Methanolic Extract of PhyllanthusniruriAmeliorates certain  Biochemical and Metabolic Changes in Streptozotocin-Induced Diabetic Mice

2020 ◽  
Vol 13 (4) ◽  
pp. 1879-1885
Author(s):  
Vinay Bhushan Kumar
Keyword(s):  
Methanolic Extract ◽  
Metabolic Changes ◽  
Diabetic Mice

Sex-Specific Metabolic Changes in Peripheral Organs of Diabetic Mice

2020 ◽  
Vol 19 (8) ◽  
pp. 3011-3021 ◽  
Author(s):  
Xi Zhang ◽  
Hangying Xu ◽  
Jie Ning ◽  
Hui Ji ◽  
Junjie Yan ◽  
...  
Keyword(s):  
Metabolic Changes ◽  
Diabetic Mice ◽  
Peripheral Organs

NMR-based metabolomics characterizes metabolic changes in different brain regions of streptozotocin-induced diabetic mice with cognitive decline

2020 ◽  
Vol 35 (7) ◽  
pp. 1165-1173 ◽  
Author(s):  
Tingting Zhang ◽  
Hong Zheng ◽  
Kai Fan ◽  
Nengzhi Xia ◽  
Jiance Li ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Brain Regions ◽  
Metabolic Changes ◽  
Diabetic Mice

Evaluation of anti-diabetic activity of methanolic extract from the bark of Atalantia monophylla (Linn.) in alloxan-induced diabetic mice

2012 ◽  
Vol 6 (2) ◽  
pp. 133 ◽  
Author(s):  
Ankur Jindal ◽  
Baldev Gautam ◽  
Shvetank Bhatt ◽  
Dilip Pandey ◽  
Radhakrishnan Mahesh
Keyword(s):  
Methanolic Extract ◽  
Diabetic Mice

scholarly journals Methanolic Extract of Myrsine africana Leaf Ameliorates Hyperglycemia and Dyslipidemia in Alloxan-Induced Diabetic Albino Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Yosef Eshetie Amare
Keyword(s):  
Glycated Hemoglobin ◽  
Methanolic Extract ◽  
Antioxidant Activities ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Diabetic Mice ◽  
Metabolizing Enzymes ◽  
Standard Drug ◽  
Significant Difference ◽  
Administration Method

Background. Diabetes mellitus is one of the leading public health problems globally, and its prevalence is increasing in Ethiopia. The current drugs for people with diabetes are costly, less effective, and less safe with a challenging administration method. Thus, globally, the need for alternative herbal antidiabetic medicines is increasing. In the previous studies, antioxidant activities have been seen in crude extracts of M. africana leaves, which is an auspicious sign of antidiabetic property. Accordingly, this study has evaluated the antidiabetic and antidyslipidemic activities of methanolic extract of M. africana leaves. Methods. Hypoglycemic and antihyperglycemic activities of the three doses (250 mg/kg, 500 mg/kg, and 1000 mg/kg) of crude methanolic extract of M. africana leaf were studied on normoglycemic, oral glucose-loaded, and alloxan-induced diabetic mice models. The effect of the extract on diabetic dyslipidemia, insulin and glycated hemoglobin levels, carbohydrate-metabolizing enzymes, and body weight was also studied in alloxan-induced diabetic mice. Glibenclamide (5 mg/kg) was used as a standard drug in all cases. Data analysis was carried out using mixed-design ANOVA. A P value of ≤0.05 was considered a statistically significant difference. Results. The methanolic extract of M. africana leaf did not show acute toxicity up to the dose of 5000 mg/kg and showed better glucose utilization in the oral glucose tolerance test. After 14 days of treatment, M. africana leaf extract decreased the blood glucose level, glycated hemoglobin, glucose-6-phosphatase, and fructose-1-6-bisphosphatase in diabetic mice. In contrast, it increased hexokinase and insulin levels in diabetic mice. Moreover, weight loss and dyslipidemia profiles have been corrected significantly in diabetic mice. Conclusion. M. africana leaves showed antihyperglycemic and antidyslipidemic effects in alloxan-induced diabetic mice. That suggests M. africana may be a potential treatment option for diabetes in the future. However, further molecular studies are required to analyze the mechanisms.

scholarly journals Phytochemical Screening and Antidiabetic, Antihyperlipidemic, and Antioxidant Effects of Leptopus Cordifolius Decne. In Diabetic Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Shahid Rahman ◽  
Gul Jan ◽  
Farzana Gul Jan ◽  
Hafeez Ur Rahim
Keyword(s):  
Blood Glucose ◽  
Total Cholesterol ◽  
Group Treatment ◽  
Methanolic Extract ◽  
Antidiabetic Activity ◽  
Diabetic Mice ◽  
Leaf Extracts ◽  
Ms Analysis ◽  
Haemolytic Assay

Plants are well known in traditional herbal medicines for their hypoglycemic and hypolipidemic activities and are often used due to their accessibility, affordability, and corollary effects. Leptopus cordifolius has been reported to control diabetes in folkloric medicine, but no known scientific research has been conducted to assess the plausibility of this assertion. Therefore, the current study is aimed to investigate the antidiabetic and hypolipidemic effects of Leptopus cordifolius leaves in alloxan-induced diabetic mice. The antidiabetic and antihyperlipidemic evaluation was conducted in Swiss albino mice at doses of 150–250°mg/kg for 15°days. The blood glucose, total cholesterol, triglyceride, LDL, HDL, creatinine, ALP, SGPT, and SGOT levels were estimated according to standard procedures. Phytochemicals of leaves were analyzed using GC-MS analysis. Enzymatic antioxidant activity of the plant was investigated spectrophotometrically by carrying out superoxide dismutase, peroxidase, and catalase assays. The membrane stabilization potential of L. cordifolius leaf extracts was carried out using an in vitro haemolytic assay. The results revealed a dose response effect with the methanolic extract of L. cordifolius which had significant antihyperglycemic effects at 150–250°mg/kg in alloxan treated mice, although less than the positive control (glibenclamide). Hyperlipidemic activity was significant at 250 mg/kg. The biochemical parameters, such as total cholesterol, triglyceride, LDL, HDL, creatinine, ALP, SGPT, and SGOT, were significantly improved (p < 0.01) by the methanolic extract of 250 mg/kg compared to the diabetic group. Treatment for 15 days showed significant elevation (p < 0.01) of antioxidant enzymes. GC-MS analysis provided tentative identifications of 52 compounds in the methanolic extract of L. cordifolius, of which 12 compounds have reported antidiabetic activity. In conclusion, methanolic extract of L. cordifolius of 150 and 250°mg/kg body weight showed significant antidiabetic and antihyperlipidemic activities in alloxan-induced diabetic mice and, with further work, has the potential to be used to manage blood glucose and cholesterol levels.

scholarly journals Protective effects of Equisetum arvense methanolic extract on sperm characteristics and in vitro fertilization potential in experimental diabetic mice: An experimental study

2020 ◽  
Author(s):  
Mehrsa Fajri ◽  
Abbas Ahmadi ◽  
Rajabali Sadrkhanlou
Keyword(s):  
In Vitro Fertilization ◽  
Methanolic Extract ◽  
Sperm Quality ◽  
Diabetic Group ◽  
Key Words Diabetes ◽  
Protective Effects ◽  
Diabetic Mice ◽  
Equisetum Arvense ◽  
Vitro Fertilization

Background: Diabetes mellitus is a metabolic disorder characterized by impaired insulin secretion or the inability of tissues to respond to insulin. This disease can damage the testis and reduce semen quality. Therefore, it can impair the potential for male fertility. Different herbal therapeutic treatments have been used to control diabetes and its complications. Objective: This study aimed to evaluate the effects of streptozotocin-induced diabetes on sperm and in vitro fertilization (IVF) potential and investigate the protective effects of Equisetum arvense methanolic extract on diabetic mice. Materials and Methods: Twenty-four adult male mice were divided into four groups: control-sham, diabetic, diabetic + Equisetum extract (250 mg/kg), and diabetic + Equisetum extract (500 mg/kg). After 45 days, sperm samples were collected from the cauda epididymis to evaluate the characteristics of sperm and the IVF potential. Results: Sperm motility and viability were increased remarkably (p≤ 0.001) in the treated groups compared with the non-treated diabetic group. The decrease in sperm count in the diabetic group compared with the treated groups was not significant. Moreover, the percentage of sperm with DNA damage, nuclear immaturity, and abnormal morphology was decreased significantly (p≤ 0.001) in the treated groups compared with the diabetic group. The treated animals exhibited remarkably higher fertilization rates and a higher percentage of fertilized oocytes that developed toward the blastocyst stage compared with the non-treated diabetic group (p≤ 0.001). Conclusion: The methanolic extract of the Equisetum arvense inhibited diabetes-induced detrimental effects on sperm quality and fertilization rate, which may have been associated with hypoglycemic and antioxidative activities in this plant. Key words: Diabetes, Equisetum, Sperm, Streptozotocin, Mice.

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