Biomimetic copper oxide nanoparticles and its validation through in-silico approach on cardiac enzymes

2021 ◽  
Vol 16 ◽  
Author(s):  
Jacquline Rosy P ◽  
VenkatKumar Shanmugam ◽  
Jebastin Sonia Jas ◽  
Santhoshkumar Jayakodi
Keyword(s):  
Electron Microscopy ◽  
Copper Oxide ◽  
In Silico ◽  
Active Sites ◽  
Computational Analysis ◽  
Cuo Nanoparticles ◽  
Oxide Nanoparticles ◽  
Cardiac Enzymes ◽  
Hydrogen Bond Interaction ◽  
Cardioprotective Effects

Background: The present study outlines the green synthesis of copper oxide (GS-CuO) nanoparticles using Magnolia champaca plant floral extract for the first time. Computational analysis showed the role of GS-CuO nanoparticles on cardiac enzymes ACE2 and SOD1 functional expression through hydrogen bond interaction with amino acid residues. Method: The synthesized GS-CuO nanoparticles were characterized by various techniques like X-Ray Diffraction, UVVis Spectrophotometer, Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy and Transmission Electron Microscopy. Results: Nanoparticles demonstrate the presence of spherical shape and size 20 nm. The particles have many active sites and as compared to the bulk materials, and thus, the computational analysis was conducted against angiotensin-converting enzyme and superoxide dismutase to visualize the cardioprotective effects. Conclusion: The in-silico approach established valuable information on cardioprotective effects of green synthesized oxide nanoparticles using Magnolia champaca.

scholarly journals Aqueous Extract of Saraca indica Leaves in the Synthesis of Copper Oxide Nanoparticles: Finding a Way towards Going Green

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Kollur Shiva Prasad ◽  
Alakananda Patra ◽  
Govindaraju Shruthi ◽  
Shivamallu Chandan
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Copper Oxide ◽  
Aqueous Extract ◽  
Copper Oxide Nanoparticles ◽  
Cuo Nanoparticles ◽  
Oxide Nanoparticles ◽  
X Ray ◽  
Transmission Electron ◽  
Varied Size

The present study is mainly aimed at the synthesis of copper oxide nanoparticles of varied size by green synthetic approach. The structural and morphological behavior of as-synthesized CuO nanoparticles were investigated using ultraviolet-visible spectral studies (UV-Vis), Fourier transform-Infrared spectroscopy (FT-IR), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and high-resolution transmission electron microscopy (HRTEM). The reduction of copper ions using aqueous extract of S. indica leaves produces nanoparticles of varied size and morphology. The images from SEM investigation revealed that the particles are spherical in shape with average diameter of 40–70 nm. TEM and HRTEM images clearly indicate the crystallinity and spherical nature of as-synthesized CuO nanoparticles with interplanar distance between two neighboring lattice fringes of 0.315 nm.

scholarly journals Green Synthesis, Characterization and Antibacterial Activity of Copper Oxide Nanoparticles Using Annona muricata Stem Extract

2021 ◽  
Vol 9 (12) ◽  
pp. 1205-1214
Author(s):  
Shivani Kushwaha
Keyword(s):  
Antibacterial Activity ◽  
Copper Oxide ◽  
Copper Sulphate ◽  
Copper Oxide Nanoparticles ◽  
Maximum Activity ◽  
Cuo Nanoparticles ◽  
Oxide Nanoparticles ◽  
Gradual Change ◽  
Annona Muricata ◽  
Stem Extract

