Lifetime and Five-Year Age-Specific Risks of First and Subsequent Osteoporotic Fractures in Postmenopausal Women

Abstract: As a common systemically muscular-skeleton disorder in aging, osteoporosis is characterized by the uninterrupted deconstruction in osseous microarchitecture. Osteoporosis can consequently lead to a significantly high risk of osteoporotic fractures, such as osteoporotic vertebral compressive fractures [OVCF] in the spine and osteoporotic femoral neck fractures, which can significantly increase the numbers of mortality and morbidity in aging people, especially in postmenopausal women. In addition, vitamin K has been demonstrated to play a key role in inhibiting osteoporotic fractures among postmenopausal women, but its long-term benefits, potential harms, and effects of the combination between vitamin K and other anti-osteoporosis medicines such as bisphosphonates or teriparatide were just extensively studied. Therefore, the present review aimed to systematically reviewed published literature on the role of vitamin K in the treatment of osteoporosis. We currently, via multiple queries strategy, searched the relevant literature in Cochrane and PubMed from January 2010 to December 2019. Subsequently, we conducteda systematic review according to the standard guideline of Preferred Reporting Item for Systematic Reviews and Meta-Analyses [PRISMA]. Finally, ten relevant works of literature met our current criteria for inclusion, and then we followed the PRISMA guideline and systematically reviewed each study by the categorized data sources and analytical approaches in each study, meanwhile set up variables and defined each study outcomes.

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THE UTILITY OF TBS-ADJUSTED BMD T-SCORE IN THE DISCRIMINATION OF THE MAJOR OSTEOPOROTIC FRACTURES IN THE POSTMENOPAUSAL WOMEN OF THE ROTTERDAM AND THE OSTEOLAUS STUDIES

Journal of Clinical Densitometry ◽

10.1016/j.jocd.2018.05.034 ◽

2018 ◽

Vol 21 (4) ◽

pp. 610

Author(s):

Enisa Shevroja ◽

Fjorda Koromani ◽

William D. Leslie ◽

Olivier Lamy ◽

Fernando Rivadeneira ◽

...

Keyword(s):

Postmenopausal Women ◽

Osteoporotic Fractures ◽

T Score ◽

Major Osteoporotic Fractures

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Does Bone Mineral Apparent Density Predict Osteoporotic Fractures in Lebanese Postmenopausal Women?

Journal of Clinical Densitometry ◽

10.1016/j.jocd.2014.04.088 ◽

2014 ◽

Vol 17 (3) ◽

pp. 423

Author(s):

R. El Hage ◽

A. Sebaaly ◽

M. Issa ◽

F. Bachour ◽

E. Zakhem ◽

...

Keyword(s):

Postmenopausal Women ◽

Bone Mineral ◽

Apparent Density ◽

Osteoporotic Fractures ◽

Bone Mineral Apparent Density

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Association Between moleculars and Osteoporotic Fracture Risk:A systematical review

10.1101/2020.03.31.20049429 ◽

2020 ◽

Author(s):

Jie-Yu Liu ◽

Jia-Xiang Wang ◽

Li Xu ◽

Shu-Feng Lei ◽

Fei-Yan Deng

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Elderly Population ◽

Early Recognition ◽

Osteoporotic Fractures ◽

Middle Aged ◽

Mineral Density ◽

Low Bone Mineral Density ◽

Increased Risk

AbstractOsteoporosis is a systemic chronic skeletal disease, which is characterized by low bone mineral density (BMD) and increased risk to osteoporotic fractures (OFs). OFs are associated with high mortality and morbidity, and seriously affect the life quality of patients. Osteoporosis is prevalent in the middle-aged and elderly population, especially the postmenopausal women. With population aging, osteoporosis becomes a world-wide serious public health problem. Early recognition of the high-risk population followed by timely and efficient intervention and/or treatment is important for preventing OFs. In light of the high heritability and complex pathogenesis of OP, comprehensive consideration of significant biological/biochemical factors is necessary for accurate risk evaluation. For this purpose, we reviewed recent research progress on moleculars which are diagnostic and/or predictive of OFs risk. Future integrative analyses and systematic evaluation of these moleculars may facilitate developing novel methodologies and/or test strategies, i.e., biochips, for early recognition of osteoporosis, hence to contribute to preventing OFs in the world.Graphical AbstractOsteoporosis, which is characterized by low bone mineral density (BMD) and increased risk to osteoporotic fractures (OFs), is prevalent in the middle-aged and elderly population, especially in the postmenopausal women. We focused on several types of important molecules, including proteins/peptides, RNAs, lipids, to gain comprehensive understanding and to generate novel perspectives in predicting and diagnosing OFs.

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Correction to: The association of urinary pentosidine levels with the prevalence of osteoporotic fractures in postmenopausal women

Journal of Bone and Mineral Metabolism ◽

10.1007/s00774-019-01056-2 ◽

2019 ◽

Vol 38 (2) ◽

pp. 275-275

Author(s):

Masataka Shiraki ◽

Shoji Kashiwabara ◽

Takumi Imai ◽

Shiro Tanaka ◽

Mitsuru Saito

Keyword(s):

Postmenopausal Women ◽

Osteoporotic Fractures

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Expression of microRNAs that regulate bone turnover in the serum of postmenopausal women with low bone mass and vertebral fractures

Acta Endocrinologica ◽

10.1530/eje-16-0583 ◽

2017 ◽

Vol 176 (2) ◽

pp. 169-176 ◽

Cited By ~ 43

Author(s):

Maria P Yavropoulou ◽

Athanasios D Anastasilakis ◽

Polyzois Makras ◽

Dimitrios G Tsalikakis ◽

Maria Grammatiki ◽

...

Keyword(s):

Bone Mass ◽

Postmenopausal Women ◽

Vertebral Fractures ◽

Patient Population ◽

Group Analysis ◽

Osteoporotic Fractures ◽

Serum Levels ◽

Low Bone Mass ◽

Differential Expression Pattern ◽

Novel Biomarkers

Background Circulating microRNAs (miRs) are currently being investigated as novel biomarkers for osteoporosis and osteoporotic fractures. Aim The aim of this study was to investigate serum levels of specific microRNAs, known regulators of bone metabolism, in postmenopausal women with low bone mass and with or without vertebral fractures (VFs). Methods For the analysis, 14 miRs were isolated from the serum of 35 postmenopausal women with low bone mass and with at least one moderate VF and 35 postmenopausal women with low bone mass without fractures. Thirty postmenopausal women with normal BMD values and no history of fractures served as controls. Main outcome parameters were changes in the expression of selected miRs in the serum of patient population and compared with controls. Results From the 14 miRs that were selected, we identified 5 miRs, namely miR-21-5p, miR-23a, miR-29a-3p, miR-124-3p and miR-2861 that were significantly deregulated in the serum of patients with low bone mass compared with controls. Serum miR-124 and miR-2861 were significantly higher, whereas miR-21, miR-23 and miR-29 were lower in patients compared with controls. In a sub-group analysis of the patient population, the expression of miR-21-5p was significantly lower among osteoporotic/osteopenic women with VFs, showing 66% sensitivity and 77% specificity in distinguishing women with a vertebral fracture. Conclusion This study identifies a differential expression pattern of miR-21-5p in the serum of women with low BMD and VFs.

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