Multifunctional Liquid Crystal Nanoparticles for Cancer Therapy

Cancer is the second foremost reason for worldwide death, affecting every country of the globe. However, 70% of cancer-related death was reported from low- and middle-income nations. Delay in the detection and intervention of therapeutic agents in cancer patients also promoted a cancer-related mortality index. Currently, numerous nanomedicines are under development for advancing tumor diagnosis and therapeutic capability. Recently, liquid crystalline nanoparticles (LCNPs) have emerged as an attractive drug delivery system for both intravenous and non-intravenous applications. The widely explored LCNPs for cancer therapy include cubosomes and hexosomes. They have significant advantages over other drug delivery system, which includes, high internal surface area, unique solubilization properties and sustained release of entrapped drug molecules and co-loading of imaging and therapeutic agents in a single system. In this review, we have briefly discussed the advantages of LCNPs, preparation methods, and their multifunctional role in treating various cancers.

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An Update on Recent Advances in Cubosome: A Novel Drug Delivery System

Current Drug Metabolism ◽

10.2174/1389200221666210105121532 ◽

2021 ◽

Vol 21 ◽

Author(s):

Madhukar Garg ◽

Anju Goyal ◽

Sapna Kumari

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Lipid Bilayers ◽

Delivery System ◽

Liquid Crystalline ◽

Three Dimensional ◽

Biologically Active ◽

Potential Applications ◽

Health Related ◽

Novel Drug

: Cubosomes are highly stable nanostructured liquid crystalline dosage delivery form derived from amphiphilic lipids and polymer-based stabilizers converting it in a form of effective biocompatible carrier for the drug delivery. The delivery form comprised of bicontinuous lipid bilayers arranged in three dimensional honeycombs like structure provided with two internal aqueous channels for incorporation of number of biologically active ingredients. In contrast liposomes they provide large surface area for incorporation of different types of ingredients. Due to the distinct advantages of biocompatibility and thermodynamic stability, cubosomes have remained the first preference as method of choice in the sustained release, controlled release and targeted release dosage forms as new drug delivery system for the better release of the drugs. As lot of advancement in the new form of dosage form has bring the novel avenues in drug delivery mechanisms so it was matter of worth to compile the latest updates on the various aspects of mentioned therapeutic delivery system including its structure, routes of applications along with the potential applications to encapsulate variety drugs to serve health related benefits.

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Advancement in Microsponge Drug Delivery System: Preparation Methods, Patents and Commercial Utility

Recent Patents on Drug Delivery & Formulation ◽

10.2174/1872211308666140305222905 ◽

2014 ◽

Vol 8 (2) ◽

pp. 101-110 ◽

Cited By ~ 2

Author(s):

Deeksha Dubey ◽

Rishabha Malviya ◽

Pramod Sharma

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Preparation Methods

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Preparation and evaluation of gemcitabin and cisplatin-entrapped Folate-PEGylated liposomes as targeting co-drug delivery system in cancer therapy

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2021.102756 ◽

2021 ◽

pp. 102756

Author(s):

Pooneh Pakdaman Goli ◽

Maryam Bikhof Torbati ◽

Kazem Parivar ◽

Azim Akbarzadeh Khiavi ◽

Mohammad Yousefi

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Delivery System ◽

Delivery System ◽

Pegylated Liposomes ◽

Preparation And Evaluation

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Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1714421115 ◽

2018 ◽

Vol 115 (3) ◽

pp. 501-506 ◽

Cited By ~ 356

Author(s):

Meng Qiu ◽

Dou Wang ◽

Weiyuan Liang ◽

Liping Liu ◽

Yin Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Near Infrared ◽

Black Phosphorus ◽

Deep Penetration ◽

Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

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Recent Applications of Nanoemulsion Based Drug Delivery System: A Review

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00502 ◽

2021 ◽

pp. 2852-2858

Author(s):

Asif Eqbal ◽

Vaseem Ahamad Ansari ◽

Abdul Hafeez ◽

Farogh Ahsan ◽

Mohd Imran ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Transdermal Drug Delivery ◽

Therapeutic Agents ◽

Topical Drug Delivery ◽

Transdermal Drug Delivery System ◽

Small Droplet ◽

Pharmaceutical Application ◽

System A

Nanoemulsions are drug transporters for the delivery of therapeutic agents. They possess the small droplet size having the range of 20×10-9-200×10-9m. The main purpose of using Nanoemulsion is to enhance the drug bio- availability of transdermal drug delivery system. With the help of phase diagram, we can select the components of nanoemulsion depending upon formulas ratio of oil phase, surfactant/co-surfactant and water phase. Nanoemulsion directly used as a topical drug delivery in skin organs. The most useable pharmaceutical application has been developed till date to provide systemic effects to penetrating the full thickness of skin organ layer nanoemulsions can be administered through variety of routes such as percutaneous, perioral, topical, transdermal, ocular and parental administration of medicaments. Nanoemulsions are transparent and slightly opalescent. Nanoemulsion can be prepared through various methods. Nanoemulsions are transparent and slightly opalescent. Factor affecting nanoemulsions are surfactant, viscosity, lipophilic, drug content, pH, concentration of each component, and methodology of formulation. It is unfeasible to test all factors at the various levels. Design of formulation when it comes to experimental design it gives an excellent approach through reducing the time and money.

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The in vivo transformation and pharmacokinetic properties of a liquid crystalline drug delivery system

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2017.08.098 ◽

2017 ◽

Vol 532 (1) ◽

pp. 345-351 ◽

Cited By ~ 3

Author(s):

Andrew Otte ◽

Yahira M. Báez-Santos ◽

Ellina A. Mun ◽

Bong-Kwan Soh ◽

Young-nam Lee ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Liquid Crystalline ◽

Pharmacokinetic Properties

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A REVIEW ON FAST DISSOLVING TABLET

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v8i5.1888 ◽

2018 ◽

Vol 8 (5) ◽

pp. 50-55 ◽

Cited By ~ 4

Author(s):

RD Rahane ◽

Punit R. Rachh

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Patient Compliance ◽

Delivery System ◽

New Technologies ◽

Oral Drug Delivery ◽

Oral Drug ◽

Preparation Methods ◽

Orally Disintegrating Tablets ◽

Increasing Demand

The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. The popularity and usefulness of the formulation resulted in development of several FDT technologies. These techniques render the disintegration of tablet rapidly and dissolve in mouth in five seconds without chewing and the need of water which is advantageous mainly for pediatrics, geriatrics and patients having difficulty in swallowing tablets and capsules. Formulation of a convenient dosage form for administration, by considering swallowing difficulty and poor patient compliance, leads to development of orally disintegrating tablets. Conventional preparation methods are spray drying, freeze drying, direct compression, Molding, and sublimation while new technologies have been developed for the production of orodispersible tablets. Keywords: Fast Dissolving Tablet, drug delivery system, fast disintegrating, fast melting.

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