scholarly journals Cognitive Performance in Euthymic Patients with Bipolar Disorder vs Healthy Controls: A Neuropsychological Investigation

2017 ◽  
Vol 13 (1) ◽  
pp. 71-81 ◽  
Author(s):  
M. Carlotta Palazzo ◽  
Chiara Arici ◽  
Laura Cremaschi ◽  
Marta Cristoffanini ◽  
Cristina Dobrea ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairment ◽  
Cognitive Performance ◽  
Verbal Fluency ◽  
Cognitive Task ◽  
Healthy Controls ◽  
Verbal Fluency Test ◽  
Age Related ◽  
Bipolar Patients ◽  
Fluency Test

Objectives: Cognitive impairment may affect patients with Bipolar Disorder (BD) beyond the acute episodes, qualifying as a potential endophenotype. However, which cognitive domains are specifically affected in euthymic patients with BD and the potential influence of confounding factors (e.g., age and concomitant pharmacological treatment) are still a matter of debate. The present study was, therefore, conducted to assess cognitive performance across specific domains in euthymic bipolar patients, not older than 50 years (to avoid potential age-related bias) versus healthy controls (HCs). Methods: A cognitive task battery, including the Wisconsin Card Test, Span Attention Test, Tower of London, Trail Making Test, Verbal Fluency Test, Matrices Scores and N-Back, was administered to 62 subjects (30 bipolar patients and 32 matched HCs) and differences between the groups analyzed. Results: Bipolar patients performed significantly worse than HCs in the Span Forward task, in the expression of Verbal Fluency Test (Category) and in the N-Back task (all p<.05), with marginal differences between BD I and BD II patients. Conclusion: The present study pointed out significant differences in terms of cognitive performance between euthymic bipolar patients and HCs, supporting the notion that specific cognitive functions may remain impaired even after the resolution of the acute episodes in subjects suffering from BD. Future studies on larger samples are warranted to confirm the present results and further explore potential differences in cognitive impairment across specific bipolar subtypes.

Graph analysis of verbal fluency test discriminates between patients with bipolar disorder and healthy controls

2017 ◽  
Vol 27 ◽  
pp. S829-S830
Author(s):  
K. Machalska ◽  
A. Turek ◽  
A.A. Chrobak ◽  
A. Tereszko ◽  
M. Siwek ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Verbal Fluency ◽  
Graph Analysis ◽  
Healthy Controls ◽  
Verbal Fluency Test ◽  
Fluency Test

scholarly journals Developing a Persian Verbal Fluency Test and Comparing the Results Between Healthy Persian Speakers and Persian Speakers Patients With Alzheimer Disease and Mild Cognitive Impairment

2021 ◽  
Vol 19 (4) ◽  
pp. 387-398
Author(s):  
Ahmad Reza Khatoonabadi ◽  
◽  
Mahshid Aghajanzadeh ◽  
Saman Maroufizadeh ◽  
Zahra Vahabi ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Alzheimer Disease ◽  
Verbal Fluency ◽  
Normal Group ◽  
Semantic Fluency ◽  
Verbal Fluency Test ◽  
Semantic Categories ◽  
Cognitively Intact ◽  
Fluency Test

Objectives: Phonemic and semantic fluency tasks are used for verbal fluency (VF) evaluation. The present study aimed to select the most appropriate semantic categories and the most frequent phonemes of Persian as items for the VF test. Then, we determine the test results in differentiation between cognitively intact people and those with Mild Cognitive Impairment (MCI) and Alzheimer Disease (AD). Methods: A cross-sectional study was conducted on 120 people (60 cognitively intact, 30 with AD, and 30 with MCI) in two phases. In phase one, linguists determine the most frequent phonemes at the beginning of Persian words and the most frequent semantic categories based on a survey. In phase two, the verbal fluency test was administered to cognitively intact people and those with cognitive impairment (patients with AD and MCI). One-way ANOVA and multiple linear regression were used for statistical analysis. Results: The normal subjects scored significantly higher in all phonemic and semantic fluency tasks than the patients with AD and people with MCI (P<0.05). Regarding the phonemic VF task, the phonemes /sh/, /s/, and then /a/ were better in differentiating the MCI and AD groups from the normal group. Regarding the semantic VF task, the animals’ category was better differentiated the MCI and AD groups from the normal group. Discussion: Comparing frequent phonemes and semantic categories of Persian across three groups of normal, AD, and MCI showed that some phonemes and semantic categories can be more differentiating in the VF task. However, it is a preliminary validation study, and this topic needs more investigation in the future.

