The Prognostic Value of the Perioperative Systemic Inflammation Score for Patients With Advanced Gastric Cancer

Background: Curative treatment for gastric cancer (GC) comprising gastrectomy with systematic lymph node dissection can result in postoperative complications. Postoperative pneumonia is sometimes fatal, like surgery-related complications such as anastomotic leakage. In this retrospective study, we analyzed a multi-institutional collaborative dataset with the aim of identifying predictors of postgastrectomy pneumonia. Methods: From a retrospective database of 3,484 patients who had undergone gastrectomy for GC at nine Japanese institutions between 2010 and 2014, 1,415 patients who met all eligibility criteria were identified as eligible for analysis. Predictive values of 31 candidate variables for postoperative pneumonia were assessed. Results: Forty-two patients (3.0%) had grade II or higher postoperative pneumonia. Preoperative systemic inflammation score (SIS) had the greatest area under the curve (0.655) for predicting postoperative pneumonia (optimal cutoff value = 2). The odds ratio (OR) of high SISs associated with postoperative pneumonia was 3.10 (95% confidence interval [CI], 1.54–6.07; p < 0.001). Multivariate binomial logistic analysis identified high SIS as an independent risk factor for postoperative pneumonia (OR, 2.31; 95% CI, 1.19–4.48; p = 0.013). A forest plot revealed that ORs of high SISs were highest in female patients. Conclusions: Our findings indicate that the preoperative SIS may serve as a simple predictor of postgastrectomy pneumonia, assisting physicians’ efforts to take preventive measures against this complication.

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Systemic inflammation score is a prognostic marker after curative resection in gastric cancer

ANZ Journal of Surgery ◽

10.1111/ans.15103 ◽

2019 ◽

Vol 89 (4) ◽

pp. 377-382 ◽

Cited By ~ 4

Author(s):

Mingzhe Ma ◽

Mingzhe Weng ◽

Fei Chen ◽

Yiren Hu ◽

Jianguo Lai ◽

...

Keyword(s):

Gastric Cancer ◽

Prognostic Marker ◽

Systemic Inflammation ◽

Curative Resection ◽

Systemic Inflammation Score ◽

Inflammation Score

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Prognostic value of systemic inflammation score in patients with hepatocellular carcinoma after hepatectomy

Oncotarget ◽

10.18632/oncotarget.18121 ◽

2017 ◽

Vol 8 (45) ◽

pp. 79366-79375 ◽

Cited By ~ 9

Author(s):

Shiming Shi ◽

Qing Chen ◽

Luxi Ye ◽

Dan Yin ◽

Xuedong Li ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Systemic Inflammation ◽

Prognostic Value ◽

Systemic Inflammation Score ◽

Inflammation Score

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Prognostic value of fibrosis ratio in metastatic lymph nodes of node-positive advanced gastric cancer

Medicine ◽

10.1097/md.0000000000009703 ◽

2018 ◽

Vol 97 (3) ◽

pp. e9703 ◽

Cited By ~ 1

Author(s):

Soon Auck Hong ◽

Myoung Won Son ◽

Junhun Cho ◽

Chung Hun Lee ◽

Si-Hyeong Jang ◽

...

Keyword(s):

Gastric Cancer ◽

Lymph Nodes ◽

Advanced Gastric Cancer ◽

Prognostic Value ◽

Metastatic Lymph Nodes ◽

Node Positive ◽

Metastatic Lymph

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Prognostic value of immunity change after treatment for patients with locally advanced gastric cancer: a retrospective study

10.21203/rs.2.14629/v1 ◽

2019 ◽

Author(s):

Ke-Shen Wang ◽

Cheng-Cheng Ma ◽

Yan-Xian Ren ◽

Zhi-Jian Ma ◽

Shu-Ze Zhang ◽

...

