Which Strategies can be Adopted against Heavy Metal Intoxication?

SummaryLead (Pb), Cadmium (Cd) and Mercury (Hg) are recognized for their deleterious effect on the environment and immunity where subsequently compromised immune response affects the susceptibility to the potential parasitic infections. This study examined the host cytokine response after heavy metal intoxication (Pb, Cd, and Hg) and subsequent Ascaris suum infection in BALB/c mice. Pb modulated murine immune response towards the Th2 type of response (delineated by IL-5 and IL-10 cytokine production) what was also dominant for the outcome of A. suum infection. Chronic intoxication with Pb caused a more intensive development of the parasite infection. Cd stimulated the Th1 immune response what was associated with increase in IFN-γ production and reduction of larvae present in the liver of intoxicated mice. The larval burden was also low in mice intoxicated with Hg. This was probably not related to the biased Th1/Th2 type of immune response, but rather to the bad host conditions caused by mercury toxicity and high level of pro-cachectic cytokine TNF-α.

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Neuropathology of heavy metal intoxication.

Environmental Health Perspectives ◽

10.1289/ehp.7826117 ◽

1978 ◽

Vol 26 ◽

pp. 117-120 ◽

Cited By ~ 17

Author(s):

M R Krigman

Keyword(s):

Heavy Metal ◽

Heavy Metal Intoxication

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Time-resolved monitoring of heavy-metal intoxication in single hair by laser ablation ICP–DRCMS

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-005-3283-4 ◽

2005 ◽

Vol 383 (3) ◽

pp. 500-508 ◽

Cited By ~ 46

Author(s):

Christina Stadlbauer ◽

Thomas Prohaska ◽

Christian Reiter ◽

Anna Knaus ◽

Gerhard Stingeder

Keyword(s):

Heavy Metal ◽

Laser Ablation ◽

Time Resolved ◽

Single Hair ◽

Heavy Metal Intoxication

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A case of multiple sclerosis improvement following removal of heavy metal intoxication

BioMetals ◽

10.1007/s10534-012-9537-7 ◽

2012 ◽

Vol 25 (3) ◽

pp. 569-576 ◽

Cited By ~ 17

Author(s):

Alessandro Fulgenzi ◽

Sante Guido Zanella ◽

Mario Mauro Mariani ◽

Daniele Vietti ◽

Maria Elena Ferrero

Keyword(s):

Multiple Sclerosis ◽

Heavy Metal ◽

Heavy Metal Intoxication

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THE RESULTS OF STUDYING THE EFFICIENCY OF DIATOMITE AT INTOXICATION OF ANIMALS WITH CADMIUM AND LEAD

Problems of Veterinary Sanitation, Hygiene and Ecology ◽

10.36871/vet.san.hyg.ecol.202102018 ◽

2021 ◽

Vol 1 (2) ◽

pp. 214-222

Author(s):

V.I. Dorozhkin ◽

◽

G.I. Pavlenko ◽

N.S Pavlova ◽

D.A. Drozdov ◽

...

Keyword(s):

Heavy Metal ◽

Body Weight ◽

Blood Serum ◽

Feed Additive ◽

Protective Properties ◽

Sh Groups ◽

Lead And Cadmium ◽

White Rats ◽

Cadmium And Lead ◽

Heavy Metal Intoxication

The combination of cadmium and lead in doses at the level of 10 MPC for feed caused in white rats a decrease in body weight and immunoglobulin content in blood serum, an increase in the summation threshold indicator, a decrease of the amount of protein in urine and SH-groups in blood serum, a significant increase in mass coefficients of the liver and kidneys. The use of diatomite as a means to reduce heavy metal intoxication slightly increased body weight. The use of means did not lead to normalization of the summation threshold indicator, did not significantly affect the content of SH-groups. In the group of animals treated with diatomite, the mass coefficients of the liver remained significantly higher than the control values. The obtained results indicate that diatomite did not show protective properties as a feed additive to reduce lead and cadmium intoxication.

