The anti-osteoporosis effects of Vitamin K in postmenopausal women

Abstract: As a common systemically muscular-skeleton disorder in aging, osteoporosis is characterized by the uninterrupted deconstruction in osseous microarchitecture. Osteoporosis can consequently lead to a significantly high risk of osteoporotic fractures, such as osteoporotic vertebral compressive fractures [OVCF] in the spine and osteoporotic femoral neck fractures, which can significantly increase the numbers of mortality and morbidity in aging people, especially in postmenopausal women. In addition, vitamin K has been demonstrated to play a key role in inhibiting osteoporotic fractures among postmenopausal women, but its long-term benefits, potential harms, and effects of the combination between vitamin K and other anti-osteoporosis medicines such as bisphosphonates or teriparatide were just extensively studied. Therefore, the present review aimed to systematically reviewed published literature on the role of vitamin K in the treatment of osteoporosis. We currently, via multiple queries strategy, searched the relevant literature in Cochrane and PubMed from January 2010 to December 2019. Subsequently, we conducteda systematic review according to the standard guideline of Preferred Reporting Item for Systematic Reviews and Meta-Analyses [PRISMA]. Finally, ten relevant works of literature met our current criteria for inclusion, and then we followed the PRISMA guideline and systematically reviewed each study by the categorized data sources and analytical approaches in each study, meanwhile set up variables and defined each study outcomes.

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Patient Scheduling — (Bibliography)

Methods of Information in Medicine ◽

10.1055/s-0038-1636579 ◽

1977 ◽

Vol 16 (02) ◽

pp. 112-115 ◽

Cited By ~ 2

Author(s):

C. O. Köhler ◽

G. Wagner ◽

U. Wolber

Keyword(s):

Information Processing ◽

Medical Care ◽

Medical Informatics ◽

Relevant Literature ◽

Patient Scheduling ◽

Individual Scientist ◽

Set Up ◽

The Individual ◽

New Literature ◽

Current Systems

The entire field of information processing in medicine is today already spread out and branched to such an extent that it is no longer possible to set up a survey on relevant literature as a whole. But even in narrow parts of medical informatics it is hardly possible for the individual scientist to keep up to date with new literature. Strictly defined special bibliographies on certain topics are most helpful.In our days, problems of optimal patient scheduling and exploitation of resources are gaining more and more importance. Scientists are working on the solution of these problems in many places.The bibliography on »Patient Scheduling« presented here contains but a few basic theoretical papers on the problem of waiting queues which are of importance in the area of medical care. Most of the papers cited are concerned with practical approaches to a solution and describe current systems in medicine.In listing the literature, we were assisted by Mrs. Wieland, Mr. Dusberger and Mr. Henn, in data acquisition and computer handling by Mrs. Gieß and Mr. Schlaefer. We wish to thank all those mentioned for their assistance.

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Multidisciplinary team management of 46,XY 17α-hydroxylase deficiency: a case report and literature review

Journal of International Medical Research ◽

10.1177/0300060521993965 ◽

2021 ◽

Vol 49 (3) ◽

pp. 030006052199396

Author(s):

Yang Zhou ◽

Xue Xue ◽

Panpan Shi ◽

Qinrui Lu ◽

Shulan Lv

Keyword(s):

Multidisciplinary Team ◽

Relevant Literature ◽

Management Plan ◽

Laboratory Evaluation ◽

Primary Amenorrhea ◽

Physical And Mental Health ◽

Hydroxylase Deficiency ◽

Holistic Management ◽

Sexual Characteristics ◽

Set Up

Background We report here a case study of 17α-hydroxylase deficiency in a phenotypic girl with male karyotype (46,XY). We also review the relevant literature to deepen our understanding of the disease, reduce the rate of missed diagnosis, and emphasize that holistic management of this disease requires collaborative multidisciplinary teamwork. Case presentation A 14-year-old patient with a female phenotype visited the endocrinology department because of hypertension. The patient had primary amenorrhea and lacked secondary sexual characteristics. Initial laboratory evaluation revealed normal levels of electrolytes, a hypergonadotropic hypogonadal state with high progesterone and low testosterone levels, and a 46,XY karyotype. She was referred to the urology department for gonadectomy and transferred to the gynecological endocrine clinic. On the basis of the patient’s medical history and genetic testing results, a diagnosis of 46,XY 17α-hydroxylase deficiency was made. The patient was provided with glucocorticoids, estrogens, metformin, and psychological support. Conclusions Patients with 17α-hydroxylase deficiency, a rare cause of congenital adrenal hyperplasia, should be treated by a multidisciplinary team. Relevant experts from different disciplines should set up a systematic and comprehensive individualized management plan to optimize the physical and mental health and quality of life of affected patients.