scholarly journals Semantic Relations in a Categorical Verbal Fluency Test: An Exploratory Investigation in Mild Cognitive Impairment

2019 ◽  
Vol 10 ◽  
Author(s):  
Davide Quaranta ◽  
Chiara Piccininni ◽  
Alessia Caprara ◽  
Alessia Malandrino ◽  
Guido Gainotti ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Verbal Fluency ◽  
Semantic Relations ◽  
Verbal Fluency Test ◽  
Exploratory Investigation ◽  
Fluency Test

scholarly journals TWO PATTERNS ОF CT-BRAIN PERFUSION AND DC-POTENTIALS ОF THE BRAIN EVOKED COGNITIVE TASK IN DISCIRCULATORY ENCEPHALOPATHY PATIENTS

2012 ◽  
Vol 67 (10) ◽  
pp. 38-43
Author(s):  
V. F. Fokin ◽  
N. V. Ponomareva ◽  
M. V. Krotenkova ◽  
R. N. Konovalov ◽  
M. M. Tanashyan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Verbal Fluency ◽  
Cerebral Perfusion ◽  
Cognitive Task ◽  
Brain Perfusion ◽  
Verbal Fluency Test ◽  
The Brain ◽  
Fluency Test ◽  
Dc Potentials

In patients with discirculatory encephalopathy the influence of verbal fluency test on the characteristics of cerebral perfusion, DC-potentials of the brain, as well as on blood pressure and heart rate was investigated. Two patterns of responses to the verbal fluency test were observed. The first one is the process of generalized activation, manifested by the reduction of the TTP (time to peak) parameters of brain perfusion, the rise of the DC-potentials in all areas of brain and the modulation of blood pressure and heart rate. The second process, directly connected with cognitive processing, was manifested by the shifts of local characteristics of brain perfusion and DC-potentials in the frontal, temporal and central cortex, especially in the left hemisphere. Correlations were found between the characteristics of cerebral perfusion and DC-potentials on the one hand and the number of words during the verbal fluency test performance on the other hand. 

scholarly journals Sex Dependence of Cognitive Functions in Bipolar Disorder

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Aleksandra Suwalska ◽  
Dorota Łojko
Keyword(s):  
Bipolar Disorder ◽  
Working Memory ◽  
Cognitive Functioning ◽  
Cognitive Functions ◽  
Verbal Fluency ◽  
Spatial Working Memory ◽  
Lithium Carbonate ◽  
Healthy Controls ◽  
Male Patients ◽  
Bipolar Patients

The objective of the present study was to assess the performance of lithium treated euthymic bipolar patients in tests measuring spatial working memory (SWM), planning, and verbal fluency and to delineate the influence of gender on cognitive functioning. Fifty-nine euthymic bipolar patients, treated with lithium carbonate for at least 5 yr, were studied. Patients and controls underwent a neuropsychological assessment. Bipolar patients had significantly worse results than the healthy controls in the spatial memory and planning as well as verbal fluency tests. We detected a gender-related imbalance in the SWM results. Deficits in SWM were observed in male-only comparisons but not in female-only comparisons. The SWM scores were significantly poorer in male patients than in male controls. In female-only comparisons, female patients did not have significantly poorer SWM results in any category than their controls. Bipolar women scored worse in some other tests. The present study points to the different patterns of neuropsychological disturbances in female and male patients and suggests that sex-dependent differences should be taken into account in order to tailor the therapeutic intervention aimed at the improvement of cognitive functions.

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