scholarly journals Multiscale Biology of Cardiovascular Risk in Psoriasis: Protocol for a Case-Control Study

10.2196/28669 ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. e28669 ◽  
Author(s):  
Hannah Kaiser ◽  
Amanda Kvist-Hansen ◽  
Christine Becker ◽  
Xing Wang ◽  
Benjamin D McCauley ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Cardiovascular Risk ◽  
Systems Biology ◽  
Fdg Pet ◽  
Blood Samples ◽  
Pericardial Adipose Tissue ◽  
Pet Ct ◽  
Skin Biopsies ◽  
18F Fdg ◽  
Fdg Pet Ct

Background Patients with psoriasis have increased risk of cardiovascular disease (CVD) independent of traditional risk factors. The molecular mechanisms underlying the psoriasis-CVD connection are not fully understood. Advances in high-throughput molecular profiling technologies and computational analysis techniques offer new opportunities to improve the understanding of disease connections. Objective We aim to characterize the complexity of cardiovascular risk in patients with psoriasis by integrating deep phenotypic data with systems biology techniques to perform comprehensive multiomic analyses and construct network models of the two interacting diseases. Methods The study aims to include 120 adult patients with psoriasis (60 with prior atherosclerotic CVD and 60 without CVD). Half of the patients are already receiving systemic antipsoriatic treatment. All patients complete a questionnaire, and a medical interview is conducted to collect medical history and information on, for example, socioeconomics, mental health, diet, and physical exercise. Participants are examined clinically with assessment of the Psoriasis Area and Severity Index and undergo imaging by transthoracic echocardiography, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT), and carotid artery ultrasonography. Skin swabs are collected for analysis of microbiome metagenomics; skin biopsies and blood samples are collected for transcriptomic profiling by RNA sequencing; skin biopsies are collected for immunohistochemistry; plasma samples are collected for analyses of proteomics, lipidomics, and metabolomics; blood samples are collected for high-dimensional mass cytometry; and feces samples are collected for gut microbiome metagenomics. Bioinformatics and systems biology techniques are utilized to analyze the multiomic data and to integrate data into a network model of CVD in patients with psoriasis. Results Recruitment was completed in September 2020. Preliminary results of 18F-FDG-PET/CT data have recently been published, where vascular inflammation was reduced in the ascending aorta (P=.046) and aortic arch (P=.04) in patients treated with statins and was positively associated with inflammation in the visceral adipose tissue (P<.001), subcutaneous adipose tissue (P=.007), pericardial adipose tissue (P<.001), spleen (P=.001), and bone marrow (P<.001). Conclusions This systems biology approach with integration of multiomics and clinical data in patients with psoriasis with or without CVD is likely to provide novel insights into the biological mechanisms underlying these diseases and their interplay that can impact future treatment. International Registered Report Identifier (IRRID) DERR1-10.2196/28669

Multi-scale biology of cardiovascular risk in psoriasis: protocol of a case-control study (Preprint)

2021 ◽  
Author(s):  
Hannah Kaiser ◽  
Amanda Kvist-Hansen ◽  
Christine Becker ◽  
Xing Wang ◽  
Benjamin McCauley ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Systems Biology ◽  
Fdg Pet ◽  
Molecular Mechanisms ◽  
Blood Samples ◽  
Increased Risk ◽  
Pet Ct ◽  
Skin Biopsies ◽  
18F Fdg ◽  
Fdg Pet Ct