Abstract: Nanotechnology is a rising field of science and technology that deals with the particles having size in the range of 1 to 100 nm. Copper oxide nanoparticles has many properties like antifungal activity, antibacterial activity, optical properties, conductive properties, etc. Due to its demand of diversified use, copper oxide nanoparticles were fabricated using ecofriendly and non-toxic Annona muricata stem extract. The extract with copper sulphate pentahydrate showed gradual change in the colour of the extract from brown to green which indicates the CuO nanoparticles synthesis. The fabrication is followed by characterization of CuO nanoparticles using UV-vis spectroscope, FTIR, XRD and SEM. The characterization showed roughly spherical shaped nanoparticles in the range of 100nm with high crystalline monoclinic phase. FTIR absorption spectra conclude that the compounds attached with copper oxide nanoparticles could be polyphenols with aromatic ring. The CuO nanoparticles exhibited antibacterial activity; it showed the maximum activity against E.coli (18 mm). Keywords: Annona muricata, copper sulphate pentahydrate, FTIR, nanomaterials, SEM, XRD.

scholarly journals Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells

2016 ◽  
Vol 3 (2) ◽  
pp. 365-374 ◽  
Author(s):  
Amaraporn Wongrakpanich ◽  
Imali A. Mudunkotuwa ◽  
Sean M. Geary ◽  
Angie S. Morris ◽  
Kranti A. Mapuskar ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Copper Oxide ◽  
Copper Oxide Nanoparticles ◽  
Cuo Nanoparticles ◽  
Lung Epithelial Cells ◽  
Oxide Nanoparticles ◽  
Size Dependent ◽  
Lung Epithelial

The increasing use of copper oxide (CuO) nanoparticles (NPs) in medicine and industry demands an understanding of their potential toxicities.

A cyano-bridged copper(ii)–copper(i) mixed-valence coordination polymer as a source of copper oxide nanoparticles with catalytic activity in C–N, C–O and C–S cross-coupling reactions

2014 ◽  
Vol 38 (9) ◽  
pp. 4267-4274 ◽  
Author(s):  
Manoj Trivedi ◽  
Sanjeev kumar Ujjain ◽  
Raj Kishore Sharma ◽  
Gurmeet Singh ◽  
Abhinav Kumar ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Coordination Polymer ◽  
Copper Oxide ◽  
Mixed Valence ◽  
Cross Coupling ◽  
Copper Oxide Nanoparticles ◽  
Cuo Nanoparticles ◽  
Oxide Nanoparticles ◽  
Coupling Reactions ◽  
Cross Coupling Reactions

A cyano-bridged Cu(ii)–Cu(i) complex was synthesized and transformed into CuO nanoparticles. Their catalytic activity in C–N, C–O, and C–S cross-coupling reactions was explored.

Preparation of a colloidal photonic crystal containing CuO nanoparticles with tunable structural colors

RSC Advances ◽  
2015 ◽  
Vol 5 (127) ◽  
pp. 105200-105205 ◽  
Author(s):  
Chun-Feng Lai ◽  
Yu-Chi Wang ◽  
Chia-Lung Wu ◽  
Jia-Yu Zeng ◽  
Chia-Feng Lin
Keyword(s):  
Photonic Crystal ◽  
Copper Oxide ◽  
Crystal Structures ◽  
Copper Oxide Nanoparticles ◽  
Cuo Nanoparticles ◽  
Oxide Nanoparticles ◽  
Structural Colors

Polystyrene colloidal photonic crystal structures containing copper oxide nanoparticles present tunable structural colors, which are highly useful properties for applications.

Synthesis & Study of Nano Size Copper Oxide Particle via Chemical Method

2013 ◽  
Vol 829 ◽  
pp. 187-191
Author(s):  
Maryam Abdolhosseinzadeh ◽  
Niloofar Khodamoradi
Keyword(s):  
Electron Microscopy ◽  
Copper Oxide ◽  
Oxide Particle ◽  
Copper Oxide Nanoparticles ◽  
Cuo Nanoparticles ◽  
Molar Ratio ◽  
Transmission Electron ◽  
Uv Visible ◽  
Micro Reactors ◽  
Nano Size

Copper oxide nanoparticles have been synthesized using micro reactors made of bis (2-ethylhexyle) sulfosuccinate (AOT)/water/n-Hexane microemulsions. The controls of particles size was achieved by varying water to surfactant molar ratio (W0). At constant of surfactant concentration the increases in value of W0increased the population of micelles and resulted in lager particle size. Their sizes and appearance were characterized by TEM, SEM, Zetasizer, uv-visible methods. Scanning electron microscopy (SEM) showed the spherical morphology of as prepared CuO nanoparticles. The Transmission electron microscopy (TEM) showed 85 nm size of as prepared CuO particles.

