-phenylpropanoate (3), quercetin (4), and trans-tiliroside (5). Their chemical structures were determined by spectroscopic methods including MS, 1D, 2D NMR and comparing with those reported in previous papers. Two compounds 3, 5 were isolated for the first time from Urena lobata plant.

scholarly journals A NEW CYTOTOXIC DOLABELLANE FROM THE INDONESIAN SOFT CORAL Anthelia sp.

2013 ◽  
Vol 13 (3) ◽  
pp. 216-220 ◽  
Author(s):  
Anggia Murni ◽  
Novriyandi Hanif ◽  
Junichi Tanaka
Keyword(s):  
Mass Spectrometry ◽  
Drug Development ◽  
Ethyl Acetate ◽  
Spectroscopic Data ◽  
Soft Coral ◽  
Ethyl Acetate Extract ◽  
2D Nmr ◽  
Cancer Drug ◽  
Nmr Data ◽  
Anti Cancer

One new dolabellane (1) and two known diterpenoids stolonidiol (2) and clavinflol B (3) have been isolated from the ethyl acetate extract of the Indonesian soft coral Anthelia sp. A new compound 1 exhibited a moderate cytotoxicity against NBT-T2 cells at 10 µg/mL, while known compounds 2 and 3 showed cytotoxicity at 1 and 0.5 µg/mL, respectively. Structure of the new compound 1 was elucidated by interpretation of NMR spectroscopic data (1D and 2D NMR data) and mass spectrometry (ESIMS data) as well as comparison with those of related ones. This finding should be useful for anti cancer drug development of the promising dolabellane-types compound.

scholarly journals Four Flavan-3-ol Compounds From The Stembark of Chisocheton balansae C.DC. (MELIACEAE)

Molekul ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 9
Author(s):  
Unang Supratman ◽  
Mohamad Fajar ◽  
Supriatno Salam ◽  
Rani Maharani ◽  
Desi Harneti ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
13C Nmr ◽  
Chemical Structure ◽  
Ethyl Acetate Extract ◽  
2D Nmr ◽  
Stem Bark ◽  
Spectroscopic Methods ◽  
Endemic Plants ◽  
North Sulawesi ◽  
First Time

Chisocheton balansae C.DC., is one of the Meliaceae family plants which is the endemic plants from Soputan Mountain, North Sulawesi, Indonesia. This study was aimed to determine the chemical structure of flavan-3-ol compounds from ethyl acetate extract of C. balansae C.DC stembark. Dried powder of C. balansae C.DC stem bark was extracted consecutively with n-hexane, ethyl acetate, and methanol solvents. Four flavan-3-ol compounds, named catechin (1), epicatechin (2), epigallocatechin-3-O-gallate (3), and epicatechin-3-O-gallate (4) were successfully isolated from ethyl acetate extract. The chemical structure of these isolates was determined by spectroscopic methods (1H-NMR, 13C-NMR, DEPT, and 2D-NMR) and comparison with previous reported spectral data. These compounds are first time reported from this plant.

scholarly journals A Flavonoid Glycoside from the Leaves of Morinda Tinctoria

2008 ◽  
Vol 3 (9) ◽  
pp. 1934578X0800300
Author(s):  
Atish K. Sahoo ◽  
Nisha Narayanan ◽  
S. Rajan ◽  
Pulok K. Mukherjee
Keyword(s):  
Antioxidant Activity ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
First Record ◽  
2D Nmr ◽  
Flavonoid Glycoside ◽  
Dpph Scavenging ◽  
Dpph Scavenging Assay ◽  
Morinda Tinctoria

Tilianin (acacetine-7- O-β-D-glucopyranoside) was isolated from the ethyl acetate extract of Morinda tinctoria Roxb. and its structure established unambiguously by a series of 1D- and 2D-NMR analyses. This is the first record of this compound for this species. The antioxidant activity of tilianin, determined using the DPPH scavenging assay, was measured with an IC50 value of 57.5 μg/mL.

scholarly journals Protoflavanones from the Wood Stem of Salvertia convallariodora