Keyword(s):

Gastric Cancer ◽

Advanced Gastric Cancer ◽

Prognostic Value ◽

Immune Status ◽

Dynamic Change ◽

Locally Advanced ◽

Prognostic Significance ◽

Status Change ◽

Operating Characteristics ◽

Locally Advanced Gastric Cancer

Abstract Background Although the preoperative immune status is associated with the prognosis in some tumors, less is known about the prognostic significance of immune status change during the treatment of patients with locally advanced gastric cancer (LAGC).Methods The records of 210 patients with LAGC were retrospectively analysed. The pre-, and post-treatment (after gastrectomy and three cycles of chemotherapy) values of lymphocyte-to-monocyte ratio (LMR) and change of LMR (cLMR) were evaluated. A novel immunity change score (ICS) incorporated both preoperative LMR (pLMR) and cLMR was developed and its prognostic value was evaluated.Results cLMR was an independent predictor and patients with cLMR >1 after treatment had a favorable survival compared with the others (51 vs 31 months, P < 0.001). Based on the cLMR and pLMR, the ICS was defined as follows: ICS=1 (pLMR≤4.53 and cLMR≤1); ICS=2 (pLMR≤4.53 and cLMR>1, or pLMR>4.53 and cLMR≤1); and ICS=3 (pLMR>4.53 and cLMR>1). Multivariate analysis revealed that the ICS was a significant independent biomarker ( P < 0.001). The performances of ICS in terms of the time-dependent receiver operating characteristics (t-ROC) curve and concordance index (C-index) analysis were better than those of pLMR and cLMR. Then we established a nomogram incorporated the ICS, CEA, and TNM stage to predict the 3- and 5- year survival. Decision curve analysis and calibration curve demonstrated that the nomogram was clinically useful.Conclusion The dynamic change of immune status is significantly associated with prognosis for LAGC patients. Combining with the cLMR and pLMR could improve the prognostication for LAGC patients.

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Changes in neutrophil /lymphocyte ratio and platelet count after chemotherapy correlate with cheomtherapy response and predicition of prognosis in patients with advanced gastric cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e16030 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e16030-e16030

Author(s):

Yibing Liu ◽

Qingju Meng ◽

Zhiguo Zhou ◽

Li Jing

Keyword(s):

Gastric Cancer ◽

Platelet Count ◽

Advanced Gastric Cancer ◽

Prognostic Value ◽

Receiver Operating Curve ◽

Chemotherapy Response ◽

Tubular Adenocarcinoma ◽

Type I ◽

Lymphocyte Ratio ◽

Pathological Type

e16030 Background: The aim of the study was to investigate the predictive value of neutrophil to lymphocyte ratio(NLR) and platelet count(PLT) in the prediction of chemotherapy response and prognosis in patients with advanced gastric cancer. Methods: In this retrospective study, a total of 260 advanced gastric cancer patients were analyzed and the correlation between NLR, PLT and overall survival (OS) were investigated. The receiver operating curve (ROC) was drawn to determine the optimal critical value of NLR. These cases were included and separated into different groups according to the median values of NLR or PLT. Results: Low baseline NLR level correlated with improved clinicopathological characteristics, including organ-free metastasis, Borramn type I and II, tubular adenocarcinoma and papillary carcinoma. Low baseline PLT level also associated with Borramn classification. Alterations in the NLR and PLT levels were associated with therapeutic efficacy and prognosis. The patients who remained in or switched to the low NLR level had an improved objective response rate(ORR), disease control rate(DCR) and survival ratios. The patients who remained in or switched to the low PLT level had an improved DCR. Univariate analyses showed that pathological type, Borramn typing, changes of NLR, and efficacy of chemotherapy were significant predictors of OS. Multivariate analyses showed that pathological type and efficacy evaluation were independent prognostic factor. Conclusions: This study demonstrated that the changes of NLR and PLT following chemotherapy can predict the chemotherapy results in patients with advanced gastric cancer. But, baseline NLR and PLT level haven’t prognostic value in patients with advanced gastric cancer. However, pathological types and the results of the first therapeutic evaluation could have prognostic value in patients with advanced gastric cancer.

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