Neuroimmune Regulation of Pain and Inflammation: Targeting Glial Cells and Nociceptor Sensory Neurons Interaction

2017 ◽  
pp. 146-200 ◽  
Author(s):  
Victor Fattori ◽  
Sergio M. Borghi ◽  
Ana C. Rossaneis ◽  
Mariana M. Bertozzi ◽  
Thiago M. Cunha ◽  
...  
Keyword(s):  
Sensory Neurons ◽  
Glial Cells ◽  
Inflammation Targeting

Long-term cell culture of electrically active sensory neurons free of glial cells

1977 ◽  
Vol 5 (3-4) ◽  
pp. 153-157 ◽  
Author(s):  
Ellen Rieske ◽  
Georg W. Kreutzberg
Keyword(s):  
Cell Culture ◽  
Sensory Neurons ◽  
Glial Cells

scholarly journals sli is required for proper morphology and migration of sensory neurons in the Drosophila PNS

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Madison Gonsior ◽  
Afshan Ismat
Keyword(s):  
Nervous System ◽  
Sensory Neurons ◽  
Glial Cells ◽  
System Development ◽  
Nervous System Development ◽  
Final Position ◽  
Neuron Development ◽  
Guidance Cues ◽  
And Migration

Abstract Neurons and glial cells coordinate with each other in many different aspects of nervous system development. Both types of cells are receiving multiple guidance cues to guide the neurons and glial cells to their proper final position. The lateral chordotonal organs (lch5) of the Drosophila peripheral nervous system (PNS) are composed of five sensory neurons surrounded by four different glial cells, scolopale cells, cap cells, attachment cells and ligament cells. During embryogenesis, the lch5 neurons go through a rotation and ventral migration to reach their final position in the lateral region of the abdomen. We show here that the extracellular ligand sli is required for the proper ventral migration and morphology of the lch5 neurons. We further show that mutations in the Sli receptors Robo and Robo2 also display similar defects as loss of sli, suggesting a role for Slit-Robo signaling in lch5 migration and positioning. Additionally, we demonstrate that the scolopale, cap and attachment cells follow the mis-migrated lch5 neurons in sli mutants, while the ventral stretching of the ligament cells seems to be independent of the lch5 neurons. This study sheds light on the role of Slit-Robo signaling in sensory neuron development.

Protection by an ACTH4-9analogue against the toxic effects of cisplatin and taxol on sensory neurons and glial cells in vitro

1994 ◽  
Vol 39 (2) ◽  
pp. 178-185 ◽  
Author(s):  
E. M. Hol ◽  
V. Mandys ◽  
P. Sodaar ◽  
W. H. Gispen ◽  
P. R. Bär
Keyword(s):  
Sensory Neurons ◽  
Glial Cells ◽  
Toxic Effects

scholarly journals Sensory neurons of the Atonal lineage pioneer the formation of glomeruli within the adult Drosophila olfactory lobe

Development ◽  
2002 ◽  
Vol 129 (5) ◽  
pp. 1251-1260 ◽  
Author(s):  
Dhanisha Jhaveri ◽  
Veronica Rodrigues
Keyword(s):  
Sensory Neurons ◽  
Glial Cells ◽  
Crucial Role ◽  
Sensory Innervation ◽  
Projection Neurons ◽  
Olfactory Lobe ◽  
Adult Drosophila

The first centers for processing of odor information by animals lie in the olfactory lobe. Sensory neurons from the periphery synapse with interneurons in anatomically recognizable units, termed glomeruli, seen in both insects and vertebrates. The mechanisms that underlie the formation of functional maps of the odor-world in the glomeruli within the olfactory lobe remains unclear. We address the basis of sensory targeting in the fruitfly Drosophila and show that one class of sensory neurons, those of the Atonal lineage, plays a crucial role in glomerular patterning. Atonal-dependent neurons pioneer the segregation of other classes of sensory neurons into distinct glomeruli. Furthermore, correct sensory innervation is necessary for the arborization of projection neurons into glomeruli and for the elaboration of processes of central glial cells into the lobe.

scholarly journals Satellite glial cells promote regenerative growth in sensory neurons

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Oshri Avraham ◽  
Pan-Yue Deng ◽  
Sara Jones ◽  
Rejji Kuruvilla ◽  
Clay F. Semenkovich ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Nerve Injury ◽  
Sensory Neurons ◽  
Glial Cells ◽  
Fatty Acid Synthase ◽  
Axon Regeneration ◽  
Nerve Repair ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Satellite Glial Cells

Abstract Peripheral sensory neurons regenerate their axon after nerve injury to enable functional recovery. Intrinsic mechanisms operating in sensory neurons are known to regulate nerve repair, but whether satellite glial cells (SGC), which completely envelop the neuronal soma, contribute to nerve regeneration remains unexplored. Using a single cell RNAseq approach, we reveal that SGC are distinct from Schwann cells and share similarities with astrocytes. Nerve injury elicits changes in the expression of genes related to fatty acid synthesis and peroxisome proliferator-activated receptor (PPARα) signaling. Conditional deletion of fatty acid synthase (Fasn) in SGC impairs axon regeneration. The PPARα agonist fenofibrate rescues the impaired axon regeneration in mice lacking Fasn in SGC. These results indicate that PPARα activity downstream of FASN in SGC contributes to promote axon regeneration in adult peripheral nerves and highlight that the sensory neuron and its surrounding glial coat form a functional unit that orchestrates nerve repair.

scholarly journals Novel Analgesics with Peripheral Targets

2020 ◽  
Vol 17 (3) ◽  
pp. 784-825
Author(s):  
Cosmin I. Ciotu ◽  
Michael J. M. Fischer
Keyword(s):  
Sensory Neurons ◽  
Inflammatory Mediators ◽  
Inflammatory Process ◽  
Early Stage ◽  
Cellular Level ◽  
Proinflammatory Mediators ◽  
Inflammation Targeting ◽  
Anti Inflammatory ◽  
Current Stage ◽  
Inflammatory Effect

Abstract A limited number of peripheral targets generate pain. Inflammatory mediators can sensitize these. The review addresses targets acting exclusively or predominantly on sensory neurons, mediators involved in inflammation targeting sensory neurons, and mediators involved in a more general inflammatory process, of which an analgesic effect secondary to an anti-inflammatory effect can be expected. Different approaches to address these systems are discussed, including scavenging proinflammatory mediators, applying anti-inflammatory mediators, and inhibiting proinflammatory or facilitating anti-inflammatory receptors. New approaches are contrasted to established ones; the current stage of progress is mentioned, in particular considering whether there is data from a molecular and cellular level, from animals, or from human trials, including an early stage after a market release. An overview of publication activity is presented, considering a IuPhar/BPS-curated list of targets with restriction to pain-related publications, which was also used to identify topics.

scholarly journals Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit

2021 ◽  
Author(s):  
Shinji Urata ◽  
Megumi Kishimoto-Urata ◽  
Ryoji Kagoya ◽  
Fumiaki Imamura ◽  
Shin Nagayama ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Olfactory Bulb ◽  
Sensory Neurons ◽  
Glial Cells ◽  
Dendritic Spines ◽  
Olfactory Dysfunction ◽  
Olfactory Pathway ◽  
Time Points ◽  
Syrian Golden Hamsters ◽  
The Impact

The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory neurons, prolonged activation of glial cells in the olfactory bulb, and a decrease in the density of dendritic spines within the hippocampus. These data may be useful for elucidating the mechanism underlying long-lasting olfactory dysfunction and cognitive impairment as a post-acute COVID-19 syndrome.

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