2017 ◽  
Vol 12 (4) ◽  
pp. 1934578X1701200
Author(s):  
Mariana L. de Mesquita ◽  
José E. de Paula ◽  
Laila S. Espindola ◽  
Luiz A. L. Soares ◽  
Tania M. G. da Silva ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
2D Nmr ◽  
Phytochemical Analysis ◽  
Brazilian Cerrado ◽  
Stem Wood ◽  
Full Characterization ◽  
Glucosyl Ester ◽  
First Time

Phytochemical analysis of the ethyl acetate extract of stem wood of Salvertia convallariodora A. St.-Hil. (Vochysiaceae), a Brazilian Cerrado species, led to the isolation and full characterization of three new non-aromatic B-ring flavanones (1-3) as well as the terpene mixture of sericic acid (4), 24-hydroxytormentic acid (5), 24-hydroxytormentic acid glucosyl ester (6), and sericoside (7), all identified for the first time from S. convallariodora. The structures of the new flavanones (1-3) were established from IR, LC-PDA-qTOF-MS, and NMR spectral data, including 2D NMR experiments.

scholarly journals 4-ETOKSI-3-METOKSIFENOL DAN METIL-3,4-DIHIDROKSIBENZOAT, DUA SENYAWA TURUNAN FENOLIK DARI EKSTRAK ETIL ASETAT KULIT UMBI GADUNG (Dioscorea hispida Dennst) DAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETIL ASETAT

2018 ◽  
Vol 3 (1) ◽  
pp. 71
Author(s):  
Nanik Siti Aminah ◽  
Alfinda Novi Kristanti ◽  
Qonitah Labibah ◽  
Ana Firdausyah ◽  
Yoshiaki Takaya
Keyword(s):  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
2D Nmr ◽  
Free Radical Scavenging ◽  
Spectroscopic Methods ◽  
Separation And Purification ◽  
Activity Assay ◽  
Vacuum Liquid Chromatography

Two phenolic compoundnamely 4-ethoxy-3-methoxyphenol and methyl-3,4-dihydroxybenzoic have been isolated fromDioscorea hispida Dennst. The isolation of phenolic compounds was done by maceration methods using methanol, followed by partition with n-hexane and ethyl acetate. The process of separation and purification used various chromatography techniques including vacuum liquid chromatography, column chromatography, and radial chromatography. The structure of isolated compounds were determined by spectroscopic methods including UV-Vis, IR, 1D and 2D NMR. The ethyl acetate extract was evaluated for DPPH free radical scavenging activity assay. The IC50of ethyl acetate extract was 415 ppm. The result of this assay indicated that ethyl acetate extract has a potential as an antioxidant.  Keywords: Dioscorea hispida Dennst, Dioscoreaceae, phenolic, 4-ethoxy-3-methoxyphenol, methyl-3,4-dihydroxybenzoic, and antioxidant

scholarly journals ISOLASI KUMARIN DARI KULIT BUAH LIMAU SUNDAI (Citrus nobilis Lour)

2017 ◽  
Vol 18 (02) ◽  
pp. 137-145
Author(s):  
Melindra Mulia
Keyword(s):  
Melting Point ◽  
Ir Spectra ◽  
Ethyl Acetate ◽  
1H Nmr ◽  
Column Chromatography ◽  
13C Nmr ◽  
Ethyl Acetate Extract ◽  
2D Nmr ◽  
White Needle ◽  
Pure White

Coumarin has been isolated and characteritated from rind of  Citrus nobilis Lour by maseration methode with methanol. After fractionation by n-hexane and ethyl acetate, collected the phase ethyl acetate which positive of coumarin. From ethyl acetate extract coumarin have been isolated by column chromatography. The isolation results was obtain 2,159 g of pure white needle-shape crystalline with the melting point of 126,2-127,60C. Structure of the isolated coumarine was elucidated by spectroscopic methodes, UV-Vis,13C-NMR, 1H-NMR, 2D-NMR (DEPT/HSQC, COSY, NOESY, HMBC) and IR spectra. Based on the spectra data the isolated coumarine is marmin.