Sulfidation of copper oxide nanoparticles and properties of resulting copper sulfide

2014 ◽  
Vol 1 (4) ◽  
pp. 347-357 ◽  
Author(s):  
Rui Ma ◽  
John Stegemeier ◽  
Clément Levard ◽  
James G. Dale ◽  
Clinton W. Noack ◽  
...  
Keyword(s):  
Copper Oxide ◽  
Copper Sulfide ◽  
Copper Oxide Nanoparticles ◽  
Cuo Nanoparticles ◽  
Oxide Nanoparticles ◽  
Apparent Solubility

Sulfidation of 40 nm CuO nanoparticles in water yields poorly structured CuxSyand crystalline covellite (CuS) with increasing apparent solubility.

scholarly journals Copper oxide nanoparticles synthesis and characterization using UV-vis spectrophotometer and TEM

2019 ◽  
Vol 10 (4) ◽  
pp. 2845-2848
Author(s):  
Sadhvi B ◽  
Rajeshkumar S ◽  
Anitha Roy ◽  
Lakshmi T
Keyword(s):  
Copper Oxide ◽  
Plant Extract ◽  
Spherical Shape ◽  
Copper Oxide Nanoparticles ◽  
Cuo Nanoparticles ◽  
Synthesis And Characterization ◽  
Oxide Nanoparticles ◽  
Medical Field ◽  
Cost Efficient

To synthesise Copper oxide nanoparticles and study it's characterisation using UV -viz - Spectrophotometer and TEM.  Copper oxide nanoparticles are eco-friendly, cost-efficient and diverse utilisation all over the medical field. The shape of the CuO nanoparticles are spherical, and its characterisation is done using SEM, TEM, and UV-vis techniques. The size of the nanoparticles mediated in each plant extract differs from one another. MATERIALS AND METHODS  * Collection and Preparation of Plant extracts. * Synthesis Of CuONPs * Characterization of copper nanoparticles * preparation of nanoparticles powder. The plant extract is in green colour, and the CuO nanoparticles are seen in light yellowish in colour. Uv-VIS SPECTROMETER:  The particle size ranges from 2-100nm and shape is spherical. The graph reached its peak at the wavelength of 300nm. The TEM shows spherical shape, dispersion and versatile nanoparticles. They appear to be arranged in a cluster, open and quasi-linear superstructures. This research shows that CuO nanoparticles shows excellent biocompatibility. The particles which are smaller in size shows great immunity. Hence the nanoparticles are expected to be used in future for effective drug systems.

scholarly journals Self-grafting copper oxide nanoparticles show a strong enhancement of their anti-algal and anti-yeast action

2019 ◽  
Vol 1 (6) ◽  
pp. 2323-2336 ◽  
Author(s):  
Ahmed F. Halbus ◽  
Tommy S. Horozov ◽  
Vesselin N. Paunov
Keyword(s):  
Copper Oxide ◽  
Functional Groups ◽  
Cell Membranes ◽  
Covalent Binding ◽  
Copper Oxide Nanoparticles ◽  
Cuo Nanoparticles ◽  
Oxide Nanoparticles ◽  
Strong Enhancement

We report a strong amplification of the anti-algal and anti-yeast action of CuO nanoparticles surface-grafted with 4-hydroxyphenylboronic acid functional groups due to their covalent binding to carbohydrates on the cell membranes.

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