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Effect of heavy metal intoxication on macrophage metabolic activity of mice infected with Ascaris suum

Helminthologia ◽

10.2478/s11687-014-0226-7 ◽

2014 ◽

Vol 51 (3) ◽

pp. 171-180 ◽

Cited By ~ 1

Author(s):

M. Jalčová ◽

E. Dvorožňáková

Keyword(s):

Heavy Metal ◽

Metabolic Activity ◽

Ascaris Suum ◽

Parasitic Infection ◽

Parasite Burden ◽

Peritoneal Macrophages ◽

Oxygen Radical ◽

O2 Production ◽

Larval Burden ◽

Heavy Metal Intoxication

AbstractThe effect of heavy metal intoxication on superoxide anion (O2 −) production and larval burden during experimental Ascaris suum infection was studied. Mice were chronically intoxicated with lead (Pb), cadmium (Cd) or mercury (Hg) and subsequently infected with A. suum. The metabolic activity of peritoneal macrophages in mice intoxicated with Pb was suppressed and subsequent parasitic infection did not change this inhibition. Cd intoxication increased the superoxide production and also stimulated the activity of this oxygen radical after A. suum infection. Intoxication with Hg had a stimulative effect on the macrophage metabolic activity and subsequent A. suum infection moderately reduced this activity. Parasite burden was different depending on a type of heavy metal intoxication. Pb intoxication moderately increased the parasite burden in the liver and lungs of intoxicated mice. In contrast, Cd and Hg intoxication triggered a marked reduction of A. suum larvae in the liver and lungs of intoxicated mice, respectively. Monitored heavy metals differed in their immunomodulatory effect on metabolic activity of macrophages what also altered the intensity of the parasite infection in the hosts.

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Renal Na-Si cotransporter NaSi-1 is inhibited by heavy metals

AJP Renal Physiology ◽

10.1152/ajprenal.1998.274.2.f283 ◽

1998 ◽

Vol 274 (2) ◽

pp. F283-F289 ◽

Cited By ~ 7

Author(s):

Daniel Markovich ◽

David Knight

Keyword(s):

Heavy Metals ◽

Heavy Metal ◽

Structural Similarity ◽

Transport Systems ◽

Maximal Velocity ◽

Michaelis Constant ◽

Initial Report ◽

Heavy Metal Intoxication ◽

Inorganic Sulfate ◽

Renal Brush Border

Heavy metal intoxication leads to a number of reabsorptive and secretory defects in renal transport systems. We have studied the effects of several heavy metals on the expression of the renal Na-Si cotransporter NaSi-1. NaSi-1 cRNA was injected into Xenopusoocytes, and Na-Si cotransport activity was measured in the presence of mercury, lead, cadmium, or chromium. Mercury strongly inhibited NaSi-1 transport irreversibly by reducing both maximal velocity ( V max) and Michaelis constant ( K m) for inorganic sulfate (Si). Lead inhibited NaSi-1 transport reversibly by decreasing V max but not K m for Si. Cadmium showed weak reversible inhibition of NaSi-1 transport by decreasing only NaSi-1 V max. Chromium strongly inhibited NaSi-1 cotransport reversibly by reducing K m for Si by sevenfold, most probably by binding to the Si site, due to the strong structural similarity between the C[Formula: see text] and[Formula: see text] substrates. In conclusion, this study presents an initial report demonstrating heavy metals inhibit renal brush border Na-Sicotransport via the NaSi-1 protein through various mechanisms and that this blockade may be responsible for sulfaturia following heavy metal intoxication.

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Chromium-Cobalt Intoxication with Intense Systemic Complications following Total Hip Revision after Per-Operative Ceramic Fracture

Case Reports in Orthopedics ◽

10.1155/2019/4209796 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Paul Lecoanet ◽

Mathias Blangis ◽

Matthieu Garcia ◽

Yohan Legallois ◽

Thierry Fabre

Keyword(s):

Heavy Metal ◽

Case Report ◽

Revision Surgery ◽

Hip Revision ◽

Systemic Complications ◽

Ceramic Fracture ◽

Ceramic Components ◽

Systemic Symptoms ◽

Heavy Metal Intoxication ◽

Rapid Regression

Introduction. Heavy metal intoxication after arthroplasty is extremely rare but could be lethal. Case Report. We report the case of a 69-year-old woman, who presented intense systemic symptoms of chromium-cobalt intoxication after revision of per-operative fractured ceramic components with metal-on-polyethylene. Systemic toxicity occurred a year after surgery and expressed brutally with mostly central neurological symptoms. Chelation associated with revision surgery allowed rapid regression of all symptoms. Conclusion. Revision of fractured ceramic, even per-operatively, should not be done with metal-on-polyethylene components, in order to avoid potentially lethal metal intoxication.

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