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Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications

Bone Research ◽

10.1038/s41413-021-00143-3 ◽

2021 ◽

Vol 9 (1) ◽

Author(s):

Xiaowei Zhu ◽

Weiyang Bai ◽

Houfeng Zheng

Keyword(s):

Drug Targets ◽

Complex Disease ◽

Association Studies ◽

Osteoporotic Fractures ◽

Disease Prediction ◽

Genome Wide Association Studies ◽

Mineral Density ◽

Small Effect Size ◽

Endocrine Status ◽

Meta Analyses

AbstractOsteoporosis is a common skeletal disease, affecting ~200 million people around the world. As a complex disease, osteoporosis is influenced by many factors, including diet (e.g. calcium and protein intake), physical activity, endocrine status, coexisting diseases and genetic factors. In this review, we first summarize the discovery from genome-wide association studies (GWASs) in the bone field in the last 12 years. To date, GWASs and meta-analyses have discovered hundreds of loci that are associated with bone mineral density (BMD), osteoporosis, and osteoporotic fractures. However, the GWAS approach has sometimes been criticized because of the small effect size of the discovered variants and the mystery of missing heritability, these two questions could be partially explained by the newly raised conceptual models, such as omnigenic model and natural selection. Finally, we introduce the clinical use of GWAS findings in the bone field, such as the identification of causal clinical risk factors, the development of drug targets and disease prediction. Despite the fruitful GWAS discoveries in the bone field, most of these GWAS participants were of European descent, and more genetic studies should be carried out in other ethnic populations to benefit disease prediction in the corresponding population.

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POS7 COST-EFFECTIVENESS OF TERIPARATIDE (FORTEO) IN THE PREVENTION OF OSTEOPOROTIC FRACTURES AMONG MEN AND POSTMENOPAUSAL WOMEN IN AUSTRALIA

Value in Health ◽

10.1016/s1098-3015(10)62304-2 ◽

2004 ◽

Vol 7 (3) ◽

pp. 297 ◽

Cited By ~ 1

Author(s):

PL Graham-Clarke ◽

M Lees ◽

T Wolthers ◽

D Thiebaud ◽

N Price

Keyword(s):

Cost Effectiveness ◽

Postmenopausal Women ◽

Osteoporotic Fractures

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Lifetime and Five-Year Age-Specific Risks of First and Subsequent Osteoporotic Fractures in Postmenopausal Women

Osteoporosis International ◽

10.1007/s001980170152 ◽

2001 ◽

Vol 12 (1) ◽

pp. 16-23 ◽

Cited By ~ 69

Author(s):

D. A. Doherty ◽

K. M. Sanders ◽

M. A. Kotowicz ◽

R. L Prince

Keyword(s):

Postmenopausal Women ◽

Osteoporotic Fractures

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Pre-NELA vs NELA – has anything changed, or is it just an audit exercise?

Annals of The Royal College of Surgeons of England ◽

10.1308/rcsann.2016.0248 ◽

2016 ◽

Vol 98 (8) ◽

pp. 554-559 ◽

Cited By ~ 3

Author(s):

M Mak ◽

AR Hakeem ◽

V Chitre

Keyword(s):

Critical Care ◽

High Risk ◽

Uneventful Recovery ◽

Emergency Laparotomy ◽

Mortality And Morbidity ◽

High Risk Patients ◽

Possum Score ◽

Operative Severity Score ◽

Risk Patients ◽

Set Up

BACKGROUND Following evidence suggestive of high mortality following emergency laparotomies, the National Emergency Laparotomy Audit (NELA) was set up, highlighting key standards in emergency service provision. Our aim was to compare our NHS trust’s adherence to these recommendations immediately prior to, and following, the launch of NELA, and to compare patient outcome. METHODS This was a retrospective study of patients who underwent an emergency laparotomy over the course of 6 months – 3 months either side of the initiation of NELA. RESULTS There were 44 patients before the initiation of NELA (pre-NELA, PN group) and 55 in the first 3 months of NELA (N group). We saw a significant increase in the proportion of patients whose decision to operate was made by the consultant: 75.0% in the PN group vs 100% in N group (subsequent data presented in this order) (P < 0.001). The presence of a consultant surgeon (75.0% vs 83.6%, P = 0.321) and anaesthetist (100.0% vs 90.9%, P = 0.064) in theatres were comparable in both groups. Risk stratification based on Portsmouth Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (P-POSSUM) score showed no difference in high-risk patients in both groups (47.7% vs 36.4%, P = 0.306). With the NELA initiative, however, significantly more patients were admitted directly from theatres to the critical care unit, when compared with the pre-NELA period (9.1% vs 27.3%, P = 0.038). This also reflected a significant reduction in unexpected escalation to a higher level of care during this period (10.0% vs 0%, P = 0.036). Significantly more patients had uneventful recovery in the NELA period (52.3 vs 76.4%, P = 0.018), although there was no difference in 30-day mortality between the groups (2.3% vs 7.3%, P = 0.378). CONCLUSIONS This study demonstrated a greater degree of consultant involvement in the decision to operate during NELA. More high-risk patients have been identified preoperatively with diligent risk assessment and, hence, have been proactively admitted to critical care units following laparotomy, which may account for the significant reduction in unexpected escalation to level 2 or level 3 care and thus in overall better patient outcomes.

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