Abstract. The work examines the most dangerous, according to the results of certification of workplaces, professions of railway transport: driver (assistant) of an electric locomotive and a diesel locomotive, an attendant at a railway station, a track fitter, an electrician of a contact network. An analysis of the legislative acts in force in the Republic of Belarus, as well as local regulatory legal acts created on their basis, OSH management systems based on STB ISO 45001, the results of workplace certification showed the need to create a systematic approach to managing the risks of developing occupational diseases in the most dangerous professions on the railway. The work systematizes the factors that have the greatest influence on the risk of developing occupational diseases, based on the generalization and analysis of certification of workplaces, the leading production factors of the listed professions are highlighted.