scholarly journals Deep Digital Phenotyping and Digital Twins for Precision Health: Time to Dig Deeper

10.2196/16770 ◽  
2020 ◽  
Vol 22 (3) ◽  
pp. e16770 ◽  
Author(s):  
Guy Fagherazzi

This viewpoint describes the urgent need for more large-scale, deep digital phenotyping to advance toward precision health. It describes why and how to combine real-world digital data with clinical data and omics features to identify someone’s digital twin, and how to finally enter the era of patient-centered care and modify the way we view disease management and prevention.

2019 ◽  
Author(s):  
Guy Fagherazzi

UNSTRUCTURED This viewpoint describes the urgent need for more large-scale, deep digital phenotyping to advance toward precision health. It describes why and how to combine real-world digital data with clinical data and omics features to identify someone’s digital twin, and how to finally enter the era of patient-centered care and modify the way we view disease management and prevention.


2018 ◽  
Author(s):  
Nilmini Wickramasinghe ◽  
Blooma John ◽  
Joey George ◽  
Doug Vogel

BACKGROUND The World Health Organization notes that diabetes, a chronic disease, is a silent epidemic, and by 2020 there will be a 54% rise in the total number of individuals diagnosed with this disease. These are alarming figures that have significant repercussions for the quality of life of individuals and their families as well as for the financial stress of health care systems globally. Early detection and proactive management of diabetes is essential. The Diamond solution provides diabetes self-management by enabling patients to send details about their blood sugar readings at specific times to their nominated care coordinator to receive recommendations for diet and exercise and insulin titration. OBJECTIVE The aim of the study was to assess the usability, acceptability, and fidelity of the Diamond diabetes monitoring device for patients with gestational diabetes mellitus (GDM). Specifically assessed were (1) patient compliance, (2) patient satisfaction, (3) level of glycemic control achieved, and (4) health professional satisfaction. METHODS Using a design science research perspective, the Diamond diabetes monitoring device solution was adapted to the Australian health care environment. Once the solution was deemed fit for purpose by the director of the OB/GYN clinical institute and on securing all relevant ethics approvals, a 2-period 2-arm nonblinded crossover clinical trial was conducted for 8 weeks total time with crossover at 4 weeks to establish proof of concept, usability, and fidelity. The patient perspective was assessed by using structured questionnaires at 4 specific stages of the project, while the clinician perspective was captured via semistructured interviews and unstructured questionnaires. RESULTS The 10 patients studied reported preferring standard care with the technology solution to standard care alone. Further, all clinicians involved concurred that the technology solution greatly assisted their ability to provide higher value patient-centered care. They also noted that it was extremely helpful for assisting in systematically monitoring glucose levels and any/all changes and trends. CONCLUSIONS Based on these initial findings, we offer a holistic pervasive approach to enable the achievement of value-based, patient-centered care in chronic disease management. Key lessons include the importance when designing such solutions to focus on the two primary user groups (patients and clinicians).


2019 ◽  
Vol 35 (S1) ◽  
pp. 56-56
Author(s):  
Orna Tal ◽  
Inbal Tal

IntroductionClassic health technology assessment (HTA) is based on safety, efficacy, and costs. However, in the dynamic world of medicine, “real-world” experience is used to improve HTA. Aggregating evidence is a constant challenge. Physicians are traditionally trained in professionalism (knowledge and skills) and compassion, concentrating on the patient and disease rather than the technology. Currently, medical education also emphasizes quality of care by promoting standardization, and reducing mistakes by root cause analysis. We aimed to integrate the key parameters of safety, effectiveness, quality measures, economic aspects, and assessment guidelines for real-world experience in medical education.MethodsA group of medical students participated in a targeted HTA-orientated education program, which focused on the identification of challenges and barriers in the adoption of health technologies, and then completed a structured survey.ResultsThe program included 243 students. They raised four major emerging challenges: (i) to initiate a culture of quality and HTA-targeted perception for individual physicians; (ii) to better understand the role of different stakeholders in the health system; (iii) to be exposed to considerations of budget allocation; and (iv) to incorporate patient preferences, expectations, and engagement so that patient-centered care becomes a critical part of HTA.ConclusionsIncorporating values of HTA-targeted quality at an early stage of medical education, while future physicians are developing their professional identity, may create a professional, quality-focused leadership group in health care. The understanding and implementation of these “new” dimensions may serve as a platform for building smart capability to ensure better decision making processes among caregivers and medical managers.


