Green Synthesis, Characterization and Antibacterial Activity of Copper Oxide Nanoparticles Using Annona muricata Stem Extract

Abstract: Nanotechnology is a rising field of science and technology that deals with the particles having size in the range of 1 to 100 nm. Copper oxide nanoparticles has many properties like antifungal activity, antibacterial activity, optical properties, conductive properties, etc. Due to its demand of diversified use, copper oxide nanoparticles were fabricated using ecofriendly and non-toxic Annona muricata stem extract. The extract with copper sulphate pentahydrate showed gradual change in the colour of the extract from brown to green which indicates the CuO nanoparticles synthesis. The fabrication is followed by characterization of CuO nanoparticles using UV-vis spectroscope, FTIR, XRD and SEM. The characterization showed roughly spherical shaped nanoparticles in the range of 100nm with high crystalline monoclinic phase. FTIR absorption spectra conclude that the compounds attached with copper oxide nanoparticles could be polyphenols with aromatic ring. The CuO nanoparticles exhibited antibacterial activity; it showed the maximum activity against E.coli (18 mm). Keywords: Annona muricata, copper sulphate pentahydrate, FTIR, nanomaterials, SEM, XRD.

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ANTIBIOTIC PROFILE AND ANTIBACTERIAL ACTIVITY OF COPPER OXIDE NANOPARTICLES AGAINST Pseudomonas fluorescens ISOLATED FROM WOUND INFECTION

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v9i3.10 ◽

2019 ◽

Vol 9 (o3) ◽

Author(s):

Haider Qassim Raheem ◽

Takwa S. Al-meamar ◽

Anas M. Almamoori

Keyword(s):

Antibacterial Activity ◽

Copper Oxide ◽

Pseudomonas Fluorescens ◽

Wide Spectrum ◽

Copper Oxide Nanoparticles ◽

Morphological Properties ◽

Clinical Samples ◽

Oxide Nanoparticles ◽

Cuo Nps ◽

Disk Diffusion Assay

Fifty specimens were collected from wound patients who visited Al-Hilla Teaching Hospital. The samples were grown on Blood and MacConkey agar for 24-48 hr at 37oC. The bacterial isolates which achieved as a pure and predominant growth from clinical samples as Pseudomonas fluorescens, were identified using morphological properties and Vitek2 system. The anti-bacterial activity of copper oxide nanoparticles (CuO NPs) against was tested by (disk diffusion assay) using dilutions of (400, 200, 100, 50, 25, and 12.5‎µ‎g/ml). The (MIC and MBC) of each isolate was determined. CuO NPs shows wide spectrum antibacterial activity against tested bacteria with rise zone of inhibition diameter that is proportionate with the increase in nanoparticle concentration. The MIC of CuO NPs extended from 100-200‎µ‎g/ml and the MBC ranged from 200-400‎µ‎g/ml. The antibiotic profile was determined by Viteck 2 compact system (Biomérieux). CuO NPs‎ found highly effective and safe in P. fluorescens wounds infections comparing with used antibiotics.

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Green synthesis of copper oxide nanoparticles using Cedrus deodara aqueous extract for antibacterial activity

Materials Today Proceedings ◽

10.1016/j.matpr.2020.05.472 ◽

2020 ◽

Author(s):

M. Ramzan ◽

Raphael.M. Obodo ◽

S. Mukhtar ◽

S.Z. Ilyas ◽

Fahad Aziz ◽

...

Keyword(s):

Antibacterial Activity ◽

Copper Oxide ◽

Green Synthesis ◽

Aqueous Extract ◽

Copper Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Cedrus Deodara

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Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells

Environmental Science Nano ◽

10.1039/c5en00271k ◽

2016 ◽

Vol 3 (2) ◽

pp. 365-374 ◽

Cited By ~ 24

Author(s):

Amaraporn Wongrakpanich ◽

Imali A. Mudunkotuwa ◽

Sean M. Geary ◽

Angie S. Morris ◽

Kranti A. Mapuskar ◽

...

Keyword(s):

Epithelial Cells ◽

Copper Oxide ◽

Copper Oxide Nanoparticles ◽

Cuo Nanoparticles ◽

Lung Epithelial Cells ◽

Oxide Nanoparticles ◽

Size Dependent ◽

Lung Epithelial

The increasing use of copper oxide (CuO) nanoparticles (NPs) in medicine and industry demands an understanding of their potential toxicities.

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A cyano-bridged copper(ii)–copper(i) mixed-valence coordination polymer as a source of copper oxide nanoparticles with catalytic activity in C–N, C–O and C–S cross-coupling reactions

New Journal of Chemistry ◽

10.1039/c4nj00829d ◽

2014 ◽

Vol 38 (9) ◽

pp. 4267-4274 ◽

Cited By ~ 7

Author(s):

Manoj Trivedi ◽

Sanjeev kumar Ujjain ◽

Raj Kishore Sharma ◽

Gurmeet Singh ◽

Abhinav Kumar ◽

...

Keyword(s):

Catalytic Activity ◽

Coordination Polymer ◽

Copper Oxide ◽

Mixed Valence ◽

Cross Coupling ◽

Copper Oxide Nanoparticles ◽

Cuo Nanoparticles ◽

Oxide Nanoparticles ◽

Coupling Reactions ◽

Cross Coupling Reactions

A cyano-bridged Cu(ii)–Cu(i) complex was synthesized and transformed into CuO nanoparticles. Their catalytic activity in C–N, C–O, and C–S cross-coupling reactions was explored.

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Green synthesis of copper oxide nanoparticles and its effective applications in Biginelli reaction, BTB photodegradation and antibacterial activity

Advanced Powder Technology ◽

10.1016/j.apt.2018.09.009 ◽

2018 ◽

Vol 29 (12) ◽

pp. 3315-3326 ◽

Cited By ~ 21

Author(s):

Shanmugam Prakash ◽

Nagaraj Elavarasan ◽

Alagesan Venkatesan ◽

Kasivisvanathan Subashini ◽

Murugesan Sowndharya ◽

...

Keyword(s):

Antibacterial Activity ◽

Copper Oxide ◽

Green Synthesis ◽

Biginelli Reaction ◽

Copper Oxide Nanoparticles ◽

Oxide Nanoparticles

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Preparation of a colloidal photonic crystal containing CuO nanoparticles with tunable structural colors

RSC Advances ◽

10.1039/c5ra21035f ◽

2015 ◽

Vol 5 (127) ◽

pp. 105200-105205 ◽

Cited By ~ 5

Author(s):

Chun-Feng Lai ◽

Yu-Chi Wang ◽

Chia-Lung Wu ◽

Jia-Yu Zeng ◽

Chia-Feng Lin

Keyword(s):

Photonic Crystal ◽

Copper Oxide ◽

Crystal Structures ◽

Copper Oxide Nanoparticles ◽

Cuo Nanoparticles ◽

Oxide Nanoparticles ◽

Structural Colors

Polystyrene colloidal photonic crystal structures containing copper oxide nanoparticles present tunable structural colors, which are highly useful properties for applications.

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