On the histological structure of Kaposi’s sarcoma

Objective: to study the histological structure of various types of Kaposi’s sarcoma and the morphogenetic potentials of vascular cells in the tumor growth.Materials and methods: results of the histological examination of Kaposi’s sarcoma from 5 patients have been analyzed: biopsies of the skin and subcutaneous tissue from 3 HIV-infected patients (2 men and 1 woman) and 1 man, a participator of the liquidation (dosimetrist) of the consequences of the Chernobyl accident in 1986. The tumor nodes of the Kaposi’s sarcoma of the stomach, lymphatic mesenteric node and dura mater of a 41-year-old woman who had died aft er allogeneic kidney transplantation due to glomerulonephritis were also examined while the skin was intact. Histological preparations were stained with hematoxylin and eosin, picrofuchsin according to Van Gieson, alcian blue and impregnated with silver according to Bilshovsky.Results: it was confirmed that Kaposi’s sarcoma is the part of a multicentrally occurring viral lesion of the skin, subcutaneous tissue and internal organs caused by herpes infections of the 8th type on the background of immunosuppression. The entire process of tumor formation includes, besides the tumor growth, pre-tumor conditions (viral infection, chronic inflammation), and pre-tumor processes (intravascular neoplasia of low and high degree), which determining the diversity of the histological structure, clinical course, outcomes of neoplasms and complicates the correct diagnosis. The morphogenetic potentialities of endothelial and perithelial cells which make various variants of angiomatous structures, and also form spindle cell, myofibroblastic and fi broblastic components, are also important.Conclusions: the fifth, not yet described in the literature, variant of Kaposi’s sarcoma is highlighted - radiation, due to exposure of radiation energy.

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Human Chorionic Gonadotropin Inhibits Kaposi’s Sarcoma Associated Angiogenesis, Matrix Metalloprotease Activity, and Tumor Growth

Endocrinology ◽

10.1210/endo.143.8.8945 ◽

2002 ◽

Vol 143 (8) ◽

pp. 3114-3121 ◽

Cited By ~ 10

Author(s):

Ulrich Pfeffer ◽

Davide Bisacchi ◽

Monica Morini ◽

Roberto Benelli ◽

Simona Minghelli ◽

...

Keyword(s):

Tumor Growth ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Kaposi's Sarcoma ◽

Kaposi’S Sarcoma ◽

Matrix Metalloprotease ◽

Metalloprotease Activity

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Tumor Growth Dependent on Kaposi's Sarcoma-Derived Fibroblast Growth Factor Inhibited by Pentosan Polysulfate

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/83.10.716 ◽

1991 ◽

Vol 83 (10) ◽

pp. 716-720 ◽

Cited By ~ 74

Author(s):

A. Wellstein ◽

G. Zugmaier ◽

J. A. Califano ◽

F. Kern ◽

S. Paik ◽

...

Keyword(s):

Growth Factor ◽

Tumor Growth ◽

Fibroblast Growth Factor ◽

Kaposi's Sarcoma ◽

Kaposi’S Sarcoma ◽

Fibroblast Growth ◽

Pentosan Polysulfate

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Pulmonary Kaposi’s sarcoma in a female patient: Case report

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.62.05.395 ◽

2016 ◽

Vol 62 (5) ◽

pp. 395-398

Author(s):

Natacha Calheiros de Lima Petribu ◽

Mayana Silva Cisneiros ◽

Glauber Barbosa de Carvalho ◽

Lucyana de Melo Baptista

Keyword(s):