BACKGROUND Patients with psoriasis have increased risk of cardiovascular disease (CVD) independent of traditional risk factors. The molecular mechanisms underlying the psoriasis-CVD connection are not fully understood. Advances in high-throughput molecular profiling technologies and computational analysis techniques offer new opportunities to improve understanding of disease connections. OBJECTIVE In this study we aim to characterize the complexity of cardiovascular risk in patients with psoriasis by integrating deep phenotypic data with systems biology techniques to perform comprehensive multi-omic analyses and construct network models of the two interacting diseases. METHODS The study includes 120 adult patients with psoriasis, namely 60 with prior atherosclerotic CVD and 60 without CVD. Half of the patients are already receiving systemic anti-psoriatic treatment. All patients complete a questionnaire and a medical interview is conducted to collect medical history and information on, for example, socioeconomics, mental health, diet and physical exercise. Participants are examined clinically with assessment of Psoriasis Area and Severity Index and undergo imaging by transthoracic echocardiography, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) and carotid artery ultrasonography. Skin swabs are collected for analysis of microbiome metagenomics, skin biopsies and blood samples for transcriptomic profiling by RNA-sequencing, skin biopsies for immunohistochemistry, plasma samples for analyses of proteomics, lipidomics and metabolomics, blood samples for high dimensional mass cytometry, and feces samples for gut microbiome metagenomics, respectively. Bioinformatics and systems biology techniques are utilised to analyze the multi-omic data and to integrate data into a network model of CVD in patients with psoriasis. RESULTS Recruitment was completed in September 2020. A preliminary result of 18F-FDG-PET/CT data has recently been published. All analyses are underway, and results are expected to be published in 2021/22. CONCLUSIONS This system biology approach with integration of multi-omics and clinical data in patients with psoriasis with or without CVD is likely to provide novel insights into the biological mechanisms underlying these diseases and their interplay that can impact future treatment.

Glucose metabolism of visceral adipose tissue evaluated by 18F-FDG PET/CT reflects inflammatory status in metabolic syndrome

2020 ◽  
Vol 315 ◽  
pp. e227
Author(s):  
K. Pahk ◽  
H.W. Kwon ◽  
J.S. Eo ◽  
H.S. Seo ◽  
S. Kim
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Glucose Metabolism ◽  
Visceral Adipose Tissue ◽  
Fdg Pet ◽  
Inflammatory Status ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Visceral Adipose

scholarly journals The Relationship between Brown Adipose Tissue Activity and Neoplastic Status: an 18F-FDG PET/CT Study in the Tropics

2011 ◽  
Vol 10 (1) ◽  
pp. 238 ◽  
Author(s):  
Yung-Cheng Huang ◽  
Tai-Been Chen ◽  
Chien-Chin Hsu ◽  
Shau-Hsuan Li ◽  
Pei-Wen Wang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Pet ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg ◽  
Brown Adipose Tissue Activity ◽  
Fdg Pet Ct ◽  
The Tropics ◽  
The Relationship

scholarly journals Global brain glucose uptake on 18F-FDG-PET/CT is influenced by chronic cardiovascular risk

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Austin J. Borja ◽  
Emily C. Hancin ◽  
Vincent Zhang ◽  
Benjamin Koa ◽  
Abhijit Bhattaru ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Glucose Uptake ◽  
Fdg Pet ◽  
Brain Glucose ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Global Brain

18F-FDG PET/CT of Brown Adipose Tissue Hyperactivation Associated With Pregnancy and Paraganglioma

2017 ◽  
Vol 42 (12) ◽  
pp. 950-951 ◽  
Author(s):  
Anna Margherita Maffione ◽  
Lucia Rampin ◽  
Sotirios Chondrogiannis ◽  
Maria Cristina Marzola ◽  
Patrick M. Colletti ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Pet ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals 18F-FDG PET/CT Monitoring of  3 Agonist-Stimulated Brown Adipocyte Recruitment in White Adipose Tissue

2014 ◽  
Vol 56 (1) ◽  
pp. 153-158 ◽  
Author(s):  
J. W. Park ◽  
K.-H. Jung ◽  
J. H. Lee ◽  
C. H. T. Quach ◽  
S.-H. Moon ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Fdg Pet ◽  
Brown Adipocyte ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans

2020 ◽  
Vol 105 (7) ◽  
pp. 2203-2216 ◽  
Author(s):  
Oana C Kulterer ◽  
Laura Niederstaetter ◽  
Carsten T Herz ◽  
Alexander R Haug ◽  
Andrea Bileck ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Energy Expenditure ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Fdg Pet ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Abstract Background Accumulating evidence links brown adipose tissue (BAT) to increased cold-induced energy expenditure (CIEE) and regulation of lipid metabolism in humans. BAT has also been proposed as a novel source for biologically active lipid mediators including polyunsaturated fatty acids (PUFAs) and oxylipins. However, little is known about cold-mediated differences in energy expenditure and various lipid species between individuals with detectable BAT positive (BATpos) and those without BAT negative (BATneg). Methods Here we investigated a unique cohort of matched BATpos and BATneg individuals identified by 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography ([18F]-FDG PET/CT). BAT function, CIEE, and circulating oxylipins, were analyzed before and after short-term cold exposure using [18F]-FDG PET/CT, indirect calorimetry, and high-resolution mass spectrometry, respectively. Results We found that active BAT is the major determinant of CIEE since only BATpos individuals experienced significantly increased energy expenditure in response to cold. A single bout of moderate cold exposure resulted in the dissipation of an additional 20 kcal excess energy in BATpos but not in BATneg individuals. The presence of BAT was associated with a unique systemic PUFA and oxylipin profile characterized by increased levels of anti-inflammatory omega-3 fatty acids as well as cytochrome P450 products but decreased concentrations of some proinflammatory hydroxyeicosatetraenoic acids when compared with BATneg individuals. Notably, cold exposure raised circulating levels of various lipids, including the recently identified BAT-derived circulating factors (BATokines) DiHOME and 12-HEPE, only in BATpos individuals. Conclusions In summary, our data emphasize that BAT in humans is a major contributor toward cold-mediated energy dissipation and a critical organ in the regulation of the systemic lipid pool.

scholarly journals Quantitative assessment of brown adipose tissue metabolic activity and volume using 18F-FDG PET/CT and β3-adrenergic receptor activation

2011 ◽  
Vol 1 (1) ◽  
pp. 30 ◽  
Author(s):  
M Reza Mirbolooki ◽  
Cristian C Constantinescu ◽  
Min-Liang Pan ◽  
Jogeshwar Mukherjee
Keyword(s):  
Adipose Tissue ◽  
Metabolic Activity ◽  
Fdg Pet ◽  
Adrenergic Receptor ◽  
Quantitative Assessment ◽  
Receptor Activation ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Metabolic Activity of Visceral Adipose Tissue Is Associated with Metastatic Status of Lymph Nodes in Endometrial Cancer: A 18F-FDG PET/CT Study

2021 ◽  
Vol 19 (1) ◽  
pp. 92
Author(s):  
Kisoo Pahk ◽  
Ki-Jin Ryu ◽  
Chanmin Joung ◽  
Hyun Woo Kwon ◽  
Sanghoon Lee ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Endometrial Cancer ◽  
Lymph Nodes ◽  
Visceral Adipose Tissue ◽  
Metabolic Activity ◽  
Fdg Pet ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Visceral Adipose

Obesity contributes to increased cancer incidence and aggressiveness in patients with endometrial cancer. Inflamed metabolic activity of visceral adipose tissue (VAT) is regarded as a key underlying mechanism of adverse consequences of obesity. The aim of this study was to investigate the association between inflammatory metabolic activity of VAT evaluated by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and metastatic status of lymph nodes (LN) in patients with endometrial cancer. In total, 161 women with newly diagnosed endometrial cancer, who received preoperative 18F-FDG PET/CT, were enrolled. VAT inflammatory metabolic activity was defined as V/S ratio and measured from the maximum standardized uptake value (SUVmax) of VAT normalized to the SUVmax of subcutaneous adipose tissue (SAT). The positive LN metastasis group exhibited a significantly higher V/S ratio than the negative LN metastasis group. Systemic inflammatory surrogate markers including high sensitivity C-reactive protein, spleen SUVmax, and bone marrow SUVmax were also higher in the LN metastasis group than in the negative LN metastasis group, showing significant correlations with V/S ratio. In multivariate logistic regression analysis, V/S ratio was independently associated with LN metastasis. V/S ratio is independently associated with the LN metastasis status in patients with endometrial cancer. This finding could be useful as a potential surrogate marker of obesity-induced VAT inflammation associated with tumor aggressiveness.

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