scholarly journals Clinical Predictive Models for COVID-19: Systematic Study (Preprint)

2020 ◽  
Author(s):  
Patrick Schwab ◽  
August DuMont Schütte ◽  
Benedikt Dietz ◽  
Stefan Bauer
Keyword(s):  
Machine Learning ◽  
Health Care ◽  
Intensive Care ◽  
Clinical Data ◽  
Predictive Models ◽  
Health Care Systems ◽  
Gradient Boosting ◽  
Support Vector ◽  
Care Systems ◽  
To Receive

BACKGROUND COVID-19 is a rapidly emerging respiratory disease caused by SARS-CoV-2. Due to the rapid human-to-human transmission of SARS-CoV-2, many health care systems are at risk of exceeding their health care capacities, in particular in terms of SARS-CoV-2 tests, hospital and intensive care unit (ICU) beds, and mechanical ventilators. Predictive algorithms could potentially ease the strain on health care systems by identifying those who are most likely to receive a positive SARS-CoV-2 test, be hospitalized, or admitted to the ICU. OBJECTIVE The aim of this study is to develop, study, and evaluate clinical predictive models that estimate, using machine learning and based on routinely collected clinical data, which patients are likely to receive a positive SARS-CoV-2 test or require hospitalization or intensive care. METHODS Using a systematic approach to model development and optimization, we trained and compared various types of machine learning models, including logistic regression, neural networks, support vector machines, random forests, and gradient boosting. To evaluate the developed models, we performed a retrospective evaluation on demographic, clinical, and blood analysis data from a cohort of 5644 patients. In addition, we determined which clinical features were predictive to what degree for each of the aforementioned clinical tasks using causal explanations. RESULTS Our experimental results indicate that our predictive models identified patients that test positive for SARS-CoV-2 a priori at a sensitivity of 75% (95% CI 67%-81%) and a specificity of 49% (95% CI 46%-51%), patients who are SARS-CoV-2 positive that require hospitalization with 0.92 area under the receiver operator characteristic curve (AUC; 95% CI 0.81-0.98), and patients who are SARS-CoV-2 positive that require critical care with 0.98 AUC (95% CI 0.95-1.00). CONCLUSIONS Our results indicate that predictive models trained on routinely collected clinical data could be used to predict clinical pathways for COVID-19 and, therefore, help inform care and prioritize resources.

scholarly journals Clinical Predictive Models for COVID-19: Systematic Study

10.2196/21439 ◽  
2020 ◽  
Vol 22 (10) ◽  
pp. e21439 ◽  
Author(s):  
Patrick Schwab ◽  
August DuMont Schütte ◽  
Benedikt Dietz ◽  
Stefan Bauer
Keyword(s):  
Machine Learning ◽  
Health Care ◽  
Intensive Care ◽  
Clinical Data ◽  
Predictive Models ◽  
Health Care Systems ◽  
Gradient Boosting ◽  
Support Vector ◽  
Care Systems ◽  
To Receive

Background COVID-19 is a rapidly emerging respiratory disease caused by SARS-CoV-2. Due to the rapid human-to-human transmission of SARS-CoV-2, many health care systems are at risk of exceeding their health care capacities, in particular in terms of SARS-CoV-2 tests, hospital and intensive care unit (ICU) beds, and mechanical ventilators. Predictive algorithms could potentially ease the strain on health care systems by identifying those who are most likely to receive a positive SARS-CoV-2 test, be hospitalized, or admitted to the ICU. Objective The aim of this study is to develop, study, and evaluate clinical predictive models that estimate, using machine learning and based on routinely collected clinical data, which patients are likely to receive a positive SARS-CoV-2 test or require hospitalization or intensive care. Methods Using a systematic approach to model development and optimization, we trained and compared various types of machine learning models, including logistic regression, neural networks, support vector machines, random forests, and gradient boosting. To evaluate the developed models, we performed a retrospective evaluation on demographic, clinical, and blood analysis data from a cohort of 5644 patients. In addition, we determined which clinical features were predictive to what degree for each of the aforementioned clinical tasks using causal explanations. Results Our experimental results indicate that our predictive models identified patients that test positive for SARS-CoV-2 a priori at a sensitivity of 75% (95% CI 67%-81%) and a specificity of 49% (95% CI 46%-51%), patients who are SARS-CoV-2 positive that require hospitalization with 0.92 area under the receiver operator characteristic curve (AUC; 95% CI 0.81-0.98), and patients who are SARS-CoV-2 positive that require critical care with 0.98 AUC (95% CI 0.95-1.00). Conclusions Our results indicate that predictive models trained on routinely collected clinical data could be used to predict clinical pathways for COVID-19 and, therefore, help inform care and prioritize resources.

scholarly journals A Comprehensive Study of Artificial Intelligence and Machine Learning Approaches in Confronting the Coronavirus (COVID-19) Pandemic

2021 ◽  
pp. 002073142110174
Author(s):  
Md Mijanur Rahman ◽  
Fatema Khatun ◽  
Ashik Uzzaman ◽  
Sadia Islam Sami ◽  
Md Al-Amin Bhuiyan ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Health Care ◽  
Language Processing ◽  
Probabilistic Models ◽  
Health Care Systems ◽  
Learning Approaches ◽  
Care Systems ◽  
Novel Coronavirus ◽  
Comprehensive Study

The novel coronavirus disease (COVID-19) has spread over 219 countries of the globe as a pandemic, creating alarming impacts on health care, socioeconomic environments, and international relationships. The principal objective of the study is to provide the current technological aspects of artificial intelligence (AI) and other relevant technologies and their implications for confronting COVID-19 and preventing the pandemic’s dreadful effects. This article presents AI approaches that have significant contributions in the fields of health care, then highlights and categorizes their applications in confronting COVID-19, such as detection and diagnosis, data analysis and treatment procedures, research and drug development, social control and services, and the prediction of outbreaks. The study addresses the link between the technologies and the epidemics as well as the potential impacts of technology in health care with the introduction of machine learning and natural language processing tools. It is expected that this comprehensive study will support researchers in modeling health care systems and drive further studies in advanced technologies. Finally, we propose future directions in research and conclude that persuasive AI strategies, probabilistic models, and supervised learning are required to tackle future pandemic challenges.

scholarly journals Challenges and Trends in Clinical Data Analytics

2020 ◽  
pp. 348-360
Keyword(s):  
Health Care ◽  
Data Analysis ◽  
Clinical Data ◽  
Data Analytics ◽  
Health Care Systems ◽  
Data Sets ◽  
Handwritten Documents ◽  
Healthcare Data ◽  
Clinical Data Analysis ◽  
Care Systems

:Today’s technological advancements facilitated the researcher in collecting and organizing various forms of healthcare data. Data is an integral part of health care analytics. Drug discovery for clinical data analytics forms an important breakthrough work in terms of computational approaches in health care systems. On the other hand, healthcare analysis provides better value for money. The health care data management is very challenging as 80% of the data is unstructured as it includes handwritten documents, images; computer-generated clinical reports such as MRI, ECG, city scan, etc. The paper aims at providing a summary of work carried out by scientists and researchers who worked in health care domains. More precisely the work focuses on clinical data analysis for the period 2013 to 2019. The organization of the work carried out is specifically with concerned to data sets, Techniques, and Methods used, Tools adopted, Key Findings in clinical data analysis. The overall objective is to identify the current challenges, trends, and gaps in clinical data analysis. The pathway of the work is focused on carrying out on the bibliometric survey and summarization of the key findings in a novel way.

scholarly journals Otolaryngologists’ Role in Redeployment During the COVID-19 Pandemic: A Commentary

2020 ◽  
Vol 163 (1) ◽  
pp. 94-95 ◽  
Author(s):  
Taha Z. Shipchandler ◽  
B. Ryan Nesemeier ◽  
Cecelia E. Schmalbach ◽  
Jonathan Y. Ting
Keyword(s):  
Health Care ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Emergency Departments ◽  
Health Care Systems ◽  
Care Community ◽  
Care Systems ◽  
Hospital Wards

As otolaryngologists, we identify as subspecialists and fellowship-trained surgeons and may even identify as “super-subspecialists.” The likelihood of being redeployed and drawing from knowledge learned during our postgraduate year 1 training seemed exceedingly unlikely until physician resources became scarce in some health care systems during the COVID-19 pandemic. More now than ever, it is evident that our broad training is valuable in helping patients and allowing the otolaryngologist to meaningfully contribute to the larger health care community, especially while the majority (70%-95%) of elective care is delayed. With our skill set, otolaryngologists are poised to support various aspects of hospital wards, intensive care units, emergency departments, and beyond.

Machine Learning-Based Smart Health-care Systems

2021 ◽  
pp. 195-208
Author(s):  
Anil Kumar Swain ◽  
Bunil Kumar Balabantaray ◽  
Jitendra Kumar Rout
Keyword(s):  
Machine Learning ◽  
Health Care ◽  
Health Care Systems ◽  
Care Systems ◽  
Smart Health

scholarly journals Applying Machine Learning for Healthcare: A Case Study on Cervical Pain Assessment with Motion Capture

2020 ◽  
Vol 10 (17) ◽  
pp. 5942 ◽  
Author(s):  
Juan de la Torre ◽  
Javier Marin ◽  
Sergio Ilarri ◽  
Jose J. Marin
Keyword(s):  
Machine Learning ◽  
Predictive Models ◽  
Gradient Boosting ◽  
Support Vector ◽  
Cervical Pain ◽  
K Nearest Neighbors ◽  
Network Algorithms ◽  
Vector Machines ◽  
Real Scenario

Given the exponential availability of data in health centers and the massive sensorization that is expected, there is an increasing need to manage and analyze these data in an effective way. For this purpose, data mining (DM) and machine learning (ML) techniques would be helpful. However, due to the specific characteristics of the field of healthcare, a suitable DM and ML methodology adapted to these particularities is required. The applied methodology must structure the different stages needed for data-driven healthcare, from the acquisition of raw data to decision-making by clinicians, considering the specific requirements of this field. In this paper, we focus on a case study of cervical assessment, where the goal is to predict the potential presence of cervical pain in patients affected with whiplash diseases, which is important for example in insurance-related investigations. By analyzing in detail this case study in a real scenario, we show how taking care of those particularities enables the generation of reliable predictive models in the field of healthcare. Using a database of 302 samples, we have generated several predictive models, including logistic regression, support vector machines, k-nearest neighbors, gradient boosting, decision trees, random forest, and neural network algorithms. The results show that it is possible to reliably predict the presence of cervical pain (accuracy, precision, and recall above 90%). We expect that the procedure proposed to apply ML techniques in the field of healthcare will help technologists, researchers, and clinicians to create more objective systems that provide support to objectify the diagnosis, improve test treatment efficacy, and save resources.

scholarly journals Image and structured data analysis for prognostication of health outcomes in patients presenting to the Emergency Department during the COVID-19 pandemic

2021 ◽  
Author(s):  
Liam Butler ◽  
Ibrahim Karabayir ◽  
Mohammad Samie Tootooni ◽  
Majid Afshar ◽  
Ari Goldberg ◽  
...  
Keyword(s):  
Machine Learning ◽  
Emergency Department ◽  
Intensive Care ◽  
Deep Learning ◽  
Clinical Data ◽  
Chest Radiographs ◽  
Gradient Boosting ◽  
Learning Models ◽  
Icu Admission ◽  
Light Gradient

Background: Patients admitted to the emergency department (ED) with COVID-19 symptoms are routinely required to have chest radiographs and computed tomography (CT) scans. COVID-19 infection has been directly related to development of acute respiratory distress syndrome (ARDS) and severe infections lead to admission to intensive care and can also lead to death. The use of clinical data in machine learning models available at time of admission to ED can be used to assess possible risk of ARDS, need for intensive care unit (ICU) admission as well as risk of mortality. In addition, chest radiographs can be inputted into a deep learning model to further assess these risks. Purpose: This research aimed to develop machine and deep learning models using both structured clinical data and image data from the electronic health record (EHR) to adverse outcomes following ED admission. Materials and Methods: Light Gradient Boosting Machines (LightGBM) was used as the main machine learning algorithm using all clinical data including 42 variables. Compact models were also developed using 15 the most important variables to increase applicability of the models in clinical settings. To predict risk of the aforementioned health outcome events, transfer learning from the CheXNet model was implemented on our data as well. This research utilized clinical data and chest radiographs of 3571 patients 18 years and older admitted to the emergency department between 9th March 2020 and 29th October 2020 at Loyola University Medical Center. Main Findings: Our research results show that we can detect COVID-19 infection (AUC = 0.790 (0.746-0.835)) and predict the risk of developing ARDS (AUC = 0.781 (0.690-0.872), ICU admission (AUC = 0.675 (0.620-0.713)), and mortality (AUC = 0.759 (0.678-0.840)) at moderate accuracy from both chest X-ray images and clinical data. Principal Conclusions: The results can help in clinical decision making, especially when addressing ARDS and mortality, during the assessment of patients admitted to the ED with or without COVID-19 symptoms.

scholarly journals Intensive Treatments in Adolescent Anorexia Nervosa

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1265
Author(s):  
Beate Herpertz-Dahlmann
Keyword(s):  
Health Care ◽  
Anorexia Nervosa ◽  
Intensive Care ◽  
Health Care Systems ◽  
Intensive Treatment ◽  
Stepped Care ◽  
Patient Treatment ◽  
Care Systems ◽  
Treatment Research ◽  
Adolescent Anorexia Nervosa

Approximately one-fifth to one-third of patients with adolescent anorexia nervosa (AN) need intensive care in the course of their illness. This article provides an update and discussion on different levels of intensive care (inpatient treatment (IP), day patient treatment (DP) and home treatment (HoT)) in different health care systems based on recently published literature. Important issues discussed in this article are new recommendations for the refeeding process and the definition of target weight as well as principles of medical stabilization and psychotherapeutic approaches. The pros and cons of longer or shorter hospitalization times are discussed, and the advantages of stepped care and day patient treatment are described. A new promising intensive treatment method involving the patient, their caregivers and the direct home environment is introduced. Parents and caregivers should be included in treatment research to foster collaborative work with the attending clinicians. There is an urgent need to evaluate the mid- to long-term outcomes of various intensive treatment programs to compare their effectiveness and costs across different health care systems. This could help policy makers and other stakeholders, such as public and private insurances, to enhance the quality of eating disorder care.

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