scholarly journals CONTRIBUTION TO THE STUDY ON CHEMICAL CONSTITUENTS OF HYDROCOTYLE VULGARIS (L.), APIACEAE

2009 ◽  
Vol 12 (10) ◽  
pp. 29-34
Author(s):  
Huong Nu Lien Ton ◽  
Phung Kim Phi Nguyen ◽  
Suong Ngoc Nguyen
Keyword(s):  
Essential Oil ◽  
Ethyl Acetate ◽  
Cancer Cells ◽  
Ethyl Acetate Extract ◽  
Chemical Constituents ◽  
2D Nmr ◽  
The One ◽  
Spectrum Data

The essential oil of Hydrocotyle vulgaris was analyzed by GC-MS then tested citotoxicity on the cancer cells. The result showed that the essential oil of Hydrocotyle vulgaris had weaker bioactities than the one of Hydrocotyle bonariensis, and in two species had the same main compounds. In addition, from the ethyl acetate extract, quercetin 3-O galactopyranoside was isolated and identified by the spectrum data 1D, 2D-NMR and MS.

scholarly journals (+)-Spectaline, a Piperidine Alkaloid from Senna spectabilis DC. Effective in Reducing the In Vitro Infection of Leishmania major

2016 ◽  
Vol 3 ◽  
pp. 1-8
Author(s):  
Amyra Amat Sain ◽  
Azimah Amanah ◽  
Zuriati Zahari ◽  
Roshan Jahn Mohd Salim ◽  
Sharif Mahsufi Mansor ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Leishmania Major ◽  
Ethyl Acetate Extract ◽  
Folk Medicine ◽  
2D Nmr ◽  
Selectivity Index ◽  
Antileishmanial Activity ◽  
Solvent Fractionation ◽  
Senna Spectabilis

Senna spectabilisis known to have antimicrobial, laxative, antiulcerogenic, analgesic, and anti-inflammatory properties in folk medicine. Piperidine alkaloids extracted from various parts of this plant have been shown to have anticonvulsant (iso-6-spectaline), antinociceptive [(-)-spectaline] and lipid peroxidation [(+)-3-O-feruloylcassine, (-)-spectaline and (-)-3-O-acetylspectaline] activities. In our study, the ethyl acetate extract fromS. spectabilisexhibited antileishmanial activity via intracellular promastigote assay or leishmanicidal assay and was further fractionated by using bioassay-guided isolation approach. The antiprotozoal principle was isolated from the ethyl acetate portion through solvent fractionation and a few series of chromatographic processes. The isolated active compound 1 was identified as (+)-spectaline on the basis of its spectral analysis (MS, 1D & 2D NMR) with EC50value of 0.063 ± 0.005 µM for antileishmanial activity and selectivity index of 3.76.

scholarly journals CHEMICAL CONSTITUENTS OF THE ETHYL ACETATE EXTRACT OF THE FRUIT BODIES OF PHELLINUS GILVUS

2018 ◽  
Vol 56 (4A) ◽  
pp. 246
Author(s):  
Quang Ngoc Dang
Keyword(s):  
Ethyl Acetate ◽  
National Park ◽  
Ethyl Acetate Extract ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Crystallographic Analysis ◽  
X Ray ◽  
Ergosterol Peroxide ◽  
Cytotoxicity Activities ◽  
Phellinus Gilvus

Five fungal secondary metabolites named 1,2,4,5-tetrachloro-3,6-dimethoxybenzene (1); ergosterol (2); ergosterol peroxide (3); (E)- 4-(3,4-dihydroxyphenyl)but-3-en-2-one (4) and [Bi-1,4-cyclohexandien-1-yl]-3,3’,6,6’-tetrone, 4, 4’-dihydroxyl-2,2’,5,5’-tetramethyl (5) were purified from ethyl acetate extract of the fruit bodies of Phellinus gilvus collected at Pu Mat national park, Nghe An province. Their structures were charaterized by 1D, 2D NMR and GC-MS spectroscopies. Especially, the structure of compound 1 was confirmed by X-ray crystallographic analysis. The antimicrobial and cytotoxicity activities of compounds 1 were also evaluated. This is the first report on the chemical constituents of Vietnamese Phellinus gilvus.

Sign in / Sign up

Export Citation Format

Share Document