Potential New Therapeutic Options for Involvement of Central Nervous System in Behcets Disease (Neuro-Behcets Syndrome)

2007 ◽  
Vol 3 (4) ◽  
pp. 297-303 ◽  
Author(s):  
Shunsei Hirohata
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Therapeutic Options

scholarly journals The Cuprizone Model: Dos and Do Nots

Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 843 ◽  
Author(s):  
Jiangshan Zhan ◽  
Teresa Mann ◽  
Sarah Joost ◽  
Newshan Behrangi ◽  
Marcus Frank ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Demyelinating Disease ◽  
Therapeutic Options ◽  
Practical Guide ◽  
Clinical Models ◽  
The Central Nervous System ◽  
Ms Pathogenesis

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Various pre-clinical models with different specific features of the disease are available to study MS pathogenesis and to develop new therapeutic options. During the last decade, the model of toxic demyelination induced by cuprizone has become more and more popular, and it has contributed substantially to our understanding of distinct yet important aspects of the MS pathology. Here, we aim to provide a practical guide on how to use the cuprizone model and which pitfalls should be avoided.

Neurotropic enteroviruses co-opt “fair-weather-friend” commensal gut microbiota to drive host infection and central nervous system disturbances

2019 ◽  
Vol 42 ◽  
Author(s):  
Kevin B. Clark
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gut Bacteria ◽  
Infection Cycle ◽  
Fair Weather ◽  
Host Health ◽  
Microbe Interactions ◽  
Animal Hosts ◽  
Host Infection ◽  
Neuropsychiatric Conditions

Abstract Some neurotropic enteroviruses hijack Trojan horse/raft commensal gut bacteria to render devastating biomimicking cryptic attacks on human/animal hosts. Such virus-microbe interactions manipulate hosts’ gut-brain axes with accompanying infection-cycle-optimizing central nervous system (CNS) disturbances, including severe neurodevelopmental, neuromotor, and neuropsychiatric conditions. Co-opted bacteria thus indirectly influence host health, development, behavior, and mind as possible “fair-weather-friend” symbionts, switching from commensal to context-dependent pathogen-like strategies benefiting gut-bacteria fitness.

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