Pharmacy ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 164
Author(s):  
Alexandre Chan ◽  
Melanie D. Joe ◽  
Jan D. Hirsch

Despite numerous challenges in relation to being a recently established school, the University of California, Irvine (UCI) School of Pharmacy and Pharmaceutical Sciences (SPPS), similar to many schools of pharmacy in the United States, was highly committed to supporting the rollout of COVID-19 vaccines. UCI SPPS and our affiliated UCI Medical Center (UCIMC) Pharmacy Department partnered to spearhead the pharmacy element of a large-scale COVID-19 vaccination clinic on campus for both employees and the community. Three key initiatives were established in order to overcome the obstacles we faced in the large-scale roll out of COVID-19 vaccines: (1) forging new collaborations within the pharmacy team, (2) leveraging interprofessional education and practice, and (3) raising awareness of the pharmacists’ role. Our response to the COVID-19 vaccines at UCI was a tangible, visible model that demonstrated that, while we continue to embrace our role in team-based, patient-centered care, it is also important for us to step up and lead the profession. Additionally, this vaccine rollout experience is a teachable moment for our communities and our health professional partners as we continue to march forward as one voice to serve the American public.


2021 ◽  
Vol 12 ◽  
Author(s):  
Isabel Voigt ◽  
Hernan Inojosa ◽  
Anja Dillenseger ◽  
Rocco Haase ◽  
Katja Akgün ◽  
...  

An individualized innovative disease management is of great importance for people with multiple sclerosis (pwMS) to cope with the complexity of this chronic, multidimensional disease. However, an individual state of the art strategy, with precise adjustment to the patient’s characteristics, is still far from being part of the everyday care of pwMS. The development of digital twins could decisively advance the necessary implementation of an individualized innovative management of MS. Through artificial intelligence-based analysis of several disease parameters – including clinical and para-clinical outcomes, multi-omics, biomarkers, patient-related data, information about the patient’s life circumstances and plans, and medical procedures – a digital twin paired to the patient’s characteristic can be created, enabling healthcare professionals to handle large amounts of patient data. This can contribute to a more personalized and effective care by integrating data from multiple sources in a standardized manner, implementing individualized clinical pathways, supporting physician-patient communication and facilitating a shared decision-making. With a clear display of pre-analyzed patient data on a dashboard, patient participation and individualized clinical decisions as well as the prediction of disease progression and treatment simulation could become possible. In this review, we focus on the advantages, challenges and practical aspects of digital twins in the management of MS. We discuss the use of digital twins for MS as a revolutionary tool to improve diagnosis, monitoring and therapy refining patients’ well-being, saving economic costs, and enabling prevention of disease progression. Digital twins will help make precision medicine and patient-centered care a reality in everyday life.


2012 ◽  
Vol 88 (2) ◽  
pp. 170-176 ◽  
Author(s):  
Catherine Hudon ◽  
Martin Fortin ◽  
Jeannie Haggerty ◽  
Christine Loignon ◽  
Mireille Lambert ◽  
...  

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Barbara G. Bokhour ◽  
Gemmae M. Fix ◽  
Nora M. Mueller ◽  
Anna M. Barker ◽  
Sherri L. Lavela ◽  
...  

2018 ◽  
Vol 2 (3) ◽  
pp. 183-185 ◽  
Author(s):  
Russell E. Glasgow ◽  
Bethany M. Kwan ◽  
Daniel D. Matlock

Precision health and big data approaches have great potential, yet such benefits will be realized only when social and behavioral determinants of health and patient preferences are combined with genomic information. Literature review and co-author experiences informed this commentary. Validated health behavior, mental health, and patient preference measures were collected and summarized in real time. Integration of such data into existing data sets will advance precision health, patient-centered care, research, and policy.


2021 ◽  
Author(s):  
Ambika Agarwal

[Para. 1 of Introduction] Dentistry is an amalgamation of many roles; they are providers of care, innovators and lifelong guides to a perfect smile. By pursuing a career in dentistry, I hope to wear those many hats and provide compassionate and meaningful patient-centered care. During my high school career, I volunteered at a nursing home. Many of the seniors I worked with had trouble chewing and swallowing, were missing teeth, and had uncomfortable dentures. I realized how oral health could directly impact an individual’s quality of life. Teeth are simply irreplaceable; a lack thereof affects diet and nutrition, leading to deterioration of health. It can cause a loss of self-esteem and confidence. From this experience, I began looking into dentistry. My growing interest persuaded me to shadow my dentist, from whom I gained insight about a dentist’s role and how a practice operates.


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