Advancement in Microsponge Drug Delivery System: Preparation Methods, Patents and Commercial Utility

The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. The popularity and usefulness of the formulation resulted in development of several FDT technologies. These techniques render the disintegration of tablet rapidly and dissolve in mouth in five seconds without chewing and the need of water which is advantageous mainly for pediatrics, geriatrics and patients having difficulty in swallowing tablets and capsules. Formulation of a convenient dosage form for administration, by considering swallowing difficulty and poor patient compliance, leads to development of orally disintegrating tablets. Conventional preparation methods are spray drying, freeze drying, direct compression, Molding, and sublimation while new technologies have been developed for the production of orodispersible tablets. Keywords: Fast Dissolving Tablet, drug delivery system, fast disintegrating, fast melting.

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Multifunctional Liquid Crystal Nanoparticles for Cancer Therapy

Current Nanomaterials ◽

10.2174/2405461506666210118114851 ◽

2021 ◽

Vol 6 (1) ◽

pp. 4-16

Author(s):

Abhishesh K. Mehata ◽

Deepa Dehari ◽

Amit Gupta ◽

Dangali C. Rabin ◽

Alim Miya

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Delivery System ◽

Delivery System ◽

Liquid Crystalline ◽

Internal Surface ◽

Therapeutic Agents ◽

Internal Surface Area ◽

Preparation Methods ◽

Middle Income

Cancer is the second foremost reason for worldwide death, affecting every country of the globe. However, 70% of cancer-related death was reported from low- and middle-income nations. Delay in the detection and intervention of therapeutic agents in cancer patients also promoted a cancer-related mortality index. Currently, numerous nanomedicines are under development for advancing tumor diagnosis and therapeutic capability. Recently, liquid crystalline nanoparticles (LCNPs) have emerged as an attractive drug delivery system for both intravenous and non-intravenous applications. The widely explored LCNPs for cancer therapy include cubosomes and hexosomes. They have significant advantages over other drug delivery system, which includes, high internal surface area, unique solubilization properties and sustained release of entrapped drug molecules and co-loading of imaging and therapeutic agents in a single system. In this review, we have briefly discussed the advantages of LCNPs, preparation methods, and their multifunctional role in treating various cancers.

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An Updated Comprehensive Review on Nanosponges – Novel Emerging Drug Delivery System

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00778 ◽

2021 ◽

pp. 4476-4484

Author(s):

Radhika Parasuram Rajam ◽

Kavin Raj Muthukumar

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Skin Irritation ◽

Vital Role ◽

Colloidal System ◽

Topical Drug Delivery ◽

Complex Molecules ◽

Preparation Methods ◽

Hydrophilic Drugs

Medical researchers found problem in targeting the drug delivery. The Nanotechnology has become highly competitive and rapidly evolving as more and more developments in delivery systems are being integrated to optimize the efficacy and cost effectiveness of therapy. The development of new and complex molecules Nano sponges has potential to solve this problem. Nano sponge drug delivery system has emerged as one of the most promising fields in pharmaceutics. Nano sponges consist of nonporous particles that can suspend or entrap a wide variety of substances, and then be incorporated into a dosage form. Nano sponge play vital role in targeting drug delivery in a controlled manner. Both lipophilic and hydrophilic drugs are incorporated in Nano sponge. The outer surface is typically porous, allowing controlled release of drug. Nano sponge delivery system (NDS) provides increased efficacy with enhanced safety, extended product stability, improved formulation flexibility, reduced side effects and superior aesthetic properties in an efficient and novel manner. Adding up they are non-irritating, non-mutagenic, non-allergenic and non-toxic. Topical drug delivery system also faced many problems like poor permeability, skin irritation, allergic reactions etc. The new developed colloidal system called Nano sponge has potential to overcome this problem. In short Nano sponges encompass many favorable characteristics which make them a versatile drug delivery vehicle. The present review explores on the preparation methods, applications of Nano sponges in the field of drug delivery.

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Nanoemulsion: An Advanced Vehicle For Efficient Drug Delivery

Drug Research ◽

10.1055/s-0043-115124 ◽

2017 ◽

Vol 67 (11) ◽

pp. 617-631 ◽

Cited By ~ 14

Author(s):

Asad Ali ◽

Vaseem Ansari ◽

Usama Ahmad ◽

Juber Akhtar ◽

Afroz Jahan

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Absorption Rate ◽

Colloidal System ◽

Preparation Methods ◽

System A ◽

Hydrophilic Drug ◽

Conventional Drug ◽

Evaluation Parameters

AbstractAdvanced drug delivery system has now gained preference over the conventional drug delivery system. One such research is nanoemulsion which is famous among the researchers because of ease of formation, stability, clarity, increased absorption rate leading to increasing in bioavailability and potential to form a formulation with both lipophilic as well as the hydrophilic drug. Long lasting stability (up to years) and ability to encapsulate both lipophilic and hydrophilic drug has given this colloidal system a valuable position in drug delivery. This article contains information on components required for its fabrication, preparation methods and evaluation parameters along with its application in drug delivery and future aspects of this advanced drug delivery system.

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