Tau Phosphorylation and Aggregation as a Therapeutic Target in Tauopathies

2010 ◽  
Vol 9 (6) ◽  
pp. 727-740 ◽  
Author(s):  
Nahuai Badiola ◽  
Marc Suarez-Calvet ◽  
Alberto Lleo
Keyword(s):  
Therapeutic Target ◽  
Tau Phosphorylation

scholarly journals Focused ultrasound and Alzheimer’s disease A systematic review

2018 ◽  
Vol 12 (4) ◽  
pp. 353-359 ◽  
Author(s):  
Rodrigo Marmo da Costa e Souza ◽  
Inaê Carolline Silveira da Silva ◽  
Anna Beatriz Temoteo Delgado ◽  
Pedro Hugo Vieira da Silva ◽  
Victor Ribeiro Xavier Costa
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Effective Treatment ◽  
Cognitive Performance ◽  
Therapeutic Target ◽  
Focused Ultrasound ◽  
Tau Phosphorylation ◽  
Promising Therapeutic Target ◽  
Preclinical Trials

ABSTRACT Alzheimer’s disease (AD) affects millions of people, however, there is still no effective treatment. The use of focused ultrasound with microbubbles (FUS-MB) for the opening of the blood-brain barrier has been recently studied and may become a promising therapeutic target. Objective: To discuss the use of FUS-MB for the treatment of AD and to present some of the techniques used. Methods: A systematic review was performed of MEDLINE/PubMed and Biblioteca Virtual em Saúde (BVS) services, using the keywords: focused ultrasound, Alzheimer, amyloid-b. Original articles were included in the study; studies that did not focus on Alzheimer’s treatment were excluded. Results: Fifteen original studies were selected. Preclinical trials were able to reduce amyloid-b plaques and tau phosphorylation, improving cognitive performance in AD animals. Conclusion: The results are very promising, but the therapy still requires maturation. Further studies are needed to systematize all the techniques used and their effects in order to enable use in humans.

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

COX–2 is overesxpressed in ovarian endometriosis and might represent a therapeutic target

2008 ◽  
Vol 68 (S 01) ◽  
Author(s):  
A Meinel ◽  
C Leo ◽  
G Zimmermann ◽  
H Alexander ◽  
LC Horn
Keyword(s):  
Therapeutic Target ◽  
Ovarian Endometriosis ◽  
Cox 2

Investigation of BRAF fusion genes as a therapeutic target in pilocytic astrocytoma

2012 ◽  
Vol 224 (06) ◽  
Author(s):  
H Cin ◽  
J Gronych ◽  
A Korshunov ◽  
DTW Jones ◽  
D Milford ◽  
...  
Keyword(s):  
Pilocytic Astrocytoma ◽  
Therapeutic Target ◽  
Fusion Genes ◽  
Braf Fusion
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