Female Patient ◽

Kaposi's Sarcoma ◽

Subcutaneous Tissue ◽

Ground Glass Opacity ◽

Kaposi’S Sarcoma ◽

Skin Lesions ◽

Ground Glass ◽

Adult Males ◽

Cutaneous Form ◽

Cd4 Lymphocyte

SUMMARY Kaposi’s sarcoma (KS) is a multicentric lymphoproliferative malignancy. Most of the time this tumor is confined to the skin and subcutaneous tissue, but it can present with widespread visceral involvement, such as in the lung. Pulmonary KS is the most frequent form in young adult males, in a ratio of 15:1. The disease usually affects individuals with low CD4 lymphocyte counts (<150-200 cells/mm3). We report a case of a female patient aged 35 years, with the presence of skin lesions, self-limiting episodes of diarrhea and weight loss of 15 kg for nearly 9 months, progressing to persistent fever. AIDS was diagnosed and biopsy of the lesions revealed Kaposi’s sarcoma. Computed tomography of the chest showed peribronchovascular thickening, areas of ground glass opacity, condensations with air bronchograms surrounded by ground glass opacity (halo sign) and bilateral pleural effusion. The diagnosis of pulmonary KS is still a challenge, especially due to the occurrence of other opportunistic diseases that may also occur concurrently. Therefore, suspecting this diagnosis based on clinical and laboratory manifestations, and even more with CT findings, is fundamental, especially in patients who already have the cutaneous form of the disease.

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Diagnostic and Therapeutic Approach to HIVKaposi’s Sarcoma Patients-Case Report

Balkan Journal of Dental Medicine ◽

10.2478/bjdm-2019-0030 ◽

2019 ◽

Vol 23 (3) ◽

pp. 167-171

Author(s):

Chari Charis ◽

Dalampiras Antonios ◽

Margianou Ioanna ◽

Zarampouka Katerina ◽

Michalopoulos Antonios

Keyword(s):

Case Report ◽

Oral Cavity ◽

Kaposi's Sarcoma ◽

Rna Virus ◽

Correct Diagnosis ◽

Kaposi’S Sarcoma ◽

Immune Deficiency Syndrome ◽

Vascular Tumor ◽

Skin Lesions ◽

University Hospital

Summary Background/Aim: The Acquired Immune Deficiency Syndrome (AIDS) is an immunologic entity, which is due to an RNA virus. AIDS is relatively easy transmitted and has a poor prognosis. The main mechanism of this Syndrome is characterized by the destruction and diminishing of T4 lymphocytes or helper/suppressor T-cells. Kaposi’s sarcoma is a neoplasm due to human herpes HHV-8. Kaposi’s sarcoma is one of the entities that determines the disease of AIDS. Kaposi’s sarcoma appears as skin lesions and attacks the oral cavity and lymph nodes. Case report: A male patient, with HIV-syndrome, was referred to the Special Infection Clinic of the University Hospital with a chief complaint of having two lesions, in the oral cavity and in the right ear. The histological report revealed the diagnosis of vascular tumor having morphological and immuno-histochemical characteristics compatible with Kaposi’s sarcoma. Conclusions: The doctor must be suspicious when lesions are observed, particularly in the oral cavity. A biopsy must be taken in order to obtain the correct diagnosis and examine the possibility of the presence of Kaposi’s sarcoma or AIDS.

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The state of cancer care in Russia: malignant tumors of the skin (C44). Prevalence, index of accuracy, localization and histological structure. Population-based research at the federal district level

Problems in oncology ◽

10.37469/0507-3758-2021-67-5-635-639 ◽

2021 ◽

Vol 67 (5) ◽

pp. 635-639

Author(s):

Vahtang Merabishvili

Keyword(s):

Russian Federation ◽

Kaposi's Sarcoma ◽

Malignant Tumors ◽

Kaposi’S Sarcoma ◽

Federal District ◽

Cancer Registries ◽

Histological Structure ◽

Visual Localization ◽

Prevalence Index ◽

The Russian Federation

Malignant tumors of the skin — visual localization, with a low mortality rate. Despite the fact that malignant tumors of the skin (C44) belong to the group of malignant tumors in many countries, cancer registries did not keep its records, the same attitude to this tumor was developed by doctors, which makes it difficult to conduct comparative studies between countries. When selecting data for the analysis of the prevalence of malignant tumors of the skin, in addition to the heading C44, a part of the heading ICD-10 — C46 — Kaposi's sarcoma — its part C46.0 — Kaposi's sarcoma of the skin is added. In many cases, it is not taken into account, due to its extremely rare occurrence, which does not have any practical impact on all the main analytical indicators. The purpose of this study is: for the first time in Russia, to consider not only the patterns of the prevalence of malignant tumors of the skin, but also to study the specifics of the localization and histological structure of this tumor localization, based on the newly created database of the population cancer Registry (PCR) of the North-Western Federal District of the Russian Federation (NWFD of the Russian Federation).

