scholarly journals Predictive Role of p53 Protein as a Single Marker or Associated with ki67 Antigen in Oral Leukoplakia: A Retrospective Longitudinal Study

2015 ◽  
Vol 9 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Davide B Gissi ◽  
Andrea Gabusi ◽  
Dora Servidio ◽  
Fabio Cervellati ◽  
Lucio Montebugnoli
Keyword(s):  
Longitudinal Study ◽  
Oral Cancer ◽  
Statistical Significance ◽  
Malignant Lesion ◽  
Oral Leukoplakia ◽  
P53 Overexpression ◽  
P53 Expression ◽  
Ki67 Expression ◽  
Predictive Role

Oral leukoplakia (OL) is the most common potentially malignant lesion of the oral cavity. Immunohistochemical analysis of p53 and Ki67 proteins is a simple and inexpensive method widely used in non-dysplastic OLs to reveal lesions predicted to develop oral cancer. The present longitudinal study evaluated the predictive role of p53 and Ki67 proteins alone or in combination in a group of OLs without dysplasia followed for many years. Seventy-seven OL patients referred to our Department between January 2006 and October 2013 underwent histochemical analysis of p53 and Ki67 expression. OLs were considered at high risk in the presence of either high p53 expression (>20%), or low/normal p53 expression associated with high Ki67 expression (Ki67/p53 ratio >3). Seven OLs evolved to OSCC during the follow-up period. Three cases had p53 overexpression, while four had a high Ki67/p53 ratio. Statistical significance was reached when samples with p53 overexpression were combined with samples with high Ki67/p53 ratio (Chi square 5.3; p<0.02). The combined immunohistochemical expression of p53 and Ki67 proteins could be a useful and simple molecular marker for early detection of non-dysplastic OLs at risk of developing oral cancer.

The predictive role of CA 19–9 kinetics for time-to-progression (TTP) and overall survival (OS) in patients receiving palliative first-line chemotherapy for advanced pancreatic cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e15637-e15637
Author(s):  
M. Haas ◽  
S. Boeck ◽  
P. Stieber ◽  
R. P. Laubender ◽  
H. Buchner ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Statistical Significance ◽  
Univariate Analysis ◽  
Advanced Pancreatic Cancer ◽  
Rank Test ◽  
First Line ◽  
Predictive Role ◽  
Pre Treatment ◽  
Line Chemotherapy

e15637 Background: Previous studies showed contradictory results for a predictive role of CA 19–9 kinetics during chemotherapy in patients (pts) with pancreatic cancer (PC). Methods: We performed a retrospective, multicenter study in order to evaluate the role of CA 19–9 as a biomarker for TTP and OS in PC. Main inclusion criteria: histological confirmed diagnosis of PC, treatment with first-line chemotherapy for advanced disease, pre-treatment CA 19–9 level of > 5.2 U/ml. As CA 19–9 measurements were conducted in different laboratories using different commercial assays, we defined a subgroup of pts where CA 19–9 was assessed exclusively by the Elecsys assay (Roche Diagnostics). For the analysis of CA 19–9 kinetics, at least one follow-up measurement between day 20 and 64 during first-line chemotherapy had to be available. Pts were divided into two subgroups of CA 19–9 responders and non-responders by cut-offs of a 25% and 50% decline, respectively. OS and TTP were estimated with the Kaplan-Meier-Method, differences between the subgroups were analyzed by using the log-rank test. Results: One hundred and eighty-six pts were included, 83 of them were tested with the Elecsys method. Median age was 63 years, 90 % of the pts were treated within prospective clinical trials. Median pre-treatment CA 19–9 was 1076 U/ml (range 5.7–100,000 U/ml), the median bilirubin was 0.6 mg/dl. Median OS and TTP were 9.8 months (mo) and 5.4 mo, respectively. In univariate analysis, pts with a CA 19–9 decline of at least 25% during chemotherapy lived significantly longer (11.9 mo vs. 8.2 mo, p=0.003) and had a significantly prolonged TTP (5.8 mo vs. 4.4 mo, p=0.018) than those with a lower decline or even CA 19–9 increase. Data for the Elecsys-measurements were comparable (OS: 13.4 mo vs. 8.6 mo, p=0.004; TTP: 7.0 mo vs. 2.6 mo, p=0.003). None of the analyses demanding a CA 19–9 drop of at least 50% reached the level of statistical significance. Conclusion: An early CA 19–9 decline of 25% during first-line chemotherapy may predict OS and TTP in pts with advanced PC. Innovative statistical methods are required to improve our understanding of the utility of CA 19–9 as a predictive biomarker in PC. [Table: see text]

The predictive value of p53, MDM-2, cyclin D1 and Ki67 in the progression from low-grade dysplasia towards carcinoma of the larynx

1998 ◽  
Vol 112 (5) ◽  
pp. 455-459 ◽  
Author(s):  
Lorenzo Pignataro ◽  
Pasquale Capaccio ◽  
Giancarlo Pruneri ◽  
Nadia Carboni ◽  
Roberto Buffa ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Low Grade ◽  
Ki67 Expression ◽  
Laryngeal Mucosa ◽  
Carcinoma Of The Larynx ◽  
Immunohistochemical Assessment ◽  
Predictive Role ◽  
Low Grade Dysplasia

AbstractTo evaluate the predictive role of the oncogenes p53, MDM-2 and cyclin D1, and the proliferative marker Ki67, in the progression from low-grade dysplasia to carcinoma of the larynx. We studied immunohistochemically a series of 32 low-grade pre-neoplastic laryngeal lesions, 10 of which progressed to invasive carcinoma. Immunoreactivity in more than 10 per cent of the dysplastic cells was detected in five cases immunostained with anti-p53 (≈ 15 per cent), in two with anti-MDM-2 (≈ six per cent), and 11 with anti-Ki67 antibodies (≈ 34 per cent), whereas none of the cases showed cyclin D1 overexpression. No significant association was found between p53 and MDM-2 immunoreactivity and the evolution to carcinoma; on the contrary, Ki67 expression was detectable in all but one of the 10 cases developing an infiltrative tumour (90 per cent), and in two of the 22 cases that did not progress (≈ nine per cent) (p = 0.01). These findings indicate that immunohistochemical assessment of the proliferative index in bioptic samples of dysplastic laryngeal mucosa may be useful in selecting patients who should undergo a more specific follow-up evaluation.

The predictive role of self‐compassion in cancer patients' symptoms of depression, anxiety, and fatigue: A longitudinal study

2019 ◽  
Vol 28 (9) ◽  
pp. 1918-1925 ◽  
Author(s):  
Lei Zhu ◽  
Juntao Yao ◽  
Jun Wang ◽  
Liyang Wu ◽  
Yuhan Gao ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Cancer Patients ◽  
Symptoms Of Depression ◽  
Self Compassion ◽  
Predictive Role

scholarly journals Role of Tobacco in the Development of Oral Leukoplakia and Oral Cancer

Dentistry ◽  
2018 ◽  
Vol 08 (06) ◽  
Author(s):  
Maka Sabashvili ◽  
Elene Gigineishvili ◽  
Maia Jikia ◽  
Tamta Chitaladze
Keyword(s):  
Oral Cancer ◽  
Oral Leukoplakia

Tumour response to preoperative anthracycline-based chemotherapy in operable breast cancer: the predictive role of p53 expression

2006 ◽  
Vol 42 (10) ◽  
pp. 1369-1379 ◽  
Author(s):  
J. Sven D. Mieog ◽  
Jos A. van der Hage ◽  
Marc J. van de Vijver ◽  
Cornelis J.H. van de Velde
Keyword(s):  
Breast Cancer ◽  
Tumour Response ◽  
Operable Breast Cancer ◽  
P53 Expression ◽  
Predictive Role

scholarly journals TERTp mutations and p53 expression in head and neck cutaneous basal cell carcinomas with different aggressive features

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
António Castanheira ◽  
Maria João Vieira ◽  
Mafalda Pinto ◽  
Carolina Dias ◽  
Luísa Prada ◽  
...  
Keyword(s):  
Head And Neck ◽  
Basal Cell ◽  
Growth Pattern ◽  
P53 Protein ◽  
Tertiary Hospital ◽  
P53 Overexpression ◽  
P53 Expression ◽  
Mutation Status ◽  
Basal Cell Carcinomas

AbstractCutaneous basal cell carcinoma (cBCC) is an economic burden to health services, due to its great morbidity and increasing incidence in old people. Infiltrative cBCCs and cBCCs with micronodular pattern are considered as more aggressive. The role of p53 expression and TERTp mutation on cBCC behavior remains to be clarified. We aimed to assess TERTp mutations and p53 expression in relation to the cBCC histological subtype in a cohort of patients referred to an ENT Department of a tertiary Hospital of Northern Portugal. We performed a retrospective clinicopathological and histological review of the head and neck cBCCs followed-up at the otorhinolaryngology department of Trás-os-Montes e Alto Douro hospital (January 2007–June 2018). We assessed TERTp mutations in 142 cBCCs and p53 protein expression, through immunohistochemistry, in 157 cBCCs. We detected TERTp mutations in 43.7% of cBCCs and p53 overexpression in 60.5% of cBCCs. We spotted association of p53 overexpression and TERTp mutation with necrosis. In the infitrative-growth pattern cBCCs, there was no significant association with the clinical and histological features evaluated, except for necrosis. In the indolent-growth cBCCs, we identified a significant association of TERTp mutation status with female sex, necrosis, multiple cBCCs, and p53 positive expression. Our results suggest that TERTp mutation may be useful to identify more aggressive features in the indolent-growth pattern cBCCs (nodular and superficial subtypes). Further studies with larger cohorts are warranted to clarify the relevance of TERTp mutation in cBCCs.

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