Objectives Love trauma syndrome is a common occurrence among college students that can result to psychological and educational problems. The current research supposed to illustrate the role of personality traits, early maladaptive Schemas and spiritual health in prediction of love trauma syndrome. Methods The present study was a correlational research based on structural equation modeling (SEM). The population includes all students of Tehran universities who suffers love trauma syndrome. 500 subjects were selected by cluster random sampling and answered the Love Trauma Inventory(LTI), Hexaco Personality Questionnaire(HEXACO), Young Schema Questionnaire(YSQ-SF) and Spirituality Index of Well-Being(SIWB). Data analysis was performed by structural equation modeling using LISREL software. Results SEM model showed a root mean square error of 0.043 which indicate good model fit. Conclusion The provided model for predicting LT syndrome was a good fitting model. Personality traits, early maladaptive schemes, and the spiritual health could predict LT syndrome. Extraversion, excitement, humility/honesty, sacrifice, abandonment/ instability and life plan are the best predictors for intensity of love trauma syndrome.