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A Series of Patients with Kaposi Sarcoma (Mediterranean/Classical Type): Case Presentations and Short Update on Pathogenesis and Treatment

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2018.354 ◽

2018 ◽

Vol 6 (9) ◽

pp. 1688-1693

Author(s):

Ivanka Temelkova ◽

Michael Tronnier ◽

Ivan Terziev ◽

Uwe Wollina ◽

Ilia Lozev ◽

...

Keyword(s):

Kaposi's Sarcoma ◽

Histopathological Examination ◽

Treatment Options ◽

Correct Diagnosis ◽

Local Treatment ◽

Kaposi Sarcoma ◽

Kaposi’S Sarcoma ◽

Classical Type ◽

Wide Range ◽

Two Samples

BACKGROUND: Kaposi’s sarcoma was first described in 1872 by Moritz Kaposi. To date, it is considered a malignant disease is originating from the endothelial cells of the lymphatic vessels believed to be infected with HHV-8. The current classification defines four major epidemiological forms of Kaposi’s sarcoma: classical, endemic, AIDS-associated, and iatrogenic. CASE REPORT: A 90-year-old male is presented with multiple plaques- and tumour-shaped brown-violet formations located on an erythematous-livid base in the area of both feet and both shanks. Two samples were taken from the lesions on the skin of the shanks, with histopathological examination and the subsequent immunohistochemistry showing Kaposi’s sarcoma. CONCLUSIONS: Kaposi sarcoma is a disease that causes difficulties both in diagnostic and therapeutic respect. The only sure way to determine the correct diagnosis is immunohistochemical staining with the anti-HHV8 antibody. Despite the wide range of systematic and local treatment options, there is still no unified algorithm and a unified strategy for the treatment of Kaposi’s sarcoma.

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Stewart–Bluefarb syndrome: Report of five cases and a review of literature

Phlebology The Journal of Venous Disease ◽

10.1177/0268355514548090 ◽

2014 ◽

Vol 30 (8) ◽

pp. 505-514 ◽

Cited By ~ 7

Author(s):

K Parsi ◽

AA O’Connor ◽

L Bester

Keyword(s):

Chronic Venous Insufficiency ◽

Kaposi's Sarcoma ◽

Venous Insufficiency ◽

Venous Malformation ◽

Correct Diagnosis ◽

Case Series ◽

Duplex Ultrasound ◽

Kaposi’S Sarcoma ◽

Cutaneous Manifestations ◽

Venous Fistula

Stewart–Bluefarb syndrome is a rare angioproliferative disorder characterised by acroangiodermatitis associated with an underlying arteriovenous shunt. This condition should be differentiated from acroangiodermatitis of Mali classically described in association with chronic venous insufficiency. Patients with Stewart–Bluefarb syndrome typically present with lower leg pigmented macules, papules and plaques that can coalesce to form larger confluent patches of pigmentation. Recognition of Stewart–Bluefarb syndrome may be difficult or delayed as the cutaneous manifestations may resemble a variety of other dermatological conditions. Most commonly, acroangiodermatitis may be confused with Kaposi’s sarcoma and the condition is often referred to as ‘Pseudo-Kaposi’s sarcoma’. Acroangiodermatitis may also resemble or coexist with pigmentation of chronic venous insufficiency. As seen in this report, acroangiodermatitis may also be clinically confused with the ‘cavernous’ form of a capillary malformation. Here, we describe five patients with Stewart–Bluefarb syndrome. In one female and two male patients the diagnosis was delayed as the acroangiodermatitis closely resembled other conditions. All underlying arterio-venous communications were initially diagnosed on duplex ultrasound and confirmed with magnetic resonance angiography. Four patients were found to have a congenital arterio-venous malformation while one was diagnosed with a post-thrombotic arterio-venous fistula. Management included observation and intervention using a variety of techniques including percutaneous or trans-catheter embolisation, endovenous laser, radiofrequency ablation and foam ultrasound guided sclerotherapy. This case series highlights the challenges involved in the diagnosis and management of Stewart–Bluefarb syndrome. Given the local and systemic sequelae of high flow shunts, correct diagnosis and early detection of the underlying arterio-venous abnormality is crucial in the long-term management of these patients and in preventing the